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Mechanisms controlling striatal projection neurone generation, from patterning to early differentiation

Popular Abstract in Swedish Detta arbete handlar om utvecklingsneurobiologi. Ett långt ord men så beskriver det också precis vad det rör sig om: biologiska studier rörande nervsystemets utveckling. Generellt sett kan man säga att utvecklings-neurobiologisk forskning på lång sikt syftar till att förstå nervsystemets utveckling såpass väl att man skall kunna använda denna kunskap för att reparera etThe striatum is part of the telencephalon, the most anterior part of the vertebrate brain. From when it first can be identified, telencephalic morphology is highly complex and a wide range of mechanisms has been suggested to participate in its induction, patterning and neurogenesis. Sonic hedgehog (shh), a gene coding for a secreted protein has been suggested to be required for ventral telencephal

Public participation and written submissions.: A transport infrastructure planning case study

Written submissions or comments as a response on an EIS (Environmental Impact Statement) rank as one of the most common forms of public participation. Within public participation research there appears to be an international dearth of knowledge concerning such written submissions. The possible impact of such responses on an EIS is - with few exceptions - seldom put in focus. The aim in the present

Microarrays based on affinity-tagged single-chain Fv antibodies: Sensitive detection of analyte in complex proteomes

Protein-based microarrays are among the novel class of rapidly emerging proteomic technologies that will allow us to efficiently perform global proteome analysis. However, the process of designing adequate protein microarrays is a major inherent problem. In this study, we have evaluated a protein microarray platform based on nonpurified affinity-tagged single-chain (sc) Fv antibody fragments to ge

Screening Detected Celiac Disease in Children

Popular Abstract in Swedish Bakgrund och syfte med avhandlingen Glutenintolerans, celiaki är en av de vanligaste kroniska sjukdomarna bland barn och innebär att man inte tåler gluten, som är ett protein och finns i vete, råg och korn. Tunntarmen har en veckad slemhinna med fingerlika utskott , tarmludd och hela tarmen har en yta på 250 kvadratmeter, vilket är lika stort som en tennisplan. Den stBackground: The prevalence of celiac disease (CD) is estimated to be around 1%, but most CD cases are undiagnosed. Sweden experienced an epidemic of clinically detected celiac disease in children younger than 2 years of age, partly due to changes in infant feeding practices, were the amount of gluten and age at introduction was changed. However, it was not clear if the increase in clinically detec

Simultaneous saccharification and co-fermentation for bioethanol production using corncobs at lab, PDU and demo scales

Background: While simultaneous saccharification and co-fermentation (SSCF) is considered to be a promising process for bioconversion of lignocellulosic materials to ethanol, there are still relatively little demo-plant data and operating experiences reported in the literature. In the current work, we designed a SSCF process and scaled up from lab to demo scale reaching 4% (w/v) ethanol using xylos

Transition probabilities of astrophysical interest in the niobium ions Nb+ and Nb2+

Aims. We attempt to derive accurate transition probabilities for astrophysically interesting spectral lines of Nb II and Nb III and determine the niobium abundance in the Sun and metal-poor stars rich in neutron-capture elements. Methods. We used the time-resolved laser-induced fluorescence technique to measure radiative lifetimes in Nb II. Branching fractions were measured from spectra recorded u

Bacterial abundance, production and organic carbon limitation in the Southern Ocean (39-62 degrees S, 4-14 degrees E) during the austral summer 1997/1998

Bacterial abundance and production were studied in different zones in the Southern Ocean (39-62degreesS, 4-14degreesE) during a cruise in December-January 1997/1998. The role of potential growth limitation of bacteria due to limited availability of organic carbon (glucose) or inorganic N and P was studied in parallel. A positive correlation between surface water temperatures (-2 to 18 degreesC) an

Legislating a Woman's Seat on the Board: Institutional Factors Driving Gender Quotas for Boards of Directors

Ten countries have established quotas for female representation on publicly traded corporate and/or state-owned enterprise boards of directors, ranging from 33 to 50 %, with various sanctions. Fifteen other countries have introduced non-binding gender quotas in their corporate governance codes enforcing a "comply or explain" principle. Countless other countries' leaders and policy groups are in th

Protein kinase mediated upregulation of endothelin A, endothelin B and 5-hydroxytryptamine 1B/1D receptors during organ culture in rat basilar artery.

1 Organ culture has been shown to upregulate both endothelin (ET) and 5-hydroxytryptamine 1B/1D (5-HT(1B/1D)) receptors in rat cerebral arteries. The purpose of the present study was to investigate the involvement of protein kinases, especially protein kinases C (PKC) and A (PKA) in this process. 2 The effect of inhibiting protein kinases during organ culture with staurosporine (unspecific protein

The Department of English in Lund : Working Papers in Linguistics Vol. 3

The Department of English in Lund: Working Papers in Linguistics is an annual volume produced by the English Department at Lund University in Sweden. Its main aim is to publicize research being carried out by staff and post-graduate students in the department, but we are also pleased to include contributions from members of neighbouring departments and universities. The contributions in volume 3

Cardiovascular responses to intravenous calcitonin gene-related peptide (CGRP) in the albino rabbit

The regional sensitivity of different vascular beds to i.v. CGRP was investigated in the albino rabbit by using the microsphere method. Experiments were performed without pre-treatment on both conscious and pentobarbital-anaesthetized animals. In addition, in one series on conscious animals, rabbits were pre-treated with indomethacin in order to reduce the formation of prostaglandins. In another s

Demokratiska genvägar : Expertinflytande i den svenska lagstiftningsprocessen om medicinsk genteknik

Popular Abstract in Swedish Denna avhandling handlar om expertinflytande och demokrati och fokuserar hur politiskt beslutsfattande i frågor med stort beroende av vetenskaplig expertis bör gå till för att vara demokratiskt. Studiens övergripande syfte är att från ett demokratiskt perspektiv värdera den svenska lagstiftningsprocessen om medicinsk genteknik, som kan ses som ett fall av beslutsfattand

Chromoendoscopy with particular reference to a modified endoscopic Congo red test

Popular Abstract in Swedish Modern gastroenterologi är till stora delar helt beroende av resultat från gastrointestinal endoskopi och många av de sjukdomar som hänförs till denna specialitet kan också behandlas med modern endoskopisk och minimal invasiv teknik. Gastroskopi är förstahandsundersökning av patienter med såväl kroniska som akuta symptom från övre gastrointestinalkanalen. Den gastroskopChromoendoscopy, endoscopic tissue staining, is an adjunctive method using chemical agents applied to the mucosal surface in order to aid gastrointestinal endoscopic diagnosis and therapy. Acid producing mucosa in the GI tract may be visualized endoscopically by Congo red staining in combination with stimulation of gastric acid production. Congo red is a reactive indicator dye that changes color f

Measuring change in a sector - CREDIT Case SE06

This case describes an ongoing initiative in Sweden with the aim of measuring the development of the Swedish infrastructure sector. The reason this case was chose is that it is one, of only a very few, national initiatives with a clear aim of taking an holistic approach to assess the development of one large share of the Swedish construction sector. The purpose of this case is to investigate: – Wh

Effects of future climate on carbon assimilation of boreal Norway spruce

Popular Abstract in Swedish Det norra barrskogsbältet, även kallat de boreala skogarna, sträcker sig runt hela norra halvklotet. Det utgör en tredjedel av den globala skogsytan, och innehåller hälften av den totala mängden kol finns lagrat i samtliga skogsekosystem. Trots de låga temperaturerna, den korta vegetationssäsongen och en liten mängd inkommande solenergi under året, är dessa ekosystem viIn boreal forests, the main factors limiting biomass production are the harsh climate, which combines a short growing season and low annual levels of incoming solar energy, and the limited availability of nitrogen. These limitations will be directly affected by climate change, and may in turn substantially affect the carbon budget of the boreal forests, the production of wood and biofuel, biodiver

Health Claims in the EU and their Scientific Substantiation

A new Regulation on nutrition and health claims came into force in 2007 with implementation during a three-year period and will harmonise this area within the European Community. It makes provision for health claims on foods, including reduction of disease risk claims, and thus recognises the importance of food and nutrition for health. Member states have provided suggestions for claims regarding

Environmental concern, self-concept and defence style. A study of the Agenda 21 process in a Swedish municipality

The experience of working with Agenda 21 was investigated among child care personnel in a small Swedish municipality. The main aim was to study the correlation between environmental concern and personality. It was hypothesised that people caring about the environment would have a positive self-concept and use an adaptive defence style. The result showed that personal concern ( r =0.42, p =0.000),

Electrophysiological evaluation and visual outcome in patients with central retinal vein occlusion, primary open-angle glaucoma and neovascular glaucoma.

Purpose: To evaluate patients with central retinal vein occlusion (CRVO) and neovascular glaucoma (NVG) using electrophysiology in order to gain better understanding of visual outcome and risk factors, such as previously diagnosed primary open-angle glaucoma (POAG). Methods: Eighty-three patients (83 eyes) initially presenting with CRVO and examined with full-field electroretinography (ERG) within

N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis

A peptide derived from the N-terminus of the unprocessed bovine prion protein (bPrPp), incorporating the hydrophobic signal sequence (residues 1-24) and a basic domain (KKRPKP, residues 25-30), internalizes into mammalian cells, even when coupled to a sizeable cargo, and therefore functions as a cell-penetrating peptide (CPP). Confocal microscopy and co-localization studies indicate that the inter