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BACKGROUND: Programmed death-ligand 1 (PD-L1) expression on tumor cells is associated with poor prognosis in several malignancies, while partly contradictory and inconclusive results have been presented for colorectal cancer (CRC). This study aimed to evaluate PD-L1 as a prognostic biomarker in CRC by comparing three different antibody clones.METHODS: Patients surgically treated for CRC between Ja

Bakgrund För noggrant utvalda patienter med avancerad hjärtsvikt är hjärttransplantation den optimala behandlingen för att förbättra överlevnad och livskvalitet. Men trots detta är sjukligheten fortfarande betydande inom gruppen. Med avhandlingen ville vi undersöka utfallet bland hjärttransplanterade patienter i Sverige med fokus på dödlighet, samsjuklighet och fysiska begränsningar som är relater

Affärsrättsligt Centrum vid Lunds universitet (ACLU) bedriver forsknings- och seminarieverksamhet på centrala förmögenhetsrättsliga områden. En viktig del av den verksamhet som bedrivs inom ACLU är att regelbundet publicera böcker som består av originalbidrag från forskare och praktiker som har anknytning till ACLU. Målsättningen för ACLU:s publikationer är att de ska belysa aktuella och praktiskt

Organizations advocating for the rights of LGBTQIA+ people are found all around the globe. These organizations champion the rights of lesbian, gay, bisexual, transgender, queer, intersex, asexual, aromantic, and agender individuals, with the plus-sign acknowledging those who are part of the community without fitting neatly into any of these specific categories. This entry details the early history

Background: Parkinson's disease (PD) is characterized by alpha-synuclein (α-Syn) pathology, neurodegeneration and neuroinflammation. Human leukocyte antigen (HLA) variants associated with PD and α-Syn specific CD4+ T lymphocytes in PD patients highlight the importance of antigen presentation in PD etiology. The class II transactivator (CIITA) regulates major histocompatibility complex class II (MH

Judging from the steep rise in number of publications in organizational sociology and management studies about “hybrid organizations”, it would seem as if this is either something new or something that has grown in importance in the past decades. In this article, we make a thorough attempt to provide the concept a proper anchoring in sociology and organization studies. We demonstrate that hybridit

Artikeln behandlar utsignalåterkoppling av system där funktionen som avbildar tillstånden på mätsignarlerna har en mängdvärd invers.Vi visar att om mängden har begränsad kardinalitet, så går det att komprimera historiken till en ändlig vektor som beräknas rekursivt.Resultatet exemplifieras på diskrettidsintegratorn där mätsignalen är absolutbeloppet av tillståndet och får fram en förvånandsvärt enThis article considers output-feedback control of systems where the function mapping states to measurements has a set-valued inverse. We show that if the set has a bounded number of elements, then minimax dual control of such systems admits finite-dimensional information states. We specialize our results to a discrete-time integrator with magnitude measurements and derive a surprisingly simple sub

This chapter explores the Danish case of a years-long campaign to phase out the “production” of the fast-growing industrial chicken breed, Ross 308. Core differences between welfarism, new welfarism, and abolitionist positions of rights and liberation are outlined - and it is investigated how activists navigate the tensions between these approaches in practice. The case makes visible a tangled ter

Artikeln behandlar fundamentala prestandabegränsningar för strikt kausala tillståndsskattningar hos linjära system som beskrivs av ett ändligt antal modeller. Systemet antas beskrivas korrekt av en av modellerna, men det är okänt vilken av kandidaterna som är korrekt. Vi ger metoder för att beräkna övre- och undre begränsningar på minimax prestanda, defininerad som förstärkningen från störningar tThis article concerns the performance limits of strictly causal state estimation for linear systems with fixed, but uncertain, parameters belonging to a finite set. In particular, we provide upper and lower bounds on the smallest achievable gain from disturbances to the point-wise estimation error. The bounds rely on forward and backward Riccati recursions-one forward recursion for each feasible m

Introduction: Improvements in virtual reality (VR) have made it possible to create realistic, virtual settings for behavioral assessment and skills training that cannot otherwise be accessed in a safe way in forensic psychiatric settings. VR interventions are under development but little is known how forensic psychiatric patients with severe mental disorders experience VR-assisted assessments or t

Background/Objectives: This study explores the relationship between cognitive performance measured by the Symbol Digit Modality Test (SDMT) and the severity of self-reported head injury, traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), depression, pain, and psychosocial dysfunction in a population of trauma-affected refugees. Refugees, especially those who have been subjected t

Background: Despite efforts to promote guideline use, guideline adoption is often suboptimal due to failure to identify and address relevant barriers. Barriers vary not only between guidelines but also between settings, intended users, and targeted patients. Multi-professional guidelines are often used in child and adolescent mental health services (CAMHS), making the implementation process more d

The paper examines how the increasing datafication of society and advancements in artificial intelligence (AI) offer new empirical opportunities to better understand the Minimum Content of Nationality (MCN). Despite the critical importance of the MCN in statelessness, it has largely been ignored in academic and policy circles. The ambiguity that results from this lack of engagement greatly complic

The minimization of the total variation is a well-established technique of preservingedges and discontinuities. Therefore it has wide applicability in image processing,where one is interested in recovering a corrupted image while preserving edges inthe image. In the last decades, in the literature, there have been introduced manydifferent approaches and algorithms for minimizing the total variatio

Due to its low symmetry, β-Ga2O3 exhibits a strongly anisotropic optical response. As a result, the absorption spectra change with the polarization state of the incoming photons. To understand this phenomenon, here we calculate the complete electromagnetic wave equation solutions as a function of linear polarization angle and photon energy for β-Ga2O3 using its previously measured complex dielectr