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Popular Abstract in Swedish Pyrimidiner är DNA-byggstenar som är essentiella för cellens överlevnad och delning. I mänskliga celler finns pyrimidiner att tillgå antingen genom återupptag eller genom biosyntes (nysyntes). Biosyntesen av pyrimidiner sker i flera steg och i ett av dem spelar enzymet Dihydroorotat dehydrogenas (DHODH) en avgörande roll genom att katalysera en oxidationsreaktion. När cIn the first part of the PhD work, small chemical entities (fragments) found to inhibit human dihydroorotate dehydrogenase (DHODH), were chemically optimized. As part of an ample program at Active Biotech to find new drugs against autoimmune diseases, expanded fragments were repeatedly designed, synthesized and evaluated in a human DHODH assay. Potent inhibitors were identified within three classe

Force feedback (FF) is a technology which is very interesting in the context of human machine interfaces. This as it is usable as a haptic interface, which makes it possible to model and simulate objects and textures. One problem with haptic FF devices today is that most of them are of professional or research standard, which makes them expensive. The technology of FF have also been introduced in

Socware is the name for a new design cluster in Sweden, which intends to unify university, research institutes, and industry towards a common goal, namely System-on-Chip, In this paper one of the programs within the cluster, the Socware Research & Education program, is presented. The program aims to organize a new education curriculum for System-on-Chip design. The education is directed to und

This paper compares grammatical and pragmatic development in foreign language learners of Swedish. For the analysis of grammatical proficiency, data from translation tasks and essays were tested against the stage model proposed in Processability Theory, which identifies five stages of morpho-syntactic development for Swedish (Pienemann 1998, Pienemann and Håkansson 1999). For the pragmatic analysi

Magnetic fields play a central role in the atmospheric properties and variability of active M dwarfs. Information on the strength and structure of magnetic fields in these objects is vital for understanding dynamo mechanisms and magnetically-driven activity of low-mass stars, and for constraining theories of star formation and evolution. We have initiated the first systematic high-resolution surve

Laser diagnostics have become state of the art tools for locally measuring droplet size, velocity and temperature in atomizing sprays. However, when applied in optically dense situations, these techniques suffer from measurement errors induced by unwanted effects such as laser intensity reduction along the path of propagation (light extinction), attenuation in signal intensity collected by the det

Software development organizations are continuously looking for better ways to manage their projects. An emerging approach to achieve this is Inner Source, which refers to the adoption of Open Source development practices within the confines of an organization. With an Inner Source approach, individuals, teams, and departments within an organization can start software projects, very similar to the

Multiple gene expression can be introduced in a yeast strain with using only two markers by means of the two new vectors described, the expression vector pB3 PGK and the CRE recombinase vector pCRE3. The pB3 PGK has a zeocin-selectable marker flanked by loxP sequences and an expression cassette consisting of the strong PGK1 promoter and the GCY1 terminator. The gene of interest (YFG1) is cloned be

The aim of this study was to analyse physico-chemical properties of some complex liquids using the Poisson-Boltzmann (PB) cell model; to extend the theory to cover bilayer systems with complex global geometry; finally to apply this new extended model to such bilayer systems. The PB cell model provides a practical tool to examine counterion association and phase behaviour for structures of simple