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Streptococcal pharyngitis is among the most common bacterial infections, but the molecular mechanisms involved remain poorly understood. Here we investigate the interactions among three major players in streptococcal pharyngitis: streptococci, plasma, and saliva. We find that saliva activates the plasma coagulation system through both the extrinsic and the intrinsic pathways, entrapping the bacter
We discuss finite volume effects and partial quenching for Chiral Perturbation Theory in the mesonic sector. The effects are computed in terms of analytical expressions for masses, decay constants and vacuum expectation values (VEVs) to two-loop order. Numerical examples are presented for a number of interesting and relevant cases. All numerical programs are publically available, the prospects of
SynopsisVarious protolytic species of thiols RSH (thioglycolic acid, l-cysteine, dl-penicillamine, and glutathione) in rapid equilibria with each other reduce trans-[Pt(CN)4Cl2]2- in parallel, halide-bridged electron transfer reactions. A linear Brønsted correlation between the reactivity of the thiolate anions RS- and their basicity is observed. The mechanism derived might be used as a model for
Blodet bär med sig syre och näringsämnen som är vitala för vävnadens överlevnad, och därför är karakterisering av hjärnans blodförsörjning av stor betydelse. Blodflödet i kapillärerna kallas för perfusion. Vid MRI-baserad perfusionsmätning i hjärnan utnyttjas ofta signalförändringar orsakade av ett spårämne i blodet. Spårämnet kan antingen skapas internt genom märkning av det arteriella inflödet aDiffusion and perfusion MRI are valuable methods for investigating the microstructure and viability of tissue. One pure diffusion study was included in this thesis, with the purpose of studying microstructure and carrying out size estimations with the q-space diffusion imaging method. This is a method that has predominantly been explored with NMR spectrometers. In our study, a biological phantom c
Open access has established itself as an issue that researchers, universities, and various infrastructure providers, such as libraries and academic publishers, have to relate to. Commonly policies requiring open access are framed as expanding access to information and hence as being part of a democratization of society and knowledge production processes. However, there are also other aspects that
Procedural sedation and analgesia (PSA) has become a widespread practice given the increasing demand to relieve anxiety, discomfort and pain during invasive diagnostic and therapeutic procedures. The role of, and credentialing required by, anaesthesiologists and practitioners performing PSA has been debated for years in different guidelines. For this reason, the European Society of Anaesthesiology
AIMS AND OBJECTIVES: To investigate the cancer rehabilitation experiences of working-age cancer survivors.BACKGROUND: Cancer survivors have extremely complex needs, spanning physical, vocational, and sexual domains. Although cancer rehabilitation services have been found to eliminate or reduce these strains, these services are often underutilized.DESIGN: A cross-sectional study design was employed
BackgroundThe majority of people with dementia prefer to live independently and safely in their own home cared for by their family members. Much effort has been invested in the development of technology, such as sensor‐based networks. Many challenges remain, in particular gaining more knowledge about their experiences and perceived benefits. This study aimed to explore experiences, needs and benef
The main objective of the study was to investigate the thermal performance of five (open and closed) bicycle helmets for convective and evaporative heat transfer using a nine-zone thermal manikin. The shape of the thermal manikin was obtained by averaging the 3D-point coordinates of the head over a sample of 85 head scans of human subjects, obtained through magnetic resonance imaging (MRI) and 3D-
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and asthma are common diseases with a heterogeneous distribution worldwide. Here, we present methods and disease and risk estimates for COPD and asthma from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2015 study. The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (
Climate change is expected to severely affect cropping systems and food production in many parts of the world unless local adaptation can ameliorate these impacts. Ensembles of crop simulation models can be useful tools for assessing if proposed adaptation options are capable of achieving target yields, whilst also quantifying the share of uncertainty in the simulated crop impact resulting from th
The standard therapy for patients with haemophilia is prophylactic treatment with replacement factor VIII (FVIII) or factor IX (FIX). Patients who develop inhibitors against FVIII/FIX face an increased risk of bleeding, and the likelihood of early development of progressive arthropathy, alongside higher treatment-related costs. Bypassing agents can be used to prevent and control bleeding, as well
In this paper we derive the finite-sample distribution of the estimated weights of the tangency portfolio when both the population and the sample covariance matrices are singular. These results are used in the derivation of a statistical test on the weights of the tangency portfolio where the distribution of the test statistic is obtained under both the null and alternative hypotheses. Moreover, w
Anxiety and stress-related disorders are highly prevalent and impede participation in life activities. Occupational therapists work extensively with people diagnosed with these disorders but the effectiveness of their interventions is unclear. A systematic search strategy identified 19 papers describing 13 studies. Studies varied in methodology, intervention type, and theory base. The results show
