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Evidence on the predictive ability of risk assessment models for event-free survival (EFS) in patients with pulmonary arterial hypertension is scarce. We aimed to investigate the relationship between risk status at 6 months after diagnosis (6 M) and EFS, by three risk models: Multicomponent Improvement (MCI), ESC/ERS 4-Strata Risk (4SR), and noninvasive French PH Registry Score (FRS). Data collect
The bar pattern speed of the Large Magellanic Cloud (LMC) has been measured using Gaia data, suggesting the presence of a slow pattern that is perhaps not rotating at all. Numerical simulations of interacting LMC-SMC systems were able to reproduce a bar stoppage. Here, we report on the first measurement of the bar pattern speed of the LMC as a function of the evolutionary phase of its stellar popu
The 13th century AD in southern Africa is a period associated with the emergence of class-based society and the establishment of Mapungubwe as the capital of a regional state. This study reports on ceramics excavated from four households at Bosbokpoort, a small Mapungubwe settlement situated approximately 95 km from Mapungubwe. By combining traditional stylistic analysis with chemical (pXRF) and m
Purpose of Review: This paper aims to evaluate the burden of contact allergy caused by cosmetic products, identifying the key allergens involved and examining recent regulatory and diagnostic developments. The review addresses which substances commonly induce allergic contact dermatitis and how current trends and emerging allergens impact clinical practice. Recent Findings: Fragrances remain the m
Context. Ultra-hot Jupiters (UHJs) in close orbits around early-type stars provide natural laboratories for studying atmospheric escape and star-planet interactions under extreme irradiation and wind conditions. The near-ultraviolet (NUV) regime is particularly sensitive to extended upper atmospheric and magnetospheric structures. Aims. We investigate whether star-planet interactions in the WASP-1
INTRODUCTION: The independent contributions of baseline and longitudinal tau positron emission tomography (PET) and magnetic resonance imaging (MRI) to cognitive decline remain unclear. METHODS: We included n = 761 amyloid-positive individuals from the Swedish BioFINDER-2 study with [18F]RO948-tau-PET, 3-Tesla structural-MRI, and cognition (n = 322 with longitudinal imaging data). Linear-mixed-mod
Let v1 and v2 be two distinct vertices of an equilateral tree T0. Let ϕN(i) (i=1,2) be the characteristic functions of the Sturm-Liouville problem on T0 rooted at vi with Neumann conditions at the root and let ϕD(i) (i=1,2) be the characteristic functions of the Sturm-Liouville problem on T0 with Dirichlet conditions at the root. We prove that if attaching any tree to T0 at the vertices v1 and v2
Empiric combination antibiotic therapy (ECAT) is commonly used to treat healthcare-associated bloodstream infections (HA-BSIs) and sepsis. However, the level of supporting evidence is low and clinical practice varies significantly. We conducted a post hoc analysis using the EUROBACT-2 international cohort study database, which contained data on 2406 adult patients from 328 intensive care units (IC
This study evaluates how well five Regional Climate Model (RCM) projections at resolutions from 44 km to 3 km reproduce wet and dry spells compared with observations at six locations in Scania, southern Sweden. Future changes in general and extreme wet and dry signals were also analyzed under RCP8.5 to the end of the 21st century. Convection-permitting climate models (CPMs), operating at resolutio
Manganese tetra-pyridyl-porphyrins are found to self-organize in an ordered monolayer on graphene. Moreover, post deposition of cobalt ad-atoms steers the geometric reordering of the layer, yielding the formation of a self-assembled bimetallic network, where both Mn and Co are tetra-coordinated with nitrogen. While manganese shifts from Mn(ii) towards the +2/+3 oxidation state range, depending on
Ecologists have long proposed that environments providing more energy can support more species, yet empirical evidence frequently contradicts this expectation. We argue that such inconsistencies result from confounding geographical influences that mask the true relationship between species richness and energy-related factors. Here, by comparing species richness across different climate conditions,
Background: The optimal timing of oral anticoagulation for prevention of early ischaemic stroke recurrence in people with acute ischaemic stroke and atrial fibrillation remains uncertain. We aimed to estimate the effects of starting a direct oral anticoagulant (DOAC) early (≤4 days) versus later (≥5 days) after onset of ischaemic stroke. Methods: For this systematic review and meta-analysis we sea
Introduction Despite an increasing amount of research related to gender-affirming treatment (GAT) outcomes among transgender and gender-diverse (TGD) people (ie, people who experience discomfort or distress in the misalignment between their gender and sex assigned at birth) in recent years, the evidence base for current recommendations is suboptimal. One contributing factor is the heterogeneity in
A new, striking species of satyrine butterfly, Lymanopoda chysquyco sp. nov. (Nymphalidae, Satyrinae, Satyrini, Pronophilina) is described from the Páramo de Guerrero, the northern extremity of high-altitude grasslands in the Colombian Eastern Cordillera. Among approximately 70 known Lymanopoda species, only five exhibit blue colour on the upperside of their wings, with no evidence of close relati
This study investigates “stiffness” optimization of path-dependent elasto-plastic structures by comparing the traditional secant stiffness formulation with a novel tangent stiffness formulation. Design updates are generated using the gradient-based Method of Moving Asymptotes (MMA), and the material behavior is modeled and limited to small-strain elasto-plasticity and isotropic hardening. Numerica
Long- and short-range correlations for pairs of charged particles are studied via two-particle angular correlations in pp collisions at s = 13 TeV and p–Pb collisions at sNN = 5.02 TeV. The correlation functions are measured as a function of relative azimuthal angle ∆φ and pseudorapidity separation ∆η for pairs of primary charged particles within the pseudorapidity interval |η| < 0.9 and the trans
A search is conducted for new phenomena in events with a top quark pair and large missing transverse momentum, where the top quark pair is reconstructed in final states with one isolated electron or muon and multiple jets. The search is performed using the Large Hadron Collider proton-proton collision data sample at a centre-of-mass energy of s = 13 TeV recorded by the ATLAS detector that correspo
