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Treatment with warfarin in combination with clopidogrel has been shown to reduce the incidence of major bleeding as compared to triple antithrombotic therapy (TT; warfarin, clopidogrel and aspirin). However, there are uncertainties regarding the risk for thrombosis since poor-responsiveness to clopidogrel is common. Ticagrelor is a more potent platelet inhibitor, but data supporting concurrent use

We present a detailed comparison of ectopic ossification (EO) found in tendons of biglycan (Bgn), fibromodulin (Fmod) single and double Bgn/Fmod-deficient (DKO) mice with aging. At 3 months, Fmod KO, Bgn KO and DKO displayed torn cruciate ligaments and EO in their quadriceps tendon, menisci and cruciate and patellar ligaments. The phenotype was the least severe in the Fmod KO, intermediate in the

One of the most important factors governing durability of concrete structures is reinforcement corrosion, and to prevent degradation associated with it, it is desirable to use large concrete covers. However, if the concrete cover is increased, the majority of design methods will predict that the crack widths at the concrete surface increase significantly. This can be contradictory, since the same

Background: Immigrants from the Middle-East are at high risk of developing type 2 diabetes (T2D). The aim of the present survey was to measure, in a single deprived neighbourhood, the prevalence rates of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and T2D in residents originating from Iraq and to compare them to those in residents born in Sweden. An additional aim was to ident

This research aims to fill the knowledge gap with regards to food waste prevention with a specific focus on quick service restaurants (QSRs) – also known as fast food restaurants. Restaurants are in a prime position to reduce food waste produced in the consumptive stages of the food supply chain, and more focus should be placed on how restaurants can help achieve food waste reduction targets. The

Syfte: Uppsatsens syfte är att kvalitativt tydliggöra och förstå skillnader i konsumenters lojalitetsgrad och köpbeteende, kopplat till service, mellan Generation Y och Baby Boomers och på så sätt bidra till service- och generationsforskningen. Metod: En kvalitativ studie med ett hermeneutiskt fenomenologisk förhållningssätt har genomförts. Forskningsansatsen är deduktiv med induktiva inslag. PrPurpose: The aim is to qualitatively distinguish and understand differences in purchase behavior and loyalty, related to service, between Generation Y and Baby Boomers and thus contribute to the service and generational research. Methodology: A qualitative study has been executed with a hermeneutic phenomenological approach. The research approach is deductive while also containing inductive eleme

While localization helps to create websites and mobile apps for specific target markets, not as much attention was devoted to the area of affective virtual service agents. The situation is changing due to advances in affective computing and artificial intelligence. Virtual service agents have the potential to change the way how people interact with information technology by transforming control me

The field of mass evacuation has existed for a long time. Already during the Roman Empire era evacuation problematic was considered. In modern times the field has gained more attention during the last couple of decades, especially for sports grounds and stadiums. Through analysis of some well-known historical crowd disasters and through a literature survey the aim has been to compile the most impo

This single and holistic case study was conducted with a qualitative approach. Our findings show that the change to agile project management is perceived positively by employees. Further the research concludes that the key enablers of cultural change to adopt agile methods are engaging leadership and communication which support the change process. Overall, the study concludes, that agile project m

Avhandlingen ser till hur medvetna exklusiva temahotell är om den fysiska miljön, vi tittar på hotellens grundtanke samt vad de teoretiskt kommunicerar ut till gästen. Vi har valt att avgränsa oss till receptionsområdet och lobbyn där vi diskuterar materiella och immateriella delar av miljön som kan påverka gästens intryck av hotellet. Vi har valt att undersöka hotell i en kategori som vi kallar f

Popular Abstract in Swedish Under sin livstid har Jorden genomlevt upprepade naturliga klimatförändringar. Genom att undersöka dessa klimatförändringar över tid och rum så kan vi öka vår förståelse för underliggande dynamik och mekanismer och därmed bättre förstå klimatsystemet. Två grundläggande förutsättningar för sådana undersökningar är trovärdiga rekonstruktioner av tidigare variationer i styThroughout its history Earth experienced a variety of natural climate changes. By investigating their spatial and temporal evolution we can increase the understanding of the mechanisms and dynamics underlying natural climate change and improve our general comprehension of the climate system. Prerequisites of these investigations are reliable reconstructions of past forcing variations as well as so

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that, if not treated, will progress into blast crisis (BC) of either myeloid or B lymphoid phenotype. The BCR-ABL1 fusion gene, encoding a constitutively active tyrosine kinase, is thought to be sufficient to cause chronic phase (CP) CML, whereas additional genetic lesions are needed for progression into CML BC. To generate a humanize

Identification of determinants of fate choices in hematopoietic stem cells (HSCs) is essential to improve the clinical use of HSCs and to enhance our understanding of the biology of normal and malignant hematopoiesis. Here, we show that high-mobility group AT hook 2 (HMGA2), a nonhistone chromosomal-binding protein, is highly and preferentially expressed in HSCs and in the most immature progenitor

The response of childhood acute lymphoblastic leukemia (ALL) to dexamethasone predicts the long-term remission outcome. To explore the mechanisms of dexamethasone resistance in B cell ALL (B-ALL), we generated dexamethasone-resistant clones by prolonged treatment with dexamethasone. Using RNA-sequencing and high-throughput screening, we found that dexamethasone-resistant cells are dependent on rec

The distinct lineage potential is a key feature of hematopoietic stem cell (HSC) heterogeneity, but a subset of HSCs specialized for a single lymphoid compartment has not been identified. Here we report that HSCs expressing junctional adhesion molecule 2 (Jam2) at a higher level (Jam2high HSCs) have a greater T cell reconstitution capacity. Jam2high HSCs are metabolically dormant but preferentiall

INTRODUCTION: More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associatio