Filtyp
Nutritional epidemiology is an inherently complex and multifaceted research area. Dietary intake is a complex exposure and is challenging to describe and assess, and links between diet, health, and disease are difficult to ascertain. Consequently, adequate reporting is necessary to facilitate comprehension, interpretation, and generalizability of results and conclusions. The STrengthening the Repo
Renovating the European building stock has for almost two decades been a matter of importance. For Sweden, it is important to renovate its multifamily buildings in order to achieve a reduced energy use, but also because renovation is needed due to building materials and services reaching (or having passed) the end of their life span. In order to renovate properly, renovation measures must be imple
Background and Aims: Treatment of synthetic mesh infections has previously often resulted in mesh explantation. Negative pressure wound therapy has been used in these situations with encouraging results. The aims of this study were to evaluate wound healing, mesh preservation, and patient-reported outcome after negative pressure wound therapy of mesh infections. Material and Methods: Medical recor
Background An increased rate of cell death by apoptosis has been implicated in both diabetes and atherosclerosis. Apoptosis can be induced through activation of the death receptors TNF receptor 1 (TNFR-1), TRAIL receptor 2 (TRAILR-2) and Fas. Soluble forms of these receptors are found in plasma. The objective of this study was to determine if soluble death receptors are markers of receptor-activat
The sparse number of high-resolution human membrane protein structures severely restricts our comprehension of molecular physiology and ability to exploit rational drug design. In the search for a standardized, cheap and easily handled human membrane protein production platform, we thoroughly investigated the capacity of S. cerevisiae to deliver high yields of prime quality human AQPs, focusing on
Endosomal entrapment is a key issue for the intracellular delivery of many nano-sized biotherapeutics to their cytosolic or nuclear targets. Photochemical internalisation (PCI) is a novel light-based solution that can be used to trigger the endosomal escape of a range of bioactive agents into the cytosol leading to improved efficacy in pre-clinical and clinical studies. PCI typically depends upon
With the rapid expansion of the waste incineration business both in Europe and globally, there is a growing need for the elemental analysis for fly ash from municipal solid waste incineration. In this work, samples of washed and unwashed ash from municipal solid waste incineration in Sundsvall are evaluated. Qualitative analysis and semi-quantitative analysis are used to compare two elemental anal
Objectives: Long term outcomes following fertility sparing robot-assisted radical trachelectomy (RRT). Methods: A retrospective study of consecutive women selected for RRT between 2007 and 2019 at five referral centres. Generally used selection criteria for fertility-sparing surgery were applied. Oncologic, reproductive and long-term clinical data were analysed. Results: Of the 166 included women,
Background: The aim was to investigate time trends for incidence and long-term net survival in the morphologic subtypes and stages of cervical cancer in Sweden during the period 1960 to 2014. Methods: Women with invasive cervical cancer were identified through the Swedish Cancer Registry. Incidence and net survival were calculated according to morphology, age at diagnosis, and FIGO stage at diagno
Purpose: Image-based analysis of breast tumor growth rate may optimize breast cancer screening and diagnosis by suggesting optimal screening intervals and guide the clinical discussion regarding personalized screening based on tumor aggressiveness. Simulation-based virtual clinical trials (VCTs) can be used to evaluate and optimize medical imaging systems and design clinical trials. This study aim
Background: Comorbidity of bipolar disorder and obsessive-compulsive disorder is common in adolescence. Obsessive-compulsive disorder symptoms may be episodic and secondary to alterations in mood, and display specific features. Management of pediatric bipolar disorder-obsessive-compulsive disorder is challenging, as pharmacotherapy of obsessive-compulsive disorder may induce or exacerbate manic ep
A nasal spray formulation containing an extract of Artemisia abrotanum L. was developed for therapeutic use in patients with allergic rhinitis and other upper airway disorders. The nasal spray preparation used contains a mixture of essential oils (4 mg/ml) and flavonols (2.5 mug/ml), of which some components have been shown to possess antiinflammatory, expectorant, spasmolytic as well as antisepti
In adult soft tissue sarcoma (STS) of the extremities and trunk wall, improved prognostic factors are needed to identify patients at high-risk for metastasis. Various factors are included in the many prognostic systems currently in use and the prognostic value of immunohistochemical (IHC) expression of biological markers is unclear. The tissue-preserving, high throughput tissue microarray (TMA) te
This study aimed to examine how interrogation techniques in the form of alpha and omega strategies, as well as a rapport-based approach by the interviewer, were related to engagement and information disclosure in intelligence interviews. The study was conducted through observation and coding of 66 interviews involving a total of 19 interviewees and 6 interviewers in a training-based and realistica
Small interfering RNAs (siRNAs) are a rapidly growing class of oligonucleotide therapeutics that modulate gene expression by inducing targeted mRNA degradation. siRNAs are potent and their effect is long-lasting, making them promising candidates for chronic neurodegenerative disease. However, siRNAs can elicit both on- and off-target toxicity, and while acute neurotoxicity has been characterized,
The contemporary crisis of public discourse is routinely misdiagnosed as a post-truth disregard for facts. This presentation argues that the deeper pathology is a hyper-eikotic environment: a flood of weaponised plausibilities resulting from the historical schism between demonstrable evidence and persuasive reasoning. To navigate this environment, citizens and critics need more than factchecking;
