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We propose a machine learning-enhanced chemistry coordinate mapping (CCM) method that accelerates the integration of detailed chemical kinetics in reactive flow simulations by grouping chemically similar computational cells into clusters/zones within a low-dimensional latent space. Unlike original CCM methods that rely on manually selecting latent variables, our approach automatically discovers co
Background: Graft rejection (GR) is common complication after haploidentical hematopoietic cell transplantation (haplo-HCT). There are only a few studies describing the clinical presentation and potential risk factors of GR, and the optimal rescue strategy is not established. Objectives: To evaluate the cumulative incidence and potential risk factors for GR following haplo-HCT, and to compare surv
The relation between moisture content of a material and the ambient climate is described by sorption isotherms. Several models for prediction of sorption isotherms exist in the hygroscopic moisture range, but models of sorption isotherms in the over-hygroscopic range are less abundant. In wood, water can be present both in the solid cell wall and in the macro voids (e.g. cell lumina, pit chambers)
Iron has many important functions related to energy metabolism. However, hemoglobin synthesis is always a priority. Iron deficiency can be caused by increased loss, insufficient intake, or decreased absorption from the intestine and reduced release from depots in systemic inflammation. Anemia appears when stores are depleted or when utilization of iron from the stores is impaired. Treatment with o
Histatins are a family of multifunctional, cationic histidine-rich saliva peptides. The most prominently represented are Histatin 1, Histatin 3, and Histatin 5. Despite considerable similarities in primary structure, the three members are known to display varied antimicrobial properties and healing abilities. This study aims to provide a detailed structural comparison of Histatin 1, Histatin 3, an
The largest reservoir of carbon in protoplanetary discs is stored in refractory organics, which thermally decompose into the gas phase at the organics line located well into the interior of the water iceline. Because this region is so close to the host star, it is often assumed that the released gaseous material is rapidly accreted and has little effect on the evolution of the disc composition. Ho
Chemical communication using pheromones is crucial for the reproductive success of many insect species, including beetles(Coleoptera). Pheromones are detected by specialised odorant receptors (ORs), called pheromone receptors (PRs), in the sensoryneurons of the antennae. The PRs in Coleoptera remain understudied, with only a few receptors being functionally characterised.This limits our understand
Before performing 177Lu-DOTATATE therapy for neuroendocrine tumors, somatostatin receptor (SSTR) PET imaging is currently used to confirm sufficient tumor SSTR expression, but it also has potential to be used to personalize treatment by predicting absorbed doses to critical organs. This study aims to validate the predictive capability of SSTR PET in anticipating renal absorbed dose in the first cy
Objectives To study the prevalence of and interplay between common neuropsychiatric sequelae 3-4 years after onset of first-ever stroke - specifically post-stroke fatigue (PSF), post-stroke depression (PSD) and post-stroke cognitive impairment (PSCI). Design Population-based cohort study. Setting Catchment area of a Swedish University Hospital. Participants We recruited individuals with first-ever
This work aims to differentiate strangeness produced from hard processes (jetlike) and softer processes (underlying event) by measuring the angular correlation between a high-momentum trigger hadron ((Formula presented)) acting as a jet proxy and a produced strange hadron [(Formula presented) meson]. Measuring (Formula presented) correlations at midrapidity in (Formula presented)-Pb collisions at
(Formula presented) boson events at the Large Hadron Collider can be selected with high purity and are sensitive to a diverse range of QCD phenomena. As a result, these events are often used to probe the nature of the strong force, improve Monte Carlo event generators, and search for deviations from standard model predictions. All previous measurements of (Formula presented) boson production chara
Objective: It has been reported that metastatic lymph nodes can be present in the parauterine lymphovascular (PULT) and in lateral paracervical lymphatic tissue as in-transit disease in patients with cervical cancer. This study aimed to clarify the understanding of in-transit positive lymph nodes in PULT and lateral paracervix and its clinical management in patients with cervical cancer, based on
Background: The 313-variant polygenic risk score (PRS313) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS313 across different European populations which could influence risk estimation has not been performed. Methods: We explored the distribution of PRS313 across European populations using genotype data from 94,072 females without breast cancer
Soft pair potentials predict a reentrant liquid phase for high concentrations, a behavior not observed experimentally. Here, very soft microgels confined at an oil-water interface are used as a model system of particles interacting via a soft potential in 2D. Interfacial rheology measurements demonstrate the existence of different flow regimes that depend on the compression of the monolayer. Such
Using a mixed-methods approach, we assessed understanding of risks from exposure to the non-threshold carcinogen hexavalent chromium (Cr(VI)) among workers (n = 113) and occupational health and safety managers (n = 13) at 14 worksites with potential exposure to Cr(VI). We found that 55% of the workers had a measurable concentration of inhalable Cr(VI), with 19% exceeding 1 µg/m3, a level that corr
Fire is a pivotal aspect of human involvement in the carbon cycle. However, the precise timing of the large-scale human fire use remains uncertain. Here, we report a pyrogenic carbon record of East Asian fire history over the past 300,000 y from the East China Sea. This record suggests a rapid increase in fire activity since approximately 50,000 y ago, indicating a decoupling from the monsoon clim
This study focuses on understanding how archaeologists interact with and reuse 3D data during excavation, drawing on an ad-hoc experiment and a discourse analysis approach taken from socio-linguistic disciplines. The experiment, conducted during the excavation of an Iron Age ‘central place’ in Sweden, reveals the multifaceted utility of 3D models in archaeological discussions. Our analysis shows t
