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Sagarmatha (Everest) has long been recognised as one of the principal goals of global adventure tourism. Supported by high-altitude workers, paying climbers on Sagarmatha have the opportunity to tread in the footsteps of colonial pioneers such as George Mallory and Sir Edmund Hillary. Ever since the first attempt was made to summit Sagarmatha there has been an appreciation amongst the climbing com
Recent years have seen dramatic improvements in computer power, allowing ever more challenging problems to be approached. In light of this, it is imperative to have a quantitative model for examining chemical reactivity, both in the condensed phase and in solution, as well as to accurately quantify physical organic chemistry (particularly as experimental approaches can often be inconclusive). Simi
Non-metropolitan regions are considered more exposed to external shocks than their metropolitan counterparts, while having lower capacities to change. However, there is considerable variation among non-metropolitan regions. We argue that this variation can be captured theoretically by modelling the dynamic interplay between perceived and real opportunity spaces and agency. We empirically analyse r
This article provides a comprehensive overview of digital technologies for water use and management in agriculture, examining recent applications and future prospects. It examines key water-related challenges - scarcity, pollution, inefficient use and climate change - and shows how various digital technologies such as Remote Sensing, Artificial Intelligence, the Internet of Things, Big Data, Robot
Drug-resistant bacterial infections are among the most severe physiological challenges facing human health. Therefore, the detection and inactivation of pathogenic bacteria remains a crucial therapeutic goal in modern society. In this study, we design multifunctional nanocomposites aimed at bacterial binding, fluorescence labeling, and synergistic antibacterial treatment. These nanocomposites are
Climate change poses an existential threat to humanity. It is now indisputable that the primary cause of this threat is human activity resulting in high greenhouse gas (GHG) emissions, which began during the Industrial Revolution and have continued to rapidly accelerate. The first warnings of impending and irreversible climate change were sounded decades ago, when governmental and intergovernmenta
Online Raman scattering and in situ extinction measurement were combined in this work for qualitative and quantitative evaluations of various soot in the aerosol phase with different organic compounds.
Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. All tumors exhibit outlier ALK expression, partly accompanied by intragenic deletions and aberrant splicing resulting in ALK variants that are
Low-and-middle-income countries (LMICs) bear a high burden of intimate partner violence (IPV). However, there are no reviews assimilating the factors affecting risk of IPV in LMICs. This systematic review (2010–20) identifies risk and protective factors of IPV in LMICs. We followed the PRISMA guidelines to review 399 studies and included 32 studies. Studies were of ever-partnered women living in a
To limit global warming to 1.5°C, fossil fuel use must rapidly decline, but historical precedents for such large-scale transitions are lacking. Here we identify 147 historical episodes and policy pledges of fossil fuel decline in 105 countries and global regions between 1960 and 2018. We analyze 43 cases in larger systems most relevant to climate scenarios. One-half of 1.5°C-compatible scenarios e
BACKGROUND: Women living in the Bolivian Andes are environmentally exposed to arsenic, yet there is scarce information about arsenic-related effects in this region. Several biomarkers for telomere length and oxidative stress (mitochondrial DNA copy number, mtDNAcn; 8-Oxo-2'-deoxyguanosine, 8-oxo-dG; and 4-hydroxy nonenal mercapturic acid, 4-HNE-MA) have been previously linked to arsenic, and some
BACKGROUND: Patients presenting with peritoneal metastases (PM) of colorectal cancer (CRC) can be curatively treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Angiogenesis is under control of multiple molecules of which HIF1a, SDF1, CXCR4, and VEGF are key players. We investigated these angiogenesis-related markers and their prognostic value in patient
Doktorsavhandling i Gamla testamentets exegetik. I avhandlingen kartläggs vilka tolkningsstrategier som är tongivande i modern kommentarlitteratur av Psaltarens s.k. 'förbannelsepsalmer,' dvs. bibeltexter som vanligen utelämnas i modernt gudstjänstliv av innehållsliga skäl då de uttrycker den bedjandes önskan om hämnd och/eller våld gentemot fiender. En översikt av den exegetiska diskursen, så somDue to their calls for vengeance and violence the so called imprecatory psalms are generally considered ethically difficult and subsequently omitted from liturgy. This becomes particularly evident in breviaries, such as the Roman Catholic Church’s Liturgy of the Hours, where both entire psalms and individual verses have been omitted. The widespread omission of lament psalms (including imprecatory
A series of samples of vanadia supported on monoclinic zirconia were prepared with nominal loadings from a half up to sixteen theoretical vanadia layers. The samples were characterized with X-ray diffraction, scanning electron microscopy combined with energy dispersive X-ray analysis, high-resolution electron microscopy, Raman and diffuse reflectance infrared spectroscopy, and were used in the oxi
