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Redox control of exocytosis - Regulatory role of NADPH, thioredoxin, and glutaredoxin

Cellular redox state is an important metabolic variable, influencing many aspects of cell function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH as a candidate signaling molecule for exocytosis in neuroendocrine cells. In pancreatic beta-cells, glucose acutely raised the NADPH-to-NADP(+) ratio and stimulated insulin release in parallel. Furthermore, intracel

Countercurrent Distribution of Lymphocytes from Human Peripheral Blood in an Aqueous Two-Phase System : I. Separation into Subsets of Lymphocytes Bearing Distinctive Markers’

Lymphocytes from human peripheral blood have been separated by countercurrent distribution in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000 with a cell yield of 59–88% and viability above 90%. A highly reproducible partition pattern was seen with four distinct peaks. Lymphocytes with surface membrane immunoglobulin (SmIg) were located in the first part o

TRIPS and Technology Transfer

Abstract in UndeterminedTRIPS is a trade-off between the interest of the developed world in having its technology respected and the need for technology transfer especially to the least-developed countries. But this balance of interests is poorly expressed in the Agreement, which is primarily devoted to protection of intellectual property rights and only marginally addresses the other side of the c

Dry release of suspended nanostructures

A dry release method for fabrication of suspended nanostructures is presented. The technique has been combined with an anti-stiction treatment for fabrication of nanocantilever based nanoelectromechanical systems (NEMS). The process combines a dry release method, using a supporting layer of photoresist which is removed using oxygen ashing in a reactive ion etcher (RIE), with CHF3 plasma induced de

Using AquaCrop for Irrigation and water productivity assessment of Table grapes in arid region of Mexico

The aim of this work is to use the AquaCrop model for irrigation and water productivity assessment of Table grapes in arid region of Mexico during 2005 and 2006 cropping seasons. The irrigation efficiency was investigated by comparing the irrigation scheduling design used by the farmer to the AquaCrop model recommendations. Data analysis showed that the farmer irrigates almost every day, which res

Från förening till företag - Sportslig kontra ekonomisk framgång

Syftet med uppsatsen är att undersöka vad framgång är i dagens skandinaviska elitfotbollsklubbar och vilka strategier som är användbara för att uppnå denna. Uppsatsen ämnar således belysa och klargöra de viktigaste aspekterna i en lyckad strategi inom en modern skandinavisk fotbollsklubb. Med denna kunskap har vi för avsikt att återge en bild över hur en elitfotbollsklubb strategiskt bör organiser

Central bank power is a matter of faith

This paper reconsiders how central banks get involved in the process of determining nominal variables such as market interest rates and inflation rates. It is argued that the traditional story deriving central bank power from its monopoly of issuing base money is flawed. That story - in its various guises - is based on the quantity equation. This equation, however, is only applicable in the hypoth

Technological systems and development blocks

Successful technological transitions require the alignment of technologies, capabilities, infrastructure, and institutions across a wide array of industries and involving many agents. In such processes, synergies and complementarities across different fields of economic activity are crucial. When such complementarities are missing, imbalances emerge, which, in the absence of innovation, may stifle

Hamed Sabahno

Universitetslektor Kontaktinformation E-post: hamed [dot] sabahno [at] stat [dot] lu [dot] seOrganisation Statistiska institutionen Hämtställe: 10 WebbplatsHamed Sabahnos profil i Lunds universitets forskningsportal Publikationer Visar av publikationer. Sorterade efter år och sen titel. Filtrera efter typ AllaArtikel i tidskriftKonferensbidrag Filtrera A CNN Approach for Simultaneous Spatiotempora

https://www.ehl.lu.se/hamed-sabahno - 2026-04-24

Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics

Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de

Transposable Elements in Neural Progenitor Cells

More than 90% of DNA does not code for proteins and for a long time these sequences were referred to as “junk DNA” due to their unknown purpose. With the advent of new technologies it is now known, that the non-coding part of the genome is of great importance for regulating gene expression and is therefore indispensable. Transposable elements comprise about 50% of the genome and co-exist as symbio

Oral treatment with a vitamin D3 analogue (BXL628) has anti-inflammatory effects in rodent model of interstitial cystitis

To investigate the effects of a vitamin D3 analogue (BXL628) in a model of chronic cystitis, as calcitriol analogues might be an interesting new therapeutic option for interstitial cystitis, for although the cause of the disease remains unclear, the increase in mast cells in the mucosa and detrusor muscle are significant. We devised a mouse model of allergen-induced allergic cystitis that is assoc

Antibodies specific for the antigenic domain 1 of glycoprotein B (gpUL55) of human cytomegalovirus bind to different substructures

Glycoprotein B (gB, gpUL55) is a major antigen for the induction of neutralizing antibodies against human cytomegalovirus, making it an attractive antigen for active and passive immunoprophylaxis. The immunodominant region on gB is the antigenic domain 1 (AD-1), a complex structure which requires a minimal linear amino acid sequence of more than 75 amino acids (aa 552-635) for antibody binding. We

Purification of streptococcal protein G expressed by Escherichia coli by high performance liquid affinity chromatography using immobilized immunoglobulin G and albumin

A one-step HPLC method was developed for the purification of protein G, a cell wall molecule from group C and G streptococci with immunoglobulin G- and albumin-binding properties. Lysed Escherichia coli bacteria infected with lambda-phages containing the protein G gene from group G streptococci were used as a starting material for the preparations. The lysate was applied to a column with immobiliz

Antibody-dependent allostery of the M1 protein

Den förrädiska antikroppen Streptokocker är en lömsk bakterie som har många olika sätt att ta sig runt vårt immunförsvar. Den kan låtsas vara en del av vår kropp genom att klä sig själv i en proteinkapsel som är väldigt likt ett mänskligt protein, bryta ned våra celler med hjälp av utsöndrade gifter och använda vårt immunförsvar mot oss genom att binda antikroppar till sig själv. En virulensfaktoThe Group A streptococcus (GAS) (Streptococcus pyogenes) is a significant human pathogen known for causing a diverse range of diseases, spanning from mild diseases such as pharyngitis to life-threatening diseases such as necrotizing fasciitis. Its virulence comes from a plethora of immune evasion mechanisms, but the M protein with its hypervariable region and ability to bind human proteins, stands

Silver rings and marten skins : Contacts between the Volga Region and the Baltic in the early Viking Age

Viking Age silver is a useful tool for tracing various aspects of the society. Contact networks, trade organization, society structure, economic variation etc. This paper concentrates on the so-called Permian rings, which appear in Scandinavian silver hoards from Early Viking Age. Their main concentration is, however, in the regions west of the Ural Mountains in Russia. As the rings found in Russi

2023-09-25 LSK-protokoll-webb

2023-09-25 Protokoll LSK Sida 1 av 5 Lokal skyddskommitté PROTOKOLL Diarienummer V 2023/2095 Datum 2023-09-25 Protokoll lokal skyddskommitté Närvarande Karin Hall, stf ordförande Catrin Malmström, kansli N, ledamot Jessica Abbott, biologiska institutionen, ledamot Leif Bülow, kemiska institutionen, ledamot Magnus Alsterfjord, huvudskyddsombud Bengt Meuller, över- och huvudskyddsombud Carina Rasmus

https://www.naturvetenskap.lu.se/internt/sites/naturvetenskap.lu.se.internt/files/2023-12/2023-09-25%20LSK-protokoll-webb.pdf - 2026-04-24

On Degradation and Monitoring Tools for Gas and Steam Turbines

Popular Abstract in Swedish Elmarknadens avreglering har medfört att behovet av "condition monitoring" eller tillståndskontroll har ökat. Den nya "marknaden" har medfört en annan typ av aktörer, som till skillnad mot de traditionella kraftbolagen, inte har samma kultur beträffande teknikorganisation. Därför har behovet av övervakningssystem ökat markant. Avhandlingen behandlar dessa ur ett teknisThe revenue from a power plant is strongly dependent on the life cycle cost. Today, when the market conditions for power-producing companies have shifted from a protected market to a deregulated market, the need for tools to monitor power plants has increased significantly. In this new competitive market, targeted revenues and operational economy drive the need for advanced monitoring tools. In th