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Hematopoietic cells emerge from hemogenic endothelium in the developing embryo. Mechanisms behind human hematopoietic stem and progenitor cell development remain unclear. Using a human pluripotent stem cell differentiation model, we report that cyclic AMP (cAMP) induction dramatically increases HSC-like cell frequencies. We show that hematopoietic cell generation requires cAMP signaling through th

To make glomerular filtration rate (GFR) estimating equations applicable across populations with different creatinine generation by using rescaled serum creatinine (sCr/Q) where sCr represents the individual creatinine level and Q the average creatinine value in healthy persons of the same population. GFR measurements (mGFR, plasma clearance of 51Cr-EDTA) were conducted in 964 adult Black European

Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all

Background ODM-201, a new-generation androgen receptor inhibitor, has shown clinical efficacy in prostate cancer (PCa). Quantitative methods are needed to accurately assess changes in bone as a measurement of treatment response. The Bone Scan Index (BSI) reflects the percentage of skeletal mass a given tumour affects. Objective To evaluate the predictive value of the BSI in metastatic castration-r

Background: In a previous population-based study on 3369 European men with self-reported prostate cancer (PCa), it was shown that androgen receptor (AR) haplotype designated H2 was associated with high levels of serum PSA (prostate-specific antigen) concentration, and, at the same time, with low risk for PCa. The aim of this study was to replicate this finding in other cohorts, with registry-based

Hypoxia and acidosis are inherent stress factors of the tumor microenvironment and have been linked to increased tumor aggressiveness and treatment resistance. Molecules involved in the adaptive mechanisms that drive stress-induced disease progression constitute interesting candidates of therapeutic intervention. Here, we provide evidence of a novel role of heparan sulfate proteoglycans (HSPG) in

BACKGROUND: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) is a group of autoimmune diseases, characterized by small vessel inflammation. Phagocytes such as neutrophils and monocytes are the main effector cells found around the inflamed vessel wall. Therefore, we wanted to investigate aspects of function and activation of these cells in patients with AAV.METHODS: Flow cytomet

Professor Contact details Email: dan [dot] hammarlund [at] mgeo [dot] lu [dot] seOrganisation Department of Earth and Environmental Sciences (MGeo) Visiting address: Sölvegatan 12, Service point: 16 WebpageDan Hammarlunds profile in Lund University research portalOther affiliations Professor Department of Geology Member of Strategic Research Area BECC: Biodiversity and Ecosystem services in a Chan

https://www.geology.lu.se/dan-hammarlund - 2026-05-14

Litteraturlista ARAB17 Språk- och litteraturcentrum Arabiska LITTERATURLISTA ARAB17 (Arabiska, Grundkurs 1, 15 hp) Fastställd av styrelsen för sektion 5 2018-05-31 ----------------------------------------------------------------------------------------------------------------- Delkurs 1, Grundläggande arabisk grammatik III (7,5hp) Abu-Chacra, Faruk, Arabiska: grammatik med övningar, 1. uppl., Stud

https://www.sol.lu.se/media/utbildning/dokument/kurser/ARAB17/20192/Litteraturlista_ARAB17.pdf - 2026-05-14

Dimensionering av glasbalkar LTH Ingenjörshögskolan vid Campus Helsingborg Institution för byggvetenskaper Examensarbete: Lukasz Jaskiewicz Per Nyström  Copyright Lukasz Jaskiewicz, Per Nyström LTH Ingenjörshögskolan vid Campus Helsingborg Lunds universitet Box 882 251 08 Helsingborg LTH School of Engineering Lund University Box 882 SE-251 08 Helsingborg Sweden Tryckt i Sverige Media-Tryc

https://www.byggmek.lth.se/fileadmin/byggnadskonstruktion/publications/THID/THID5285.pdf - 2026-05-14

This study examined the relationship between adult attachment dimensions and life satisfaction among expatriates residing in European countries, with a particular focus on the challenges of social isolation and cultural adaptation. It hypothesized that expatriates with secure attachment styles were more likely to report higher levels of life satisfaction compared to those with avoidant or anxious

Using several melanoma proteomics data sets we created a single analysis platform that enables the discovery, knowledge build, and validation of diagnostic, predictive, and prognostic biomarkers at the protein level. Quantitative mass-spectrometry-based proteomic data was obtained from five independent cohorts, including 489 tissue samples from 394 patients with accompanying clinical metadata. We

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of over

Background Nocturia is one of the most prevalent and bothersome lower urinary tract symptoms (LUTS) in men, leading to increased morbidity and mortality and a considerable economic burden on healthcare systems. Understanding its natural history, effect of pharmacotherapy, and predictors of failure of pharmacotherapy would allow optimised patient management. Objective To evaluate the prevalence an

Deposition of aerosol nanoparticles using an electrostatic precipitator is widely used in the aerosol community. Despite this, basic knowledge regarding what governs the deposition has been missing. This concerns the prediction of the size of the particle collection zone, but also, perhaps more importantly, prediction of the nanoparticle concentration distribution on the substrate, both of which a

Statement of Purpose: Lung cancer is the leading cause of cancer-related deaths and efficient therapies remain elusive. One emerging approach is to use nanoparticles (NPs) that are designed to specifically target malignant cells (1). Such targeting increases on-site drug doses and reduces systemic side effects. A common target in lung tumors is epidermal growth factor receptor (EGFR). Here, we ex

Protein biomarkers for epithelial ovarian cancer are critical for the early detection of the cancer to improve patient prognosis and for the clinical management of the disease to monitor treatment response and to detect recurrences. Unfortunately, the discovery of protein biomarkers is hampered by the limited availability of reliable and sensitive assays needed for the reproducible quantification

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. Activation of FLT3 leads to its autophosphorylation and initiation of several signal transduction cascades. Signaling is initiated by the recruitment of sig