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alpha(1)-Microglobulin is a 26-kd protein, widespread in plasma and tissues and well-conserved among vertebrates. alpha(1)-Microglobulin belongs to the lipocalins, a protein superfamily with highly conserved 3-dimensional structures, forming an internal ligand binding pocket. The protein, isolated from urine, has a heterogeneous yellow-brown chromophore bound covalently to amino acid side groups a
We relate variation in the timing of arrival by migrating birds breeding at northerly latitudes to individual differences in the prior accumulation of energy stores. Balancing starvation risks early in the season against the almost universal declining trend in reproductive prospects with advancing date is seen as an individual decision with fitness consequences. We review three studies implicating
A dream of many pharmaceutical companies is to be able to register a large design space with the regulatory agencies. The problem is that this will require both time and money, so an intelligent method of validating a design space is needed. The design space should only cover operating points at which the process runs optimally. This means that the process should be optimized for different process
Popular Abstract in Swedish Hawaiianernas liv och historia har dokumenterats allt sedan första kontakten med västerländska äventyrsresanden i slutet av 1700-talet. I samband med amerikanska missionärers ankomst år 1820 introducerade och etablerade dessa missionärer en puritansk lära och kunskapsförmedling via det skrivna ordet. Mötena mellan de olika kulturerna har beskrivits som fredliga. Dock haThe life and history of the Hawaiians has been documented ever since the contact with Western adventurers at the end of the 18th century. In connection with the arrival of American missionaries in 1820, these missionaries introduced and established a puritanical doctrine and method of communicating knowledge by way of the written word. The encounters between the different cultures have been descri
There is now considerable evidence for the involvement of K+ channels in nitric oxide (NO) induced relaxation of smooth muscles including the myometrium. In order to assess whether apamin-sensitive K+ channels play a role in NO - induced relaxation of the human uterus, we have studied the effect of specific blockers of these channels on the relaxation of myometrium from non-pregnant women. In vitr
Minute electronic (bio) devices will likely play an increasingly important role in everyday life and beyond, as overall device size often limits device functionality and applicability, a factor especially critical for brain implants. Recent progress in micro-and nanoelectronics has enabled the production of nanoscale electronic components; however, overall device size is often defined by technical
Abstract Aim: The aim of this study was to explore experiences of mobility device (MD) use among very old single-living Swedish men. Methods: A multiple case study of three men, involving quantitative and qualitative data, was used in an embedded mixed methods design and presented in three narrative stories. To capture differences and similarities in the use of MDs a cross-case analysis was conduc
Brain-machine interfaces (BMIs) provide a uni- or bidirectional communication link between the central nervous system and the outside world. This link facilitates the studying of neuronal mechanisms underlying behavior as well as the treatment of neurological disease. Wired BMIs are limited in the sense that they restrict the mobility of the subject and they increase the risks for post-surgical co
A cochlear implant (CI) is a device that provides individuals with severe to profound hearing impairment (SPHI) with auditory stimulation, which makes it possible for them to develop skills related to spoken communication. We have little knowledge about how hearing with a CI influences cognitive and communicative development and there is a need for development of methods for assessment. The genera
The refugee status determination procedure involves complex issues of both law and fact. The process becomes even more complicated when facts arise that give indications on the possible applicability of article 1.F of the Refugee Convention. In this case the decision-maker has to decide on the one hand if the applicant qualifies for refugee status and on the other hand if there are serious reasons
Parterna till en företagskoncentration måste ofta ändra den planerade transaktionen för att kommissionen anser att den påtagligt skulle hämma den effektiva konkurrensen inom gemenskapen. Kommissionen ser helst att de berörda företagen erbjuder sig att avyttra en verksamhet för att på så vis på ett permanent sätt upprätthålla eller återställa konkurrensen på marknaden. Denna typ av strukturellt korParties to a merger often need to change their original transaction plan because the commission’s investigation shows that the merger would lead to significant impediments of the effective competition on the common market. The Commission prefers the undertakings to divest such businesses or assets necessary to permanently maintain or restore an effective competition on the common market. However,
The duty of utmost good faith in the marine insurance contract law and the duty of good faith in the general contract law are quite similar in nature. Former recognises that the parties must make true representation and must disclose all material information while latter recognises the duty of representation only and does not at all recognise the duty of disclosure. The parties in the marine insu
Individer som avslöjar misstankar om eller föreliggande brott, risker eller missförhållanden inom arbetsplatser kallas för whistleblowers. Företeelsen begränsas inte till en viss utövarkrets utan kan utövas av envar. Whistleblowing är värdefullt för svensk företagsamhet samt samhället i stort eftersom allvarliga brott, risker och andra olägenheter upptäcks och kan avhjälpas. Men whistleblowers uppIn this thesis the current Swedish legislation concerning whistle-blowers is examined. The thesis has two main purposes: to clarify under which circumstances a whistle-blower can make a disclosure about wrongdoings and to examine and analyse the protection of whistle-blowers in the Swedish law. Whistleblowing refers to the action of individuals who make a public disclosure about illegal, immoral o
CELSIUS Heavy-Ion Collision Silicon detector system (CHICSi) is a large solid angle, barrel-shaped detector system, housing up to 600 detector telescopes arranged in rotational symmetry around the beam axis. CHICSi measures charged particles and fragments from nuclear reactions. It operates at internal targets of storage rings. In order to optimize space and momentum-space coverage and minimize th
The major aim of this study was to investigate the CYP3A4 metabolism and polarized transport of ropivacaine and its metabolite 2',6'-pipecoloxylidide (PPX) in tissue specimens from the human small and large intestine. Ropivacaine has been shown to be effective in the treatment of ulcerative colitis in human colon. This study was conducted using a modified Ussing-chamber technique with specimens fr
This study was undertaken in order to compare regional cerebral blood now (rCBF) and EEG findings of patients with clinically diagnosed dementia with Lewy bodies (clinDLB) and Alzheimer’s disease (clinAD). Furthermore, within the clinDLB group to compare cases with and without neuropathologically verified Lewy bodies (LBs). When we studied 200 dementia cases in a prospective longitudinal dementia
BACKGROUND & AIMS: Evaluation of the small intestine for inflammation has traditionally relied on small-bowel follow-through (SBFT), but multiple studies have demonstrated its low diagnostic accuracy. Capsule endoscopy (CE) transmits high-quality images of the small intestinal mucosa; it can be used to visualize the entire length of the small bowel and much of the mucosa. We compared the diagn
The acoustic cavitation phenomenon is a source of energy for a wide range of applications such as sonoluminescence and sonochemistry. The behavior of a single bubble in liquids is an essential study for acoustic cavitation. The bubbles react with the pressure forces in liquids and reveal their full potential when periodically driven by acoustic waves. As a result of extreme compression of the bubb
The creation of Region Skåne, and the transfer of the development responsibility from the national administrative country board (Länsstyrelsen) has given the state new challenges. New structures have grown between Region and State, and also between different municipalities. These can be characterized as Policy-networks, and the goal of this study is to analyze the planning process of the regional
