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Objective: To identify circulating angiogenic and inflammatory biomarkers with potential in screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc), and in early diagnosis and determination of treatment response in PAH. Method: Plasma samples were taken at the time of PAH diagnosis and at treatment follow-up after a median (interquartile range) of 4 months (3–9.8 months) in
Crisis preparedness planning work can be characterized as complex and challenging being performed in large public organizations requiring communication and cooperation with many people. This paper reports on a bottom-up study investigating the pre-requisites for efficient crisis preparedness work, as well as motivational factors for implementing crisis preparedness decisions, which might be studie
The reasons for the high risk of contralateral breast cancer are not understood, although polygenic mechanisms have been suggested to be involved. The nationwide Swedish Family-Cancer Database was used to examine the interaction of the risks for contralateral and familial cancer. Relative risks were separately determined for contralateral and familial breast cancers, and these were tested for addi
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of over
The recent surge in publications on the history of knowledge may obscure the fact that there are several parallel understandings of what the field is. In this article, I discern five major historiographical directions in contemporary scholarship regarding the history of knowledge. The analytical framework that has so far attracted the most attention is the circulation of knowledge. As productive a
Background Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers. Although several common variants have been associated with breast cancer susceptibility in mutation carriers, none have been associated with ovarian cancer susceptibility. A genome-wide association study recently identified an association between the rare allele of the sing
The cavitation phenomenon has today become a keystone for different areas of science and technology including various industrial processes and medicine. Recently increasing interest and much attention have been paid to study this phenomenon. The last two decades have witnessed the development of numerous devices for different important applications of considerable practical interest, and the rang
An apparatus for static perimetry of the central visual field at 64 points is described. The testing is fully automatic: the test logic is programmed into a mini-computer and the results are plotted as a diagram in polar coordinates. A few cases with small or medium sized visual field defects have been analyzed by conventional methods and by the automatic instrument with satisfying results.
Since 2014 the Swedish government has had a feminist foreign policy. This thesis aims to examine which kind of feminism the policy is built upon. To investigate this a content analysis with a focus on ideas was used. Three different ideal types of feminism were set up from liberal, radical and socialist feminism. The material examined was made up of different official documents from the government
So far, the Standard Model (SM) has been very successful in describing non-gravitational interactions of fundamental particles. However, many of its theoretical and experimental shortcomings remain unresolved. In collider searches, Beyond the Standard Model (BSM) signatures are expected to manifest themselves as localised excesses of events in the invariant mass lineshape of their decay products.
This thesis investigates Stockholm Municipality’s own-price elasticity for organic milk procurement and cross-price elasticity between organic and conventional milk procurement during 2008-2013. Using log-linear specifications with fixed effects, organic milk was found in most specifications to be relatively elastic, while the cross-price elasticity between organic and conventional milk suggests t
Galectins are family of cytosolic proteins that function as both positive and negative modulators of various cell processes. Galectin-3 has an altered expression pattern in pathophysiological processes, such as cancer or chronic inflammation, which makes it an interesting target for pharmaceutical research. The treatment of galectin-3 ill-regulation was shown effective in serious conditions like i
OBJECTIVE-Hemoglobin A(1c) (A1C) has emerged as a recommended diagnostic tool for identifying diabetes and subjects at risk for the disease. This recommendation is based on data in adults showing the relationship between A1C with future development of diabetes and microvascular complications. However, studies in the pediatric population are lacking. RESEARCH DESIGN AND METHODS-We studied a multiet
In order to allow different software applications, in constant evolution, to interact and exchange data, flexible file formats are needed. A file format specification for different types of content has been elaborated to allow communication of data for the software developed within the European Network of Excellence "NANOQUANTA", focusing on first-principles calculations of materials and nanosyste
Popular Abstract in Swedish Adenovirus från människa (Ad) används ofta vid genterapi mot cancer, vaccinutveckling och genöverföring. Modifierade Ad5 och Ad2 virus har framgångsrikt använts som cancercelldödande (onkolytiska) agens i experimentella studier som dock inte kunnat överföras till kliniskt bruk av flera skäl, inklusive bristande spridning av virusinfektionen inom tumörvävnaden. De onkolyHuman adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. The cancer cell killing capacity of oncolytic Ad is
This thesis challenges the treatment of trust income received in a country with no trusts in its legal system in light of freedom of establishment and free movement of capital. Can provisions of a Member State that has decided not to have trusts in its legal system make the transfer of shares or even the establishment of a trust elsewhere less favourable? This question, as the starting point of t
Circular economy has lately gained popularity as a way of dealing with environmental issues. It is a widely defined term and primarily used by companies and states that wish to keep expanding economically while protecting the environment. Through a thematic analysis of the investigation of a circular economy from the Swedish state, the thesis examines which environmental discourses can be read out
