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The discovery of novel protein biomarkers in melanoma is crucial. Our introduction of formalin-fixed paraffin-embedded (FFPE) tumor protocol provides new opportunities to understand the progression of melanoma and open the possibility to screen thousands of FFPE samples deposited in tumor biobanks and available at hospital pathology departments. In our retrospective biobank pilot study, 90 FFPE sa

BACKGROUND: A gel-free proteomic approach was utilized to perform in-depth tissue protein profiling of lung adenocarcinoma (ADC) and normal lung tissues from early and advanced stages of the disease. The long-term goal of this study is to generate a large-scale, label-free proteomics dataset from histologically well-classified lung ADC that can be used to increase further our understanding of dise

It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal i

Background: Endotoxin may cause inflammation and increased intestinal permeability in infants with immature immune systems and gut microbiota. This study analysed the presence of endotoxin together with other potentially hazardous agents in commercial infant cereals. Methods: Four porridges and six milk cereal drinks bought in Sweden were analysed for the presence of endotoxins using Endosafe MCS.

Organisms in the wild are faced with multiple threats and a common response is a change in behaviour. To disentangle responses to several threats, we exposed two differently sized species of the freshwater invertebrate Daphnia to solar ultraviolet radiation (UVR) and predation from either moving pelagic or benthic ambush predators. Using an advanced nanotechnology-based method, we tracked the thre

Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR) expression. Targeting proteins that are expressed as a down-stream effect of AR activity is a promising rationale for management of this disease. The hum

Background: Prostate-specific antigen (PSA) screening reduces prostate cancer deaths but leads to harm from overdiagnosis and overtreatment. Objective: To determine the long-term risk of prostate cancer mortality using kallikrein blood markers measured at baseline in a large population of healthy men to identify men with low risk for prostate cancer death. Design, setting, participants: Study base

The tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 expression could predict platinum response in primary ovarian carcinoma (OC). Claudin-4 expression was evaluated by immunohistochemistry in a tissue microarray of 140 OCs. Multivariable Cox-regression mo

OBJECTIVE: To study how the incidence of cancer is related to diabetes, obesity or abnormal blood lipids. METHODS: Diagnosis of diabetes, obesity or abnormal blood lipids was studied 0-10 years prior to the diagnosis of cancer in 19,756 cases of cancer and in 147,324 controls matched regarding age, sex and domicile. RESULTS: Diabetes was significantly more common prior to diagnosis in patients w

PURPOSE: Whether childhood adrenocortical tumors (ACTs), choroid plexus tumors (CPTs), and rhabdomyosarcoma (RMS) are early manifestation of Li-Fraumeni syndrome (LFS) is uncertain. In this study, we evaluated the frequency of germline TP53 mutations and family history in a population-based series of patients. PATIENTS AND METHODS: We identified children (≤18 years) diagnosed between 1958 and

PURPOSE: For primary melanomas, tumor thickness, mitotic rate and ulceration are well-laid cornerstones of prognostication. However, a molecular exposition of melanoma aggressiveness is critically missing. We recently uncovered a four-class structure in metastatic melanoma that predicts outcome and informs biology. This raises the possibility that a molecular structure exists even in the early st

Phenotypic characteristics were examined in melanoma-prone southern Swedish CDKN2A (p16-113insArg/p14ARF-128insSer) mutation families, in relation to the CDKN2A genotype, nevi, clinically atypical nevi (CAN) and melanoma. Individuals from eight melanoma-prone families, with index patients carrying the CDKN2A mutation, were offered skin examinations and genotyping (CDKN2A and MC1R). Ninety-three in

Aim: The overall aim of was to investigate the impact of self-reportedallergic disease on physical activity (PA) and health-related quality oflife (HRQoL) among adolescents.Methods: A cross-sectional analysis of 1 181 adolescents aged 13-14years (251 with current allergic disease), participating in the baselineinvestigation of the Southern Sweden allergy cohort, including a surveywith questions on

Utredningsrapport - Sammanslagning av geologi, INES och CEC Page 1 of 40 Reg. No. STYR 2022/1317 Date 2022-11-14 Postal address Kansli N, Box 118, 221 00 Lund Visiting address Astronomy building, Sölvegatan 27 Telephone 046-222 7182, (switch) 046-222 00 00 E-mail: Tobias.Nilsson@science.lu.se Investigation of how research in the Department of Geology, the Department of Physical Geography and Ecosy

https://www.science.lu.se/internal/sites/science.lu.se.internal/files/2023-01/external-investigation-joint-department.pdf - 2026-05-24

EPIHEALTH COMMUNICATIONS STRATEGY LUND UNIVERSITY | FACULTY OF MEDICINE | DEPARTMENT OF CLINICAL SCIENCES, MALMÖ NO. 1 | 2021 Epidemiology for Health How do genes interact with the environment for risk of disease? What links dietary intake, gut microbiota and organ function? How does early life factors influence adult health? Why do patients with the same disease have different prognosis? 2 TABLE

https://www.epihealth.lu.se/en/sites/epihealth.lu.se.en/files/2021-06/Communications%20Strategy_June%202021.pdf - 2026-05-24

EPIHEALTH COMMUNICATIONS STRATEGY LUND UNIVERSITY | FACULTY OF MEDICINE | DEPARTMENT OF CLINICAL SCIENCES, MALMÖ NO. 1 | 2021 Epidemiology for Health How do genes interact with the environment for risk of disease? What links dietary intake, gut microbiota and organ function? How does early life factors influence adult health? Why do patients with the same disease have different prognosis? 2 TABLE

https://www.epihealth.lu.se/en/sites/epihealth.lu.se.en/files/2021-09/EpiHealth_Communications%20Strategy_June%202021.pdf - 2026-05-24

Bilaga rektorsbeslut Dnr: V 2023/303 2023-02-16 1 (22) Redovisning av miljöledningsarbetet 2022 Lunds universitet Enligt förordning (2009:907) om miljöledning i statliga myndigheter Del 1 Miljöledningssystemet Basfakta Antal årsarbetskrafter: 7 485 Antal kvadratmeter lokalyta: 425 892 1. Är myndigheten miljöcertifierad? Nej. 2. Hur lyder myndighetens miljöpolicy? Lunds universitets policy för håll

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2023-03/lunds-universitets-miljoredovisning-2022-ej-tillg.pdf - 2026-05-24

DB22en08_proof.pdf Kendra Vehik,1 David Boulware,1 Michael Killian,2 Marian Rewers,3 Richard McIndoe,4 Jorma Toppari,5 Åke Lernmark,6 Beena Akolkar,7 Anette-G Ziegler,8 Henry Rodriguez,9 Desmond A. Schatz,10 Jeffrey P. Krischer,1 and William Hagopian,2 for the TrialNet Study Group and TEDDY Study Group* Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well

https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-04/146%20Vehik_Diab%20Care_2022_3.pdf - 2026-05-24

Lund University aspires to be at the very forefront of both research and education for sustainability, and in 2024 Lund University was ranked 8th in the world in the QS Sustainability Rankings. As a step further in this direction, the university has decided to allocate up to SEK 100 million to a university-wide excellence initiative for postdocs and PhD students focusing on Agenda 2030 and sustain

https://www.sustainability.lu.se/research/excellence-programme-sustainable-development - 2026-05-23