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Introduction: Home oxygen therapy is one of the few interventions that can improve survival in patients with chronic obstructive pulmonary disease (COPD) when administered appropriately, although it may cause side effects and be an unnecessary burden for some patients. Areas covered: This narrative review summarizes the current literature on the assessment of hypoxemia, different types of home oxy
Background: COPD management is guided by the respiratory symptom burden, assessed using the modified Medical Research Council (mMRC) scale, the COPD Assessment Test (CAT), or both. Research Question: What are the abilities of mMRC and CAT to detect abnormally high exertional breathlessness on incremental cardiopulmonary cycle exercise testing (CPET) in people with COPD? Study Design and Methods: A
BACKGROUND: Long-term oxygen therapy (LTOT) improves survival in patients with chronic severe resting hypoxaemia, but effects on hospitalisation are unknown. This study evaluated the potential impact of starting LTOT on acute exacerbation and hospital burden in patients with chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD) and pulmonary hypertension (PH).METHODS: Longi
The paper provides an overview and preliminary results from ongoing research with the aim to evolve cross-laminated timber (CLT) into the next generation of Tailored Laminated Timber (TLT). This is done by exploring innovative concepts that optimize the mechanical performance, while simultaneously ensuring adherence to circular economy principles. The current study aims at investigating the potent
BackgroundEndostatin is a promising biomarker for predicting acute kidney injury (AKI) and mortality in the intensive care unit (ICU). We investigated plasma endostatin levels at ICU admission as predictors of new-onset AKI within 48 h after ICU admission, renal replacement therapy (RRT) within 7 days after ICU admission, and 30-day mortality.MethodsA retrospective multicentre study was performed
BACKGROUND: Patients with chronic respiratory failure treated with long-term oxygen therapy (LTOT) often have severe breathlessness, impaired exercise performance, and high but variable mortality that is difficult to predict. We aimed to evaluate breathlessness and exercise performance upon starting LTOT as predictors of overall and short-term mortality.METHODS: This was a longitudinal, population
Utilizing passive floodwater harvesting for artificial recharge and spate irrigation in arid and semiarid areas is an opportunity to use marginal water to improve the livelihood of rural community. In the present study, ground- water modeling to estimate recharge, and field experiments for spate irrigation of barley, were carried out to investigate the performance and potential of water harvesting
Breathlessness is a centrally processed symptom, as evidenced by activation of distinct brain regions such as the insular cortex and amygdala, during the anticipation and/or perception of breathlessness. Inhaled L-menthol or blowing cool air to the face/nose, both selective trigeminal nerve (TGN) stimulants, relieve breathlessness without concurrent improvements in physiological outcomes (e.g., br
Background Exertional breathlessness is commonly assessed using incremental exercise testing (IET), but reference equations for breathlessness responses are lacking. We aimed to develop reference equations for breathlessness intensity during IET. Methods A retrospective, consecutive cohort study of adults undergoing IET was carried out in Sweden. Exclusion criteria included cardiac or respiratory
Objectives: In India, cervical cancer is the most common cancer among women and makes up for up to 29% of all registered cancer in females. Cancer-related pain is one of the major distressing symptoms for all cancer patients. Pain is characterised as somatic or neuropathic, and the total pain experience is often mixed. Conventional opioids are the backbone of analgesic treatment but are most often
Segmentation of grey matter in magnetic resonance images of the spinal cord is an important step in assessing disease state in neurological disorders such as multiple sclerosis. However, manual delineation of spinal cord tissue is time-consuming and susceptible to variability introduced by the rater. We present a novel segmentation method for spinal cord tissue that uses fully convolutional encode
It has recently been argued that in normal decision circumstances no systematic decision method that predicts the likelihood that individuals possess some property can be fair. Either (i) the decision method correctly identifies the relevant property (e.g. recidivism) more often in one subgroup (e.g. black defendants) than another (e.g. white defendants); or (ii) the decision method systematically
This work explores the use of reinforcement learning to design a proactive cloud resource auto-scaler that is able to predict usage across a distributed microservice application. The focus is on serving time-sensitive workloads, e.g., industrial automation, connected XR/VR (eXtended Reality/Virtual Reality), etc., where each job has a deadline and there is some cost associated with missing a deadl
We know that informal networks explain differences in career success. Historical differences in business careers of men and women have frequently been explained with differences in informal networks. We also know that corporations tend to recruit future leaders and professionals from highly ranked business schools, and that important social networks form among the students there. However, it is no
Purpose: This paper aims to comprehensively clarify the research status of thermal transport of supercritical aviation kerosene, with particular interests in the effect of cracking on heat transfer. Design/methodology/approach: A brief review of current research on supercritical aviation kerosene is presented in views of the surrogate model of hydrocarbon fuels, chemical cracking mechanism of hydr
