Two hundred and eighty‐one patients hospitalized for HF (mean age, 74 years; 32% women) were assessed using cognitive tests: Montreal Cognitive Assessment (MoCA), A Quick Test of Cognitive speed, Trail Making Test A, and Symbol Digit Modalities Test. The mean follow‐up time censored at rehospitalization or death was 13 months (interquartile range, 14) and 28 months (interquartile range, 29), respe

https://www.lupop.lu.se/article/cognitive-test-results-are-associated-mortality-and-rehospitalization-heart-failure-swedish - 2025-09-13

Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Read more at https://journals.sagep

https://www.lupop.lu.se/article/disentangling-social-genetic-rearing-environment-effects-alcohol-use-disorder-using-swedish-national - 2025-09-13

Adult-onset growth hormone deficiency (AGHD) is usually the last deficiency to be substituted in hypopituitarism. In children with documented GH deficiency, treatment without delay is crucial for achieving optimal effects on growth and development. In adults, it is not known whether a delay in treatment initiation influences biochemical response and the favourable physiological effects resulting f

https://www.lupop.lu.se/article/early-versus-late-initiation-gh-replacement-adult-onset-hypopituitarism - 2025-09-13

Rates of knee replacement (KR) are increasing worldwide. Based on population and practice changes, there are forecasts of a further exponential increase in primary knee replacement through to 2030, and a corresponding increase in revision knee replacement. We used registry data to document changes in KR over the past 15 years, comparing practice changes across Sweden, Australia, and the United Sta

https://www.lupop.lu.se/article/increases-rates-primary-and-revision-knee-replacement-are-reducing-15-year-registry-study-across-3 - 2025-09-13

In the annual open call Formas welcomes applications within its three areas of responsibility - Environment, Agricultural Sciences and Spatial Planning. The purpose of the call is to enable researchers to address self-identified research needs and is divided into three sub-calls:Research and development projectsResearch and development projects for future research leadersMobility grantsThe latter

https://www.lupop.lu.se/article/formas-annual-open-call-2018-now-open - 2025-09-13

Influenza may precipitate cardiovascular disease, but influenza typically peaks in winter, coinciding with other triggers of myocardial infarction (MI) such as low air temperature, high wind velocity, low atmospheric pressure, and short sunshine duration. Read more at https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236866

https://www.lupop.lu.se/article/association-acute-myocardial-infarction-influenza-nationwide-observational-study - 2025-09-13

Increased urinary excretion of IgM and low-grade albuminuria are associated with increased risk of cardiovascular morbidity and mortality. The objective of this study was to investigate the association between urinary IgM, albuminuria, and vascular parameters reflecting arterial structure and function. Read more at https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-020-01638-3

https://www.lupop.lu.se/article/patterns-urinary-albumin-and-igm-associate-markers-vascular-ageing-young-middle-aged-individuals - 2025-09-13

An inverse relationship between mental health and academic achievement is a well-known phenomenon in the scientific literature. However, how and when this association develops is not fully understood and there is a lack of longitudinal, population-based studies on young children. Early intervention is important if associations are to be found already during childhood. The aim of the present study

https://www.lupop.lu.se/article/mental-health-and-academic-performance-study-selection-and-causation-effects-childhood-early - 2025-09-13

Intracerebral hemorrhage (ICH) is the most serious adverse effect of oral anticoagulant (OAC) treatment. The effect of OAC reversal therapy on outcome is uncertain. We compared 90-day survival and functional outcome in patients with OAC-ICH who received OAC reversal therapy with those who did not. Read more at https://www.frontiersin.org/articles/10.3389/fneur.2020.00760/full

https://www.lupop.lu.se/article/reversal-treatment-oral-anticoagulant-related-intracerebral-hemorrhage-observational-study-based - 2025-09-13

Sport‐related concussions are an increasingly recognized health problem. Soccer is the most popular sport in the world although recent studies on concussion incidence are scarce. Here, a nationwide prospective study on concussion incidence, symptom severity, risk factors, gender differences, and return‐to‐play after concussion was performed in 51 Swedish elite soccer teams during the 2017 season.

https://www.lupop.lu.se/article/concussion-incidence-and-recovery-swedish-elite-soccer-prolonged-recovery-female-players - 2025-09-13

The study population included adults (n = 434,542) aged 30 years or older with DM followed from 2005 to 2015 in Sweden for incident HF. The association between neighborhood deprivation and the outcome was explored using Cox regression analysis, with hazard ratios (HRs) and 95% confidence intervals (95% CIs). All models were conducted in both men and women and adjusted for age, educational level, f

https://www.lupop.lu.se/article/association-between-neighborhood-deprivation-and-heart-failure-among-patients-diabetes-mellitus-10 - 2025-09-13

Theme: "The future of Swedish register-based research" By the end of 2018 the Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM), funded by the Swedish Research Council, has been active for 10 years. This will be acknowledged by a free open national one-day symposium in Stockholm 16 May reflecting on how the achievements and experiences of SIMSAM and other par

https://www.lupop.lu.se/article/10-year-symposium-simsam - 2025-09-13

Consecutive patients with early RA (symptom duration <12 months) were followed according to a structured programme and examined with dual-energy X-ray absorptiometry (DXA) at inclusion and after 2, 5 and 10 years. Mean Z-scores over the study period were estimated using mixed linear effect models. Changes in Z-scores between follow-up visits were analysed using paired T-tests. New publication in R

https://www.lupop.lu.se/article/changes-bone-mineral-density-over-10-years-patients-early-rheumatoid-arthritis - 2025-09-13

It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. New publication in JAHA

https://www.lupop.lu.se/article/risk-stroke-patients-atrial-fibrillation-associated-stroke-siblings-nationwide-study - 2025-09-13

We performed whole-exome sequencing in 22 probands, under 56 years at their first ischemic stroke episode, from multi-incident stroke families. With the use of a comprehensive stroke-gene panel, we searched for variants in stroke-related genes. The probands’ clinical stroke subtype was related to clinical characteristics previously associated with pathogenic variants in these genes. New publicatio

https://www.lupop.lu.se/article/whole-exome-sequencing-22-young-ischemic-stroke-patients-familial-clustering-stroke - 2025-09-13

Chills and vomiting have traditionally been associated with severe bacterial infections and bacteremia. However, few modern studies have in a prospective way evaluated the association of these signs with bacteremia, which is the aim of this prospective, multicenter study. Patients presenting to the emergency department with at least one affected vital sign (increased respiratory rate, increased he

https://www.lupop.lu.se/article/risk-bacteremia-patients-presenting-shaking-chills-and-vomiting-prospective-cohort-study - 2025-09-13

Disease prevalence proportions were generally underestimated in the absence of IPPW but became markedly closer to population values after IPPW using sociodemographic variables. We found limited evidence of selective participation bias in association estimates, but IPPW improved external validity when bias was present. New publication in Journal of Clinical Epidemiology

https://www.lupop.lu.se/article/participation-weighting-based-sociodemographic-register-data-improved-external-validity-population - 2025-09-13

Polypharmacy and excessive polypharmacy were evaluated using data extracted from the Swedish Prescribed Drug Register between 2006 and 2014. Polypharmacy was defined as being exposed to five or more drugs and excessive polypharmacy was defined as being exposed to 10 or more drugs during 1 month respectively. Average annual percent change (AAPC) was calculated using Joinpoint Statistical Software.

https://www.lupop.lu.se/article/increasing-trend-prevalence-polypharmacy-sweden-nationwide-register-based-study - 2025-09-13

Obesity among children and adolescents is a worldwide public health concern. Type 1 diabetes (T1D) and type 2 diabetes (T2D) incidence are increasing, with heredity and socioeconomic status as possible risk factors. How these factors affect the risk of childhood obesity remains unclear. The aim of this study was to investigate the association between obesity and parental diabetes among 12-year-old

https://www.lupop.lu.se/article/impact-parental-diabetes-prevalence-childhood-obesity - 2025-09-13

The world of sports has a complex association to problem gambling, and the sparse research examining problem gambling in athletes has suggested an increased prevalence and particularly high male predominance. The present study aimed to study frequency and correlates of problem gambling in populations with moderate to high involvement in fitness or physical exercise. New publication in Int J. Envir

https://www.lupop.lu.se/article/problem-gambling-fitness-world-general-population-web-survey - 2025-09-13