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Lund OsteoArthritis Division - From molecule to clinical implementation

Artros är vår vanligaste ledsjukdom och kännetecknas av att brosket i leden successivt bryts ned i kombination med funktionsnedsättning samt rörelse- och belastningssmärta. Processen är långsam; brosknedbrytning pågår under flera år utan påtagliga symptom. Först långt fram i processen syns röntgenologiska förändringar. Enligt evidensbaserade riktlinjer är den primära behandlingen fysioterapi och iOsteoarthritis (OA) is the most frequently occurring joint disease and is characterized by a gradual degradation of joint cartilage as well as pain and loss of function. The disease progression is slow; degradation of cartilage occurs for several years prior to symptoms. Radiological changes occur much later in the process. According to current evidence-based guidelines, the primary treatment is p

Functional C1-inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations

Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The most widespread underlying genetic deficiency is a heterozygous deficiency of the serine protease inhibitor Cl esterase inhibitor (C1-Inh). In addition to low C4 levels, the most important laboratory parameter for correct diagnosis of HAE or angioedema du

Lagring och omvandling av energi

Sustainable energy storage and conversion utforskar innovativa metoder för att effektivt lagra och omvandla energi från olika förnybara källor. Fokus ligger på teknik som avancerade batterier, vätgasproduktion, bränsleceller och termokemiska system samt säkerhetsaspekter på batterilagringssystem. Forskningen syftar till att öka energitätheten, minska kostnaderna och förbättra skalbarheten, vilket

https://www.energy.lth.se/sv/forskning/lagring-och-omvandling-av-energi - 2026-04-21

Tolerance induction with T cell-dependent protein antigens induces regulatory sialylated IgGs

Background: Under inflammatory conditions, T cell-dependent (TD) protein antigens induce proinflammatory T-and B-cell responses. In contrast, tolerance induction by TD antigens without costimulation triggers the development of regulatory T cells. Under both conditions, IgG antibodies are generated, but whether they have different immunoregulatory functions remains elusive. Objective: It was shown

The Role of Small-Bowel Capsule Endoscopy in the Diagnostic Algorithm of Complicated Perianal Disease

Introduction: Complicated perianal disease (cPD) may be the sole presentation of Crohn’s disease (CD). The role of small-bowel capsule endoscopy (SBCE) in the diagnostic algorithm of cPD is unclear. We aimed to evaluate the role of SBCE as a diagnostic tool, in patients with cPD, after a negative standard workup for CD. Methods: A multicenter, retrospective, cross-sectional study, in patients with

Effect of Pramipexole on Nucleus Accumbens Resting State Functional Connectivity in Anhedonia – an fMRI Study

Anhedoni, minskad motivation att uppleva lust, är associerad med förändringar i belöningssystemet. Belägen i ventrala striatum utgör den bilaterala nucleus accumbens (NAcc) den centrala noden i detta nätverk, där dopamin agerar som huvudsaklig excitatorisk neurotransmitter. Studier med funktionell magnetresonanstomografi (fMRI) har visat att aktiviteten i ventrala striatum minskar under belöningsbAnhedonia, reduced motivation to experience pleasure, is associated with alterations in the circuitry of the reward system. Located in the ventral striatum, the bilateral nucleus accumbens (NAcc) is the central hub of this network where dopamine acts as the main excitatory neurotransmitter. Studies using functional magnetic resonance imaging (fMRI) found that activity in the ventral striatum is de