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Studies have shown a causal link between high-calorie diet (HCD) and colon cancer. However, molecular mechanisms are not fully elucidated. To understand etiology of HCD-induced colon carcinogenesis, we screened 10 pathways linked to elevated colonic cell proliferation and chronic inflammation in an HCD-consuming human-relevant pig model. We observed elevated colonic mucosal interleukin-6 (IL-6) ex

When an intense laser pulse interacts with a solid surface, ions get accelerated in the laser-plasma due to the formation of transient longitudinal electric field along the target normal direction. However, the acceleration is not mass-selective. The possibility of manipulating such ion acceleration scheme to enhance the energy of one ionic species (either proton or carbon) selectively over the ot

Although significant improvements have been made in the treatment of acute lymphoblastic leukemia (ALL), there is a substantial subset of high-risk T-cell ALL (T-ALL) patients with relatively poor prognosis. Like in other leukemia types, alterations of the PI3K/mTOR pathway are predominant in ALL which is also responsible for treatment failure and relapse. In this study, we show that relapsed T-AL

Psychosis patients have increased prevalence of metabolic disorders, which increase the risk for cardiovascular disease. Elevated troponin T level is an early biomarker of cardiovascular damage. We tested for association between troponin T levels and genetic risk variants of elevated blood glucose level in psychosis. Glucose and troponin T levels correlated positively. MTNR1B rs10830963 and NOTCH2

The use of 18S rDNA sequences for inferring phylogenies, in particular for higher taxonomic level analysis, has a long tradition in phycology. Similar to ITS2, the 18S rDNA displays a conserved secondary structure that could be used simultaneously with the primary sequence to increase the amount of information used when inferring phylogenetic relationships. Sequence-structure phylogenetics is alre

We present an iterative retrieval algorithm based on data constraint for ultrashort pulse characterization using dispersion scan (d-scan). The proposed algorithm is much faster and leads to a drastic reduction of retrieval times, but, compared to the standard algorithm, it performs less robustly in the retrieval of noisy d-scan traces. The algorithm is tested on several simulated cases and in two

The objective of this study is to explore mechanisms for ignition and extinction for condensed-phase fuels via the use of a gas-fueled burner. Flames were generated with a porous 25 mm circular burner using mixtures of methane and propane with nitrogen. The procedure was to specify a set of mass fluxes of nitrogen-fuel mixture that corresponded to the flash- fire- and extinction points and for the

Aim: Delayed cerebral hypoperfusion is a secondary complication found in the days after transient global cerebral ischaemia that worsens the ischaemic damage inflicted by the initial transient episode of global cerebral ischaemia. A recent study demonstrated increased cerebral vasoconstriction in the large arteries on the brain surface (pial arteries) after global cerebral ischaemia. However, smal

This paper presents an adaptive QR decomposition (QRD) processor for five-band carrier aggregated LTE-Adownlinks. The design uses time and frequency correlationproperties of wireless channels to reduce QRD computationswhile maintaining an uncoded bit error rate loss below 1 dB.An analysis on the performance of a linear interpolating QRD ispresented and optimum distances for different channel condi

Event detection is a challenging stage in eye movement data analysis. A major drawback of current event detection methods is that parameters have to be adjusted based on eye movement data quality. Here we show that a fully automated classification of raw gaze samples as belonging to fixations, saccades, or other oculomotor events can be achieved using a machine-learning approach. Any already manua

The post-2015 developmental agenda and the SDGs have been formulated to advance holistic global progress and enable the adoption of quantitative targets for all countries by recognizing their respective national realities and capacities. This research examines how global ambitions can guide national policy formulation by selecting the Italian Republic and the People's Republic of Bangladesh as mod

Every year in December to February the dust laden Harmattan blows from Sahara towards southwest to the countries along the east west going coast of the Gulf of Guinea. Only few investigations have quantified external dust deposition in forests and plantations in that region and hereby the nutrient input by dust. This paper investigates three different methods for sampling and quantifying dust depo

We have studied the diffusive mobility of hydrogen molecules confined in different size cages in clathrate hydrates. In clathrate hydrate H2 molecules are effectively stored by confinement in two different size cages of the nano-porous host structure with accessible volumes of about 0.50 and 0.67 nm diameters, respectively. For the processes of sorption and desorption of the stored hydrogen the di

Extreme climatic events, such as heat waves, are predicted to increase in frequency and intensity during the next hundred years, which may accelerate shifts in hydrological regimes and submerged macrophyte composition in freshwater ecosystems. Since macrophytes are profound components of aquatic systems, predicting their response to extreme climatic events is crucial for implementation of climate

The world of information is literally at one’s fingertips, allowing access to previously unimaginable amounts of data, thanks to advances in wireless communication. The growing demand for high speed data has necessitated theuse of wider bandwidths, and wireless technologies such as Multiple-InputMultiple-Output (MIMO) have been adopted to increase spectral efficiency.These advanced communication t

Tropical forest productivity is sustained by the cycling of nutrients through decomposing organic matter. Arbuscular mycorrhizal (AM) fungi play a key role in the nutrition of tropical trees, yet there has been little experimental investigation into the role of AM fungi in nutrient cycling via decomposing organic material in tropical forests. We evaluated the responses of AM fungi in a long-term l

In a sample data system we are essentially restricted to control signals which are constant over the sampling interval. The purpose of this report is to analyze the effect of this restriction. The situation where the admissible control signals are piecewise continuous is used as a reference case and the problem is approached from a variational formulation of the control problem where the object of

Herein we present a chimeric recombinant spider silk protein (spidroin) whose aqueous solubility equals that of native spider silk dope and a spinning device that is based solely on aqueous buffers, shear forces and lowered pH. The process recapitulates the complex molecular mechanisms that dictate native spider silk spinning and is highly efficient; spidroin from one liter of bacterial shake-flas

Background: Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain homeostasis of normal tissues. Here, we screened the expression of homeobox genes in mammary stem cells to establish their role in stem cells transformation in breast cancer. Met