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Background. In metastatic colorectal cancer, mutation testing for KRAS exon 2 is widely implemented to select patients with wild-type tumors for treatment with the monocloncal anti-EGFR antibodies cetuximab and panitumumab. The added predictive value of additional biomarkers in the RAS-RAF-MAPK and PI3K-AKT-mTOR pathways in colorectal cancer is uncertain, which led us to systematically review the

The key role of tropical forest belowground carbon stocks and fluxes is well recognised as one of the main components of the terrestrial ecosystem carbon cycle. This study presents the first detailed investigation of spatial and temporal patterns of fine root stocks and fluxes in tropical forests along an elevational gradient, ranging from the Peruvian Andes (3020 m) to lowland Amazonia (194 m), w

The ever increasing data rates in wireless communication require analog to digital converters (ADCs) with greater requirements on speed and accuracy, while being power efficient to prolong battery life. This dissertation contains an introduction to the field and five papers that focus on the continuous-time (CT) Delta-Sigma modulator (DSM) as ADC. Paper I analyses the performance degradation of d

The standardization of work processes is a common feature of the public administration, aiming at both efficiency and equal treatment of citizens. Combining this standardization with employee motivation is considered a challenge. This challenge is explored, based on a survey to 261 social insurance officers (SIOs) at the Swedish Social Insurance Agency. Results reveal that, contrary to expectation

During the last twenty years archaeology has experienced a technological revolution that spans scientific achieve-ments and day-to-day practices. The tools and methods from this digital change have also strongly impacted archaeology. Image-based 3D modeling is becoming more common when documenting archaeological features but is still not implement-ed as standard in field excavation projects. When

Background About 30% of cases of chronic lymphocytic leukaemia (CLL) carry quasi-identical B-cell receptor immunoglobulins and can be assigned to distinct stereotyped subsets. Although preliminary evidence suggests that B-cell receptor immunoglobulin stereotypy is relevant from a clinical viewpoint, this aspect has never been explored in a systematic manner or in a cohort of adequate size that wou

Cellulose can be chemically modified to produce derivatives with specific properties. Knowledge of correlations between the modification reaction, substituent distribution, origin of cellulose and properties are importaint in order to design processess so as to produce derivatives with the desired properties. This thesis describes research on newly developed analytical methods for the analysis of

ICA - instrumentation, control and automation - is a hidden technology. It is ubiquitous in all industrial processes, including water and wastewater treatment systems. Still, as long as everything works fine, it is not noted but when things go wrong it will be observed. ICA has now about forty years of history in water and wastewater systems and is well recognized. One early attitude was that ICA

Global Merger and Acquisition activity reached record levels in 2006, with the US and EU playing a large role in this activity. This paper examines the duties of a board which is subject to a takeover bid and any defensive moves the board may take to protect its company from acquisition. The US law in this field requires the boards to actively participate in any bid offers and grants these boards

Authors: Karin Lindsjö and Johanna Rydiander Title: Leadership in social work: A study of requested variables regarded middle level leaders during recruitment [translated title] Supervisor: Kristina Göransson Assessor: Staffan Blomberg Although working as a leader at middle level within social work is an interesting research area with its complex nature, there is not much science regarding this f

Abstract Title: Total Cost of Ownership – Revealing the true cost of owning and operating equipment. Authors: Anna Bladh Anna Ström Tutors: Michaela Boye, Parts and Service, PTD, Alfa Laval Göran Berg, Parts and Service, PTD, Alfa Laval Charlotta Johnsson, Department of Automatic Control, LTH, Lund University Bertil I. Nilsson, Department of Industrial Management and Logistics, LTH, Lund Universit

Den 8 november 2011 gav den danska Sjö- och Handelsrätten en dom i Rolex III som resulterade i en del osäkerhet angående det rättsliga klimatet kring intellektuella rättigheter, i synnerhet angående privata importer av varor som gör intrång i sådana rättigheter. Avgörandet i Rolex III är kontroversiellt eftersom det förlitar sig på användandet av en legal fiction på ett sådant sätt att avgörandetsOn November 8th 2011 the Danish Maritime and Commercial Court pronounced a ruling on the Rolex III case which caused uncertainty regarding the legal climate of intellectual property law, specifically the importation of infringing goods for private use. As the Rolex III case is quite a controversial ruling, relying on the use of legal fiction in such a way that its legal validity is questionable, i

Dividend is a much-debated subject and has been compared to a puzzle with no sole solution to explain why firms pay dividend. Many academics have tried to determine what company variables determines a firm’s dividend policy. These studies have provided different explanatory variables to explain why firms pay dividends. Therefore, the main purpose of this study was to fill in a piece of the dividen

BACKGROUND: Shared decision-making (SDM) between clinicians and patients is one of the pillars of the modern patient-centric philosophy of care. This study aims to explore SDM in the discipline of trauma and emergency surgery, investigating its interpretation as well as the barriers and facilitators for its implementation among surgeons.METHODS: Grounding on the literature on the topics of the und

We present predictions for the SM-Higgs-pair production channels of relevance at the LHC: gluon-gluon fusion, VBF, and top-pair, W, Z and single-top associated production. All these results are at the NLO accuracy in QCD, and matched to parton showers by means of the MC@NLO method; hence, they are fully differential. With the exception of the gluon-gluon fusion process, for which a special treatme

This study is about Wikipedia which defines itself as a free online encyclopaedia. Our chief interest lies in the debate and the controversy which has arisen around Wikipedia. After reading critical articles concerning Wikipedia we found that the debate for most parts had one identifiable theme namely the question whether Wikipedia is an encyclo-paedia or not. Encyclopaedia as a term and a phenom

Problem Definition: Ericsson wants to increase their focus on reducing the total cost of packaging for the company in the whole world. They want to create a simple calculation model that can calculate the total packaging cost and compare different packaging solutions (country, freight, packaging, and product) in order to find the most cost effective packaging solution. This will facilitate the dev

The most common preventive and treatment service for children in child welfare services in Sweden is the contact family program. The number of children who are involved in the program has steadily increased. Usually it is a single mother who apply for or is offered this service. The aim with a contact family is that the parent should get respite and that the child should have its network enlarged