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Phosphatidylethanol is formed by phospholipase D in animal cells exposed to ethanol. Previous reports have demonstrated that the degradation of phosphatidylethanol is slow, indicating that this lipid may be present in the cells after ethanol itself has disappeared. Accumulation of an abnormal alcohol metabolite may influence cellular functions. In the present study, cultivation of NG108-15 neurobl
This paper discusses two feasibility studies of Genetic Programming (GP) to the field of control theory, GP being a method inspired from nature where the goal is to create a computer program automatically from high-level statements of problems' requirements. The first feasibility study derives from stability theory and deals with evolving a program that can solve discrete-time Lyapunov equations.
The objective of this research that has taken me halfway to my PhD degree was to understand how HCCI combustion behaves in a small volume at high rotational speed. The investigation has been carried out using a modified model airplane engine. The whole study can be divided into two main parts; in the first, the nature of the glow plug combustion was investigated through experiments on a metal engi
This thesis covers the development of a silicon neural interface, with focus on silicon sieve electrode fabrication, design, nerve regeneration, signal recording and biocompatibility. A study of how the via hole size and transparency of the perforated sieve membrane influences the nerve regeneration is presented together with a study on soft tissue responses to planar and porous silicon. A method
The present article is based on the premise that mind is an emergent property of the processes that produce consciousness. Any scientific understanding must necessarily consider the need of an explanation of consciousness. Instead, the non-sense property of traditional scientific modelling appears to hide the phenomenon. In contrast, the explored hypothesis is based on the assumption that the mean
Popular Abstract in Swedish Denna avhandling presenterar en bred och kritisk översikt av litteraturen och forskningen angående inlärning av uttal och språkljud. De problem som framför allt vuxna har med att lära sig uttalet i ett främmande språk diskuteras och de olika hypotesen granskas. Jag argumenterar att inlärning är i stort sett en härmningsprocess. Två modeller av inlärning presenteras. DThis work is concerned with the acquisition of the phonetic characteristics of languages and dialects, and with the issue of learner talent or individual achievement in learning second languages. Following a survey of the literature on language learning limits, it is argued that the concentration on group trends in most of the existing literature, whilst convenient, serves more to obscure the reas
Urinary tract infections (UTIs) are clustered in certain individuals but the molecular basis of disease susceptibility is not known. A single gene was shown to control the susceptibility to acute pyelonephritis and renal scarring in mice. The IL-8 receptor homologue (mIL-8Rh) controls neutrophil function during acute infection and the mIL-8Rh deletion causes tissue damage through neutrophil entrap
Objective. When treatments with the potential to change the natural history of a disease are introduced, their longer-term effect on costs and quality of life (utility) has to be estimated using economic models. However, to remain useful tools, models must be updated when new information becomes available. Our earlier models in rheumatoid arthritis (RA) have been based on functional status, but it
The concentration of soluble HLA class I (sHLA-I) was measured by ELISA in serum samples from 30 well-characterised SLE patients at high and low disease activity states and from 100 healthy controls. HLA-A allotypes in the patients were analysed by a PCR-based typing technique. A higher level of sHLA-I was found in SLE patient sera both at high and low disease activity than in controls (P< 0.001).
Writers typically spend a certain proportion of time looking back over the text that they have written. This is likely to serve a number of different functions, which are currently poorly understood. In this article, we present two systems, ScriptLog+ TimeLine and EyeWrite, that adopt different and complementary approaches to exploring this activity by collecting and analyzing combined eye movemen
Physiotherapists are facing complex health challenges in the treatment of persons suffering from long-lasting musculoskeletal disorders and mental health problems. Basic Body Awareness Therapy (BBAT) is a physiotherapy approach within the movement awareness domain developed to bridge physical, mental, and relational health challenges. The purpose of this study was to reach a consensus on core phen
Background: Both lifestyle and genetic predisposition determine the development of type 2 diabetes (T2D), and studies have indicated interactions between specific dietary components and individual genetic variants. However, it is unclear whether the importance of overall dietary habits, including T2D-related food intakes, differs depending on genetic predisposition to T2D. We examined interaction
We discuss recent and on-going experiments, where molecular frame photoelectron angular distributions (MFPADs) of high kinetic energy photoelectrons are measured in order to determine the time evolution of molecular structures in the course of a photochemical event. These experiments include, on the one hand, measurements where single XUV/X-ray photons, obtained from a free electron laser (FEL) or
Background: The Tau PET ligand 18F-AV1451 has been shown to reliably detect paired helical filaments of tau in Alzheimer's disease, but it is not yet known whether it binds to the tau aggregates present in patients with mutations in the gene (MAPT) coding for the tau protein. Further, no study has yet compared the cerebral retention of 18F -AV1451 with the tau aggregates revealed using neuropathol
The aim of this study is to explore the possibility of identifying speaker stance in discourse, provide an analytical resource for it and an evaluation of the level of agreement across speakers in the area of stance-taking in discourse. We explore to what extent language users agree about what kind of stances are expressed in natural language use or whether their interpretations diverge. In order
The doctoral thesis seeks to discuss the transition between Viking Age and early medieval settlement and the establishment of the historical villages, based on archaeological material collected in Halland. The development is described in terms of three general periods of change: Period 1, c. 800–1000, consisting of farms with three-aisled longhouses. Period 2, c. 1000–1150, a transitional period w
Softwood bark contains a large amounts of extractives—i.e., soluble lipophilic (such as resin acids) and hydrophilic components (phenolic compounds, stilbenes). The effects of the partial removal of water-soluble extractives before acid-catalyzed steam pretreatment on enzymatic digestibility were assessed for two softwood barks—Norway spruce and Scots pine. A simple hot water extraction step remov
The Just-in-Time production system, or lean production system, tries to achieve a continuous flow of production, thereby reducing the inventories of materials, works-in- process and finished products. As a result only minimum levels of inventories exist in the various layers of the supply chain. Under this situation, the major earthquake followed by the tsunami on March 11, 2011 in Eastern Japan,
BACKGROUND: A great deal of interest has been focused on finding substitutes for autogenous bone grafts. Among the most interesting materials are different calcium phosphate compositions (e.g., hydroxyapatite [HA]), due to their biocompatible properties in hard and soft tissue.PURPOSE: The bone response to porous ceramic HA granules in combination with two lipid and one polysaccharide carrier was
