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BACKGROUND: Activated protein C (APC) inhibits coagulation by degrading activated factor V (FVa) and factor VIII (FVIIIa), protein S (PS) functioning as a cofactor to APC.METHODS: By mutagenesis of the vitamin K-dependent Gla domain of APC, we have recently created an APC variant having enhanced anticoagulant activity due to increased affinity for negatively charged phospholipid membranes. In the
Causal relations between knowledge-intensive business services and regional employment growth. Regional Studies. This paper studies the causal relations between regional employment growth in knowledge-intensive business services (KIBS) and overall regional employment growth using German labour-market data for 1999–2012. Adopting a recently developed technique, it uses a structural vector autoregre
The integrated system is subdivided into five systems -- production planning, production supervising, process control, quality control and reporting. This report deals with quality control and presents the system for sampling and testing and the mathematical models used to describe the variations in quality variables. The design of estimators, predictors and interpolators using Kalman’s method is
In this paper, we show how to consistently price cash settled Internal Rate of Return (IRR)-swaptions and derivatives on these contracts. There are several results worth highlighting. First, if we know at what fixed coupon an IRR-swap values to par, we can compute the price of any IRR-swaption in a way consistent with absence of arbitrage. We show that this fixed coupon, denoted the IRR-forward, c
The study analyzed the situational characteristics of 112 incidents where police used firearms to handle high threat situations. Most shooting incidents emanated from usually uneventful tasks, e.g., handling burglaries or disturbances. The assailants were commonly armed with firearms (26%), sharp (27%) or blunt objects (10%). The incidents were regularly short-lasting (in 39% were shots fired ≤3 s
During the 1970s, pornographic magazines that envisioned the Finnish man sovereignly enjoying sexual pleasures in Eastern Europe, the Soviet Union, the Middle East, and the Far East became extremely popular in Finland. In this article it is argued that pornographic magazines functioned as geographical as well as sexual maps; through the medium of magazines, Finnish readers were educated to think o
Immune checkpoint inhibitors (ICPI), such as ipilimumab [anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibody] and nivolumab or pembrolizumab [anti-programmed cell death protein-1 (PD-1) antibodies], improve survival in several cancer types. Since inhibition of CTLA-4 or PD-1 leads to non-selective activation of the immune system, immune-related adverse events (irAEs) are frequent. Enterocoliti
Preclinical studies suggest that stem cell therapy (SCT) may improve sensorimotor recovery after stroke. Upper extremity motor impairment (UEMI) is common after stroke, often entailing substantial disability. To evaluate the feasibility of post-stroke UEMI as a target for SCT, we examined a selected sample of stroke patients potentially suitable for SCT, aiming to assess the frequency and recovery
A family history of cutaneous melanoma ('melanoma') is a well-established risk factor for melanoma. However, less is known about the possible familial associations of melanoma with other discordant cancers. A risk for discordant cancer may provide useful information about shared genetic and environmental risk factors and it may be relevant background data in clinical genetic counseling. Using the
In this study, a global vegetation model (LPJ-GUESS) is forced with spatial information (Nomenclature of Units for Territorial Statistics (NUTS) 2 level) of land-use intensity change in the form of nitrogen (N) fertilization derived from a model chain which informed the Common Agricultural Policy Regionalized Impact (CAPRI) model. We analysed the combined role of climate change and land-use intens
Psychological stress has been reported as a possible trigger of atrial fibrillation (AF). No studies have investigated whether any association between stress and AF could be modified by genetic susceptibility to AF (AF-genetic risk score (AF-GRS)). 8765 men and 13,543 women from the Malmö Diet Cancer Study, a population-based cohort, were included in the analyses. A variable representing stress wa
Background: Effects of increased adenosine dose in the assessment of fractional flow reserve (FFR) were studied in relation to FFR results, hemodynamic effects and patient discomfort. FFR require maximal hyperemia mediated by adenosine. Standard dose is 140 μg/kg/min administrated intravenously. Higher doses are commonly used in clinical practice, but an extensive comparison between standard intra
Objective: The use of a conduit is an established surgical method for reconstruction of the right ventricular outflow tract in congenital heart disease; however, its limited durability makes reintervention almost inevitable. We studied the trends in new implantation, reoperation, and transcatheter pulmonary valve replacement (TPVR) from a Swedish national perspective. Design and results: The Swedi
Background:Chemotherapy in platinum-resistant ovarian cancer (PROC) aims for palliation and prolonging of progression-free survival (PFS). This study compares Health-related Quality of Life (HRQoL) and efficacy between single-agent chemotherapy and tamoxifen in PROC.Methods:Patients with PROC were randomised (2: 1) to chemotherapy (weekly paclitaxel 80 mg m -2 or four weekly pegylated liposomal do
Bioclimatic indices for use in studies of ecosystem function, species distribution, and vegetation dynamics under changing climate scenarios depend on estimates of surface fluxes and other quantities, such as radiation, evapotranspiration and soil moisture, for which direct observations are sparse. These quantities can be derived indirectly from meteorological variables, such as near-surface air t
This thesis is a study of the phenomenon modern furniture classics in a contemporary Swedish context. Classics have a strong and normative position in the world of design, and what the concept of modern furniture classic entails is often taken for granted and rarely problematised. The main objectives of the study is to investigate what a modern furniture classic is and how it attains the status of
