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The morphogenetic protein DivIVA exhibits diverse functions across bacterial phyla. In Bacillota, DivIVA is primarily involved in cell division, whereas in Actinomycetota, it plays a central role in coordinating polar growth. Due to its essentiality in Actinomycetota, gaining insight into its structural functions is challenging. We studied truncated DivIVA proteins using a unique divIVA deletion m

Dexterous in-hand manipulation offers significant potential to enhance robotic manipulator capabilities. This paper presents a sensori-motor architecture for in-hand slip-aware control, being embodied in a sensorized gripper. The gripper in our architecture features rapid closed-loop, low-level force control and is equipped with sensors capable of independently measuring contact forces and sliding

Large amounts of dendrochronological data sets exported from the SEAD databasehave in this study been used to analyze timber trade and provenance from thethree Scandinavian towns of Copenhagen, Stockholm and Nya Lödöse/Gothenburgduring the medieval and early modern era. In total, 964 dendrochronologicalsamples with a dating and provenance description were compiled in this studyand compared with wrLarge amounts of dendrochronological data sets exported from the SEAD database have in this study been used to analyze timber trade and provenance from the three Scandinavian towns of Copenhagen, Stockholm and Nya Lödöse/Gothenburg during the medieval and early modern era. In total, 964 dendrochronological samples with a dating and provenance description were compiled in this study and compared wi

Cellular senescence, a phenomenon characterized by the accumulation of dysfunctional, metabolically active cells, is increasingly recognized to be a key player in aging-related metabolic disorders. It is accelerated by hyperglycemia through various molecular pathways, positioning it as a critical mechanism in the pathophysiology of type 2 diabetes mellitus (T2D) and a potential therapeutic target.

Single-master multi-slave (SMMS) teleoperation systems can perform multiple tasks remotely in a shorter time, cover large-scale areas, and adapt more easily to single-point failures, thereby effectively encompassing a broader range ofapplications. As the number of slave manipulators sharing a communicationnetwork increases, the limitation of communication bandwidth becomes critical. To alleviate b

The unification of quantum mechanics and general relativity has long been elusive. Only recently have empirical predictions of various possible theories of quantum gravity been put to test, where a clear signal of quantum properties of gravity is still missing. The dawn of multi-messenger high-energy astrophysics has been tremendously beneficial, as it allows us to study particles with much higher

Climate warming is expected to influence the prevalence of vector-transmitted parasites. Understanding the extent to which this is ongoing, or has already occurred, requires empirical data from populations monitored over long periods of time, but these studies are sparse. Further, vector-disease research involving human health is often influenced by disease control efforts that supersede natural t

Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At national funding level, endocrine societies report limited or little attention of national res

Mantle cell lymphoma (MCL) is a relatively rare B-cell lymphoma subtype, with a higher incidence among males and a median age of 70 years at diagnosis. MCL is characterized by clinically diverse behavior, from indolent disease to extremely aggressive, related to the presence of biological risk factors such as proliferation rate and TP53 mutations. Most often, patients present with disseminated dis

Nepal has made major progress in expanding its national electricity grid, creating the potential for a double transition as increased access to electricity benefits the energy-poor while setting the infrastructural ground for a transition to renewable energy sources. However, despite increased access, many households in Nepalcontinue to rely on traditional and transition fuels such as firewood and

Ever-increasing global water shortages necessitate more advanced and cost-effective water purification methods. Herein, a novel slow filtration system using natural raw zeolite is proposed as an alternative to traditional quartz sand as a filter medium. The system demonstrates excellent performance in reducing turbidity and removing methylene blue (MB). The natural zeolite-based filtration system

A central challenge in linguistics pertains to understanding how the polished, static form of a written text emerges from the messy, moment-by-moment decisions of the writer. While the structures of finished texts have been extensively theorized, and the real-time cognitive processes of writing have been widely studied, the relationship between these real-time processes and the functional linguist

Traits that affect organismal fitness are often highly genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature – after all – ‘selects’ the best genotypes at the expense of those that fall short. Explaining the extensive genetic variation of fitness-related traits is thus a longstanding puzzle in evolutionary

Background and Objectives: Previous studies have suggested associations between pain perception and psychological factors such as mood, distress, fatigue, and quality of life. However, these factors and their relationship to pain sensitivity have typically been investigated in isolation and with insufficient sample sizes. To address these limitations, we examine the interplay between distinct psyc

Considering the distinct etiological pathways and molecular characteristics of different lung cancer subtypes, it is crucial to develop subtype-specific prevention strategies and therapeutic targets. This study aimed to identify protein biomarkers and potential therapeutic targets for specific subtypes of lung cancer by integrating population-based observational studies and Mendelian randomisation

The special degeneracy which occurs in the harmonic-oscillator potential when two of the frequencies have ratios of small integer numbers is exploited. Favored shell energies occur for particle numbers which vary with the third frequency. Applications to realistic nuclear potentials show that this degeneracy leads to special shell effects for axial shapes (1:1 ratio) but also for the 2:1 ratio exe

We study the Coulomb chain where particles are restricted to one dimension and experience three-dimensional Coulomb interactions with their nearest and next-to-nearest neighbours. The distances between consecutive particles are treated as random variables. It is shown that the correlation between clusters of consecutive variables decay exponentially with the number of variables separating them. Th

Integrated Continuous Biomanufacturing reduces manufacturing costs while maintaining product quality. A key contributor to high biopharmaceutical costs, specifically monoclonal antibodies (mAbs), is chromatography. Protein A ligands are usually preferred but still expensive in the manufacturing context, and batch chromatography under-utilizes the columns' capacity, compromising productivity to mai