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AXL, a member of the TAM family, is a promising therapeutic target due to its elevated expression in advanced hepatocellular carcinoma (HCC), particularly in association with acquired drug resistance. Previously, RNA interference was used to study its role in cancer, and several phenotypic changes, including attenuated cell proliferation and decreased migration and invasion, have been reported. Th
The impact of different climate scenarios, drought, and water level management on the outflow water quality of peatlands has been investigated. A mesocosm experiment has been conducted within climate control chambers to simulate current (2016–2019 real-time) and future representative concentration pathway (RCP) climate scenarios (RCP 2.6, 4.5 and 8.5). To assess the efficiency of a management stra
Evaluating the structure of soil prior to building construction is valuable in a large variety of geotechnical and civil engineering applications. To built an effective framework for assessing the strength of the stabilised soil, the presented workflow includes a complex approach of simplex lattice design and X-ray diffraction for the analysis of soil structure. Different from the traditional in s
Background: Prediction tools that combine polygenic risk scores with clinical factors provide a new opportunity for improved prediction and prevention of atherosclerotic cardiovascular disease, but the clinical utility of polygenic risk score has remained unclear. Methods: We collected a prospective cohort of 7342 individuals (64% women, mean age 56 years) and estimated their 10-year risk for athe
The late Cambrian Steptoean positive carbon isotope excursion (SPICE) represents a major perturbation to the global carbon cycle and was associated with trilobite extinctions and expansion of anoxic and/or euxinic water masses during episodes of eustatic sea-level change. We present a new Re-Os age together with Os and Nd isotope stratigraphy and major and trace-element data from the Alum Shale Fo
Neurodegenerative disorders are common and heterogeneous in terms of their symptoms and cellular affectation, making their study complicated due to the lack of proper animal models that fully mimic human diseases and the poor availability of post-mortem human brain tissue. Adult human nervous tissue culture offers the possibility to study different aspects of neurological disorders. Molecular, cel
A fundamental problem in radiotherapy is the variation of organ at risk (OAR) volumes. Here we present our initial experience in engaging a large Radiation Oncology (RO) community to agree on national guidelines for OAR delineations. Our project builds on associated standardization initiatives and invites professionals from all radiotherapy departments nationwide. Presently, one guideline (rectum)
We consider the calculations of photoionization spectra and core resonances of open-shell systems using range-separated time-dependent density-functional theory. Specifically, we use the time-dependent range-separated hybrid (TDRSH) scheme, combining a long-range Hartree-Fock exchange potential and kernel with a short-range potential and kernel from a local density-functional approximation, and th
Endosomal entrapment is a key issue for the intracellular delivery of many nano-sized biotherapeutics to their cytosolic or nuclear targets. Photochemical internalisation (PCI) is a novel light-based solution that can be used to trigger the endosomal escape of a range of bioactive agents into the cytosol leading to improved efficacy in pre-clinical and clinical studies. PCI typically depends upon
With the rapid expansion of the waste incineration business both in Europe and globally, there is a growing need for the elemental analysis for fly ash from municipal solid waste incineration. In this work, samples of washed and unwashed ash from municipal solid waste incineration in Sundsvall are evaluated. Qualitative analysis and semi-quantitative analysis are used to compare two elemental anal
3-Bromo-2-(bromomethyl)propyl (dibromoisobutyl or DIB) mono- to tetrasaccharide glycosides were prepared in moderate to high yields by treatment of the corresponding 1-0-acetyl saccharides with 3-bromo-2-(bromo-methyl)propanol (DIBOL) and boron trifluoride etherate. Treatment of the DIB glycosides with alkyl- and ω-methoxycarbonylalkyl thiols gave the corresponding bis-sulfide glycolipids and spac
Type 2 diabetes (T2D) is a polygenic disease and studies to understand the etiology of the disease have required selectively bred animal models with polygenic background. In this review, we present two models; the Goto-Kakizaki (GK) rat and the Oikawa-Nagao Diabetes-Prone (ON-DP) and Diabetes-Resistant (ON-DR) mouse. The GK rat was developed by continuous selective breeding for glucose tolerance f
Introduction: Our objective was determining the optimal combinations of cerebrospinal fluid (CSF) biomarkers for predicting disease progression in Alzheimer's disease (AD) and other neurodegenerative diseases. Methods: We included 1,983 participants from three different cohorts with longitudinal cognitive and clinical data, and baseline CSF levels of Aβ42, Aβ40, phosphorylated tau at threonine-181
The extremely neutron-deficient isotope Au179 has been studied by a combination of in-beam γ-ray and isomeric-decay spectroscopy. For in-beam spectroscopy, the recoil-isomer tagging technique was employed, using the known 3/2-, T1/2=328 ns isomer. A new rotational band, associated with the unfavored signature band of the 1h9/2?2f7/2 proton-intruder configuration, was revealed. A previously unknown
This paper presents an LO phase shifter with frequency tripling for 28-GHz 5G transceivers. The phase shifting and frequency tripling are achieved using an injection-locked oscillator and injection-locked frequency tripler, respectively. A phase detector based on third harmonic mixing is also implemented and is used to detect the applied phase shift, supporting automatic calibration of the phase s
Aims: To develop and validate sex-specific risk prediction models based on easily obtainable clinical data for predicting 5-year risk of type 2 diabetes (T2D) among individuals with impaired fasting glucose (IFG), and generate practical tools for public use. Methods: The data used for model training and internal validation came from a large prospective cohort (N = 18,384). Two independent cohorts
Previous studies have shown that alkali salts influence combustion processes and soot formation, although the effects seem to vary across systems. Moreover, fundamental studies on the effect of potassium and sodium salts on formation of polycyclic aromatic hydrocarbons (PAH), which are precursors in soot formation, are scarce. Here, we report a study in which the effects on PAH formation due to th
This article concerns a field study about the use of non-invasive manual lighting and shading control to save energy in listed buildings. The system was chosen to limit cabling and masonry work. The test room consists of an individual office located in a historical building in Southern Italy. The room was retrofitted with two roller shades (semi-transparent and blackout) and six LED-based pendants
Background: The Catquest-9SF questionnaire is a patient reported outcome measure that quantifies the visual benefits from cataract surgery. The purpose of this study was to translate and adapt the Catquest-9SF questionnaire for France, to assess its psychometric properties via Rasch analysis, and to assess its validity when completed using an electronic notepad. Methods: The Catquest-9SF questionn
Children's participation in economic activities has been documented as an inseparable part of the family support network in childhood studies. Children as an integral part of the parents' world contribute to enhanced social experiences, the continuity of the societal system, and the holistic well-being of the family. In the pro- baby global south children are political, economic, cultural, and soc
