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Purpose: In addition to genomic signaling, it is accepted that estrogen receptor-alpha (ER alpha) has nonnuclear signaling functions, which correlate with tamoxifen resistance in preclinical models. However, evidence for cytoplasmic ER localization in human breast tumors is less established. We sought to determine the presence and implications of nonnuclear ER in clinical specimens. Experimental D
Background: We have previously identified a locus on human chromosome 20q13.1, encompassing related genes of postulated WFDC-type protease inhibitors and semen coagulum proteins. Three of the genes with WFDC motif also coded for the Kunitz-type protease inhibitor motif. In this report, we have reinvestigated the locus for homologous genes encoding Kunitz motif only. The identified genes have been
The genetic causes of familial breast cancer are still unclear, where only less than 20% have evident germline mutations. Most studies focus on mutations that cause a direct impact in the protein, disregarding the synonymous variants, where the codon is changed but the amino acid encoded remains the same. Synonymous variants can affect mRNA stability and translation, by differences in codon usage
Objectives: To investigate absolute and relative risk of serious infections in adult/elderly inflammatory bowel disease (IBD) diagnosed 2002–2017. Methods: Nationwide, register-based cohort study of Swedish patients with IBD compared with general population matched reference individuals with regard to time to first serious infection, equal to hospital admission. Multivariable Cox regression estima
PURPOSEAPR-246 (PRIMA-1MET) is a novel drug that restores transcriptional activity of unfolded wild-type or mutant p53. The main aims of this first-in-human trial were to determine maximum-tolerated dose (MTD), safety, dose-limiting toxicities (DLTs), and pharmacokinetics (PK) of APR-246. PATIENTS AND METHODSAPR-246 was administered as a 2-hour intravenous infusion once per day for 4 consecutive d
Background Medication abortion, with a combination of mifepristone and misoprostol, is highly effective and safe. However, there is insufficient evidence on efficacy and safety at very early gestations before a pregnancy can be visualized with ultrasonography. Methods We conducted a multicenter, noninferiority, randomized, controlled trial involving women requesting medication abortion at up to 42
Mitochondrial dysfunction is associated with pathogenic mitochondrial (mt)DNA mutations. The majority of mtDNA point mutations have a heteroplasmic status, which is defined as the coexistence of wild-type and mutated DNA within a cell or tissue. Previous findings demonstrated that certain mtDNA heteroplasmic mutations contribute to widely spread chronic diseases, including cancer, and alterations
Global biodiversity loss threatens ecological stability and human well-being. Biodiversity credits(biocredits) have emerged to address the funding gap for conservation, but may overlook local values and uses of nature, which are vital for sustaining cultural identities, livelihoods, and long-term stewardship of ecosystems. This thesis, grounded in the Plural Valuation of Nature framework, explores
Agenda 2030 Graduate School monthly newsletter #6 2025-06-09 Ylva van Meeningen Hi! I do not know about you, but I am SO ready for summer and to not check my e-mails for weeks on end. It was pointed out to me recently that working within in academia is hard. Of course most of us know that, I know that. But this person compared it to their line of work and how the insane tempo that we have would no
Third term info for S depts 1 GRADUATE SCHOOL THIRD TERM INFORMATION THIRD TERM OPTIONS Courses February 2022 AUTUMN 2022 This is an extract from Graduate School’s information about third term studies. It provides an overview of stand-alone courses that will be open for application ahead of the autumn 2022 term. 2 ELECTIVE COURSES What are electives? Electives are courses of your own choice that w
https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2022-02/Third_term_handbook_Autumn_2022.pdf - 2026-07-08
314490_nr1_OMSL_RRSW_2021_5.indd RESEARCH REPORTS IN SOCIAL WORK 2021:5 School of Social Work | Lund University Hur har andrahandslägenheter i Malmö kommun fördelats till hemlösa över tid? En studie av prioriteringar och exkluderingar WEDDIG RUNQUIST SOCIALHÖGSKOLAN | LUNDS UNIVERSITET LUNDS UNIVERSITET Socialhögskolan ISBN 978-91-7895-539-8 www.soch.lu.se 9 7 8 9 1 7 8 9 5 5 3 9 8 Sv an en m är k
https://www.soch.lu.se/sites/soch.lu.se/files/2021-10/Web%20RRSW%202021_5-X.pdf - 2026-07-08
120 credits The programme is offered for the last time autumn 2022. The programme focusses on areas that play a central role in pharmaceutical and biotechnological development. You will take courses in pharmacology, immunology and infection biology, during which theory is integrated with training of laboratory skills. You will also achieve insights into the drug development process, from research
Kursguide - Course Syllabus • • • • • • Fastställande Kursplanen är fastställd av Institutionsstyrelsen vid Teaterhögskolan i Malmö 2018-12- 12 att gälla från och med 2019-01-21, vårterminen 2019. Allmänna uppgifter Kursen ges som en fristående kurs. Undervisningsspråk: Svenska och engelska Därtill kan andra skandinaviska språk förekomma. Kursens mål Studenten ska Kunskap och förståelse uppvisa
https://www.thm.lu.se/sites/thm.lu.se/files/skab14_platsspecifika_moten.pdf - 2026-07-08
Calculation - estimating the costs of a project Guidance 9/11/24 Guidance "Full cost estimate for funding application" is to be enclosed with the application. It is not compulsory to use this calculation, which is intended to provide support in estimating the costs of a project. General information about the calculation - The formulas in the calculation are not protected. - The starting year can b
https://www.cec.lu.se/sites/cec.lu.se/files/2025-01/Calculation%20for%20external%20funding%202025%20eng%20CEC.xlsx - 2026-07-08
