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Spatiotemporal analysis of long-term changes in air temperature is of prime importance for climate change research and the development of effective mitigation and adaptation strategies. Although there is considerable research on air temperature change across the globe, most of it has been on linear trends and time series analysis of nonlinear trends has not received enough attention. Here, we anal
Proper emergency evacuation planning is a key to ensuring the safety and efficiency of resources allocation in disaster events. An efficient evacuation plan can save human lives and avoid other effects of disasters. To develop effective evacuation plans, this study proposed a multi-objective optimization model that assigns individuals to emergency shelters through safe evacuation routes during the
BACKGROUND: Streptococcus pneumoniae remains a major cause of community-acquired pneumonia, meningitis, and other diseases, contributing significantly to high morbidity and mortality worldwide. Although it responds to antibiotics, their use is becoming limited due to the rise in antibiotic resistance, which necessitates the development of new therapeutics. Nanotechnology is used to counteract anti
Biofluids that contain stable calcium phosphate nanoclusters sequestered by phosphopeptides make it possible for soft and hard tissues to co-exist in the same organism with relative ease. The stability diagram of a solution of nanocluster complexes shows how the minimum concentration of phosphopeptide needed for stability increases with pH. In the stable region, amorphous calcium phosphate cannot
BACKGROUND: Tuberculosis (TB) is the leading cause of death for individuals infected with Human immunodeficiency virus (HIV). Conversely, HIV is the most important risk factor in the progression of TB from the latent to the active status. In order to manage this double epidemic situation, an integrated approach that includes HIV management in TB patients was proposed by the World Health Organizati
BackgroundOut-of-hospital cardiac arrest (OHCA) survivors generally report good health-related quality of life, but physical aspects of health seem more affected than other domains. Limitations in physical function after surviving OHCA have received little attention.AimsTo describe physical function 6 months after OHCA and compare it with a group of ST elevation myocardial infarction (STEMI) contr
BACKGROUND: Streptococcus bovis/equinus complex (SBSEC) comprise several species and subspecies and is a common cause of infective endocarditis (IE). S. gallolyticus subsp. gallolyticus (Sg gallolyticus) accounts for a majority of SBSEC IE, but the risk of IE for other subspecies is largely unknown. We aimed to investigate the clinical presentation of bacteraemia, and proportion of patients with I
Differences in morphologies of bacteria and bacteria clusters are known to influence their pathogenicity. However, it is difficult to separate cells and cell clusters based on morphology using standard cell biological methods, making studies of the underlying mechanisms difficult. Here we report a simple label-free method for the continuous separation of clusters of group A streptococci, based on
The European Congenital Heart Surgeons Association (ECHSA) Congenital Database (CD) is the second largest clinical pediatric and congenital cardiac surgical database in the world and the largest in Europe, where various smaller national or regional databases exist. Despite the dramatic increase in interventional cardiology procedures over recent years, only scattered national or regional databases
Immunological control of residual leukemia cells is thought to occur in patients with chronic myeloid leukemia (CML) that maintain treatment-free remission (TFR) following tyrosine kinase inhibitor (TKI) discontinuation. To study this, we analyzed 55 single-cell RNA and T cell receptor (TCR) sequenced samples (scRNA+TCRαβ-seq) from patients with CML (n = 13, N = 25), other cancers (n = 28), and he
Airway basal cells are crucial for regeneration of the human lung airway epithelium, and are thought to be important contributors to Chronic Obstructive Pulmonary Disease (COPD) and other lung disorders. In order to reveal how basal cells contribute to disease, and to discover novel therapeutic targets, these basal cells need to be further characterized. In this study, we optimized a flow cytometr
Min frågeställning är vilken roll Folkhögskolans hade förr och har nu ? Jag har försökt att beskriva dess utveckling, förändring, problem och möjligheter. Jag går tillbaka till år 1844 då den första folkhögskolan startades i Röddinge i Danmark av prästen och folkbildaren Nicolai Frederik Severin Grundtvig. Jag vill försöka ge en bild av folkhögskolans pedagogik, lärare och elever. Jag vill nu ocks
In Sweden, the food and agricultural sector is highly concentrated, especially in the food refinement and retail sectors, with a few major actors holding significant market power. This concentration poses challenges for smaller agri-food companies in Skåne, Sweden. This thesis aims to in depth exploring the challenges smaller agri-food companies face today. The thesis employs a case study approach
The situation for the environment is in many ways dire. However, amidst all the negative environmental developments it is easy to neglect the successes that have actually happened. With the aim of better understanding what factors facilitated such a success this thesis analyses one such case, namely emissions of dioxins and chlorinated waste from the pulp and paper industry in Sweden. Dioxins were
Vår undersökning har följt den svenske rapartisten Einár genom hans karriär. Vi har observerat olika händelser som han har uppmärksammats för, som att han har vunnit pris, att han har blivit kidnappad och rånad, och att han slutligen har blivit skjuten och avled till följd av en skottlossning. Källorna som används är diverse artiklar från SVT Nyheter (som finansieras av public service). I vår anal
The genetic contributions to early onset heart failure (HF) are incompletely understood. Genetic testing in advanced HF patients undergoing heart transplantation (HTx) may yield clinical benefits, but data is limited. We performed deep-coverage whole genome sequencing (WGS) in 102 Swedish HTx recipients. Gene lists were compiled through a systematic literature review. Variants were prioritized for
