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The discovery of novel protein biomarkers in melanoma is crucial. Our introduction of formalin-fixed paraffin-embedded (FFPE) tumor protocol provides new opportunities to understand the progression of melanoma and open the possibility to screen thousands of FFPE samples deposited in tumor biobanks and available at hospital pathology departments. In our retrospective biobank pilot study, 90 FFPE sa

BACKGROUND: A gel-free proteomic approach was utilized to perform in-depth tissue protein profiling of lung adenocarcinoma (ADC) and normal lung tissues from early and advanced stages of the disease. The long-term goal of this study is to generate a large-scale, label-free proteomics dataset from histologically well-classified lung ADC that can be used to increase further our understanding of dise

The disruption of microtubule dynamics serves as a pivotal strategy for eliminating tumor cells, despite its accompanying toxicities affecting non-tumor cells. This study investigates the potential of selectively targeting γ-tubulin1 (TUBG1) as a therapeutic strategy in cancer treatment. By elucidating the TUBG1-E2F1-retinoblastoma protein (RB1) network, we introduce a novel compound, 4-(6-((3-Met

Alexander disease (AxD) is a rare and severe neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, previous studies suggest that mutant GFAP influences many cellular processes, including cytoskeleton stability, mechanosensing, metabolism, and proteasome function. While most studies have primarily focused on GFAP

The COVID-19 pandemic caught the world largely unprepared, including scientific and policy communities. On April 10-13, 2022, researchers across academia, industry, government, and nonprofit organizations met at the Keystone symposium "Lessons from the Pandemic: Responding to Emerging Zoonotic Viral Diseases" to discuss the successes and challenges of the COVID-19 pandemic and what lessons can be

Oppositely charged polymer-surfactant systems are expected to interact with formation of coacervate complexes near composition of charge-neutrality. Such behaviour is widely used in formulated products (e.g. household and personal care), where the co-deposition of coacervates and active ingredients on various surfaces is triggered by dilution. A transition towards the use of more sustainable ingre

This study explores the coating of photocatalytic nanoparticles with antimicrobial peptides (AMPs) for boosted antimicrobial effects, and how such effects depend on AMP properties. For this, TiO2 nanoparticles are coated with the AMP KYE21 or its hydrophobically enhanced variant WWWKYE21. Mirroring effects of free peptides, coated nanoparticles displayed higher binding and UV-induced degradation f

Aim: The overall aim of was to investigate the impact of self-reportedallergic disease on physical activity (PA) and health-related quality oflife (HRQoL) among adolescents.Methods: A cross-sectional analysis of 1 181 adolescents aged 13-14years (251 with current allergic disease), participating in the baselineinvestigation of the Southern Sweden allergy cohort, including a surveywith questions on

Popular Abstract in Swedish Projektioner om framtida klimat i Arktis och subarktis tyder på att drastiska förändrinar väntar regionen under det närmaste århundradet. Inte bara temperaturen spås öka utan även nederbörd, och då framför allt nederbörden under vinterhalvåret. Dessa förändringar kommer sannolikt att ha stor inverkan på miljön i Arktis och subarktis, och stora forksningsansträngningar hClimate projections indicate that Arctic and sub-Arctic regions are facing a significant change in climate during the 21st century. With warmer temperatures precipitation is also expected to increase, and in particular winter precipitation. These changes are likely to have large impacts on the Arctic and subarctic environment, and extensive research has focused on ecosystem-climate interactions in

Charges and their contribution to protein-protein interactions are essential for the key structural and dynamic properties of monoclonal antibody (mAb) solutions. In fact, they influence the apparent molecular weight, the static structure factor, the collective diffusion coefficient, or the relative viscosity, and their concentration dependence. Further, charges play an important role in the collo

Background: While neighborhood deprivation is a well-known predictor of obesity, the mechanisms behind this association are unclear and these are important to clarify before designing interventions focusing on modifiable neighborhood environmental factors in order to reduce obesity risk. Objectives: This study examined the longitudinal association between availability of fast-food outlets and phys

Denna avhandling undersöker de politiska orsakerna till reformer av subventioner av fossila bränslen i OECD-länderna mellan 2009 och 2023. Trots att subventioner för fossila bränslen är allmänt erkända som ekonomiskt ineffektiva och miljöskadliga, är de fortfarande djupt rotade, där OECD-länderna tillsammans upprätthåller ett årligt stöd på cirka 100 miljarder US-dollar. Avhandlingen behandlar fråThis dissertation investigates the political determinants of fossil fuel subsidy reform in OECD countries between 2009 and 2023. Despite widespread recognition of their economic inefficiency and environmental harm, fossil fuel subsidies remain entrenched, with OECD countries collectively sustaining around USD 100 billion in annual support. The research addresses why some governments successfully r

OBJECTIVE: To study how the incidence of cancer is related to diabetes, obesity or abnormal blood lipids. METHODS: Diagnosis of diabetes, obesity or abnormal blood lipids was studied 0-10 years prior to the diagnosis of cancer in 19,756 cases of cancer and in 147,324 controls matched regarding age, sex and domicile. RESULTS: Diabetes was significantly more common prior to diagnosis in patients w

PURPOSE: Whether childhood adrenocortical tumors (ACTs), choroid plexus tumors (CPTs), and rhabdomyosarcoma (RMS) are early manifestation of Li-Fraumeni syndrome (LFS) is uncertain. In this study, we evaluated the frequency of germline TP53 mutations and family history in a population-based series of patients. PATIENTS AND METHODS: We identified children (≤18 years) diagnosed between 1958 and

The growing complexity of urban energy systems, climate uncertainties, and geopolitical disruptions highlight the need for energy flexibility and smart management. Recent developments in smart buildings enable real-time adaptability and collective energy behavior through the deployment of Reinforcement Learning (RL), which optimizes energy use, integrates distributed resources, and enhances demand

Carbon Black (CB), graphene, and nanodiamonds represent three classes of manufactured carbonaceous nanoparticles consisting almost exclusively of insoluble material. Particle-related Reactive Oxygen Species (ROS) have been linked to in vivo and in vitro toxicity and determining particle ROS activity is an efficient way of estimating nanomaterial toxicity and assist in the safe-by-design developmen

Aluminum (Al), as a carbon-free energy source, features favorable characteristics regarding its production, transportation, utilization, and recyclability. The combustion of single Al particles mainly occurs as a vapor-phase diffusion flame, wherein the gas-phase combustion kinetics plays an important role. However, the understanding of the kinetics is still limited and rate constants for the same

Multi-wavelength thermo-optical analysis (MW-TOA) and Raman spectroscopy are commonly used methods to study soot sampled on filters, in terms of carbon content, nanostructure, and absorption properties. In this work, these techniques were combined to study how these characteristic properties of soot change in premixed flames, 1) at various flame heights during soot maturation and 2) as a result of

2012-2014 2007-2010 2006-2007 2005 2011 2010 2016 2015 2014 2013 2012 2011 2010 Malmø Art Academy, Post graduate Diploma MFA Fine Art, Sweden Goldsmiths, University of London, Honours BA Fine Art Practice, United Kingdom Central Saint Martins, University of London, Performance design, United Kingdom Bjørn Ignatius Øchenholts Billedkunstskole, Copenhagen, Denmark Film Editor at DFI / The Danish Fil

https://www.khm.lu.se/sites/khm.lu.se/files/2014cv_helenenymann.pdf - 2026-05-22

Popular Abstract in Swedish Mycorrhiza är en samexistens mellan trädrötter och svampar i jorden. Svampen förser trädet med mineralnäringsämnen från jorden och i utbyte får den socker från trädet. Sockret produceras via fotosyntesen och transporteras sedan ner till rötterna där de förs vidare till svamphyferna. Det har visats att mycorrhizasvampar kan ta upp näringsämnen direkt från mineraler i jEctomycorrhiza are a symbiosis between trees and soil inhabiting fungi. The fungal hyphae ensheath the fine roots creating a mantle and grow in between root cells to create the Hartig net, where the exchange of carbon and mineral nutrients occurs. The ectomycorrhizal fungus is dependent on the host tree to receive the carbon it needs to grow. Trees with different nutrient deficiencies differ in t