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Complement is a key arm of the innate immune defenses against the pathogenic neisseriae. We previously identified lipooligosaccharide on Neisseria meningitidis as an acceptor for complement C4b. Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization and killing. In this study we demonstrate that N. g
A stratified viscoelastic medium in the time domain is characterised by two creep compliances that are functions of time and depth, and a density that is a function of depth. In this paper the direct scattering problem of a plane horizontal shear wave obliquely incident on a stratified viscoelastic medium is treated in detail. A general discussion of the corresponding inverse problem is given. A s
Several new oral antidiabetic agents, known as 'gliptins' or 'enzyme dipeptidyl peptidase-IV (DPP-4) inhibitors', have been developed for the treatment of type 2 diabetes and a key clinical use of the gliptins is in combination with metformin. There are important differences in the kinetics of the interaction of different gliptins with the catalytic site of DPP-4, which may lead to varying pharmac
Accumulating evidence implicates a role for altered metal homeostasis in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). However, few investigations have addressed this issue in dementia with Lewy bodies (DLB). The aim of the present study was to investigate metal concentrations in cerebrospinal fluid (CSF) and plasma from patients with DLB and other neurodegenera
In a recent paper, Cetinkaya and Lee (2000) model integrated inventory control and shipment scheduling in connection with vendor-managed inventory (VMI). The model is optimized by an approximate technique. This note provides a simple procedure for exact optimization, and illustrates that the errors when using the suggested approximate technique may be very large for certain types of problems. We a
Abstract BACKGROUND: Family history has been suggested as a risk factor for varicose veins, but recall bias may inflate the familial risks. The aim of this nationwide study was to determine familial risks for hospital treatment for varicose veins. METHODS: Data from the Swedish Multi-Generation Register of people aged 0-76 years were linked to Hospital Discharge Register data for 1964-2008. Stand
Dysfunction of the gastrointestinal tract has now been recognized to affect all stages of Parkinson's disease (PD). The consequences lead to problems with absorption of oral medication, erratic treatment response, as well as silent aspiration, which is one of the key risk factors in developing pneumonia. The issue is further complicated by other gut abnormalities, such as small intestinal bacteria
Emboldened by the aesthetic,- emotional-, and corporeal turns in the study of world politics, International Relations (IR) scholars are increasingly paying attention to the political dimension of affects and emotions. Yet while, so far, affect and emotions have been studied as (micro-political) forces that circulate between bodies in the context of the everyday, little attention has been given to
Living in a complex and dynamically changing environment requires accurate and timely behavioural responses that allow for adapting to such changes. Well-developed perceptual systems provide a continuous flow of abundant and up-to-date information on the changes in the environment, and, thereby, allow for tailoring behavioural responses accordingly. However, issuing any behavioral response would n
Objective: To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular osteoarthritis (OA) that are derived from expert consensus and based on objective review of high-quality meta-analytic data. Methods: We sought evidence for 60 unique interventions. A sy
We detail here the convergence properties of a new model-independent imaging method, the Lévy expansion, that seems to play an important role in the analysis of the differential cross section of elastic hadron-hadron scattering. We demonstrate, how our earlier results concerning the Odderon effects in the differential cross-section of elastic proton-proton and proton-antiproton scattering as well
PURPOSE: Analyze the goals for treatment and attained goals for spinal orthoses in children with cerebral palsy (CP), and describe the use of spinal orthoses in relation to age, sex, gross motor function, and scoliosis. METHODS: Cross-sectional data for all children born between 2000 and 2014 and registered in the Swedish CP registry were analyzed in relation to age, sex, Gross Motor Function Clas
This study examines the geopolitical role of 14 metals and metalloids needed for renewable energy technologies. The analysis focuses on three factors with potential geopolitical importance: the geographic concentration of resources, potential revenues of resources rich countries and the size of total global markets. The geographic concentration of most of the fourteen studied metals and metalloids
This paper attempts to assemble a conceptual framework for understanding to what extent an energy technology is simply a way of putting nature to work, and to what extent it is a way of putting other segments of global society to work. The turn to fossil energy reversed the relation between energy and space, as fossil fuels henceforth propelled new transport technologies that provided access to in
In this contribution a practical and rational decision-making approach is presented to be applied for common bridges typically managed by public authorities. The authors have developed a model with the intention to be applicable for practical cases for common bridges in the daily work of bride operators responsible for a large number of assets, yet still maintain the principles of more generic fra
As urban systems continue to grow worldwide, urban peripheries increase in number and typologies, which makes their planning a challenge for sustainable development. The aim of this article is to explore approaches and challenges related to the application of sustainable planning to urban peripheries. We reviewed the content of 102 papers related to sustainable planning in urban peripheries by app
