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Popular Abstract in Swedish En halvledare är en kristall vars egenskaper till stor del bestäms av dess bandgap, som i någon mening kan ses som lägesenergin hos fria elektroner i kristallen. En kvantprick är en liten volym halvledarmaterial som är inbäddad i ett annat material med större bandgap. Det gör att volymen attraherar laddning eftersom elektroner (precis som allt annat) helst minimerar sinThis thesis presents spectroscopic studies of single self-assembled InP quantum dots (QDs). The electronic properties of these QDs have been studied by photoluminescence (PL) and scanning tunnelling luminescence (STL). The QDs were grown in the Stranski-Krastanow mode and were embedded in GaInP. This material is slightly n-type, giving a Fermi-level close to the conduction band edge at low temper

Background: Presence of circulating tumor cells (CTCs) is a validated prognostic marker in metastatic breast cancer. Additional prognostic information may be obtained by morphologic characterization of CTCs. We explored whether apoptotic CTCs, CTC clusters and leukocytes attached to CTCs are associated with breast cancer subtype and prognosis at base-line (BL) and in follow-up (FU) blood samples i

The PEFC has emerged as the most viable fuel cell type for automotive and some portable applications, and also has potential back-up power unit applications due to its low operating temperature, comparative simplicity of construction, high power density, and ease of operation. In spite of tremendous scientific advances, as well as engineering progress over the last few decades, the commercializati

Reprogramming of somatic cells into pluripotency stem cell state have opened new opportunities in cell replacement therapy and disease modeling in a number of neurological disorders. It still remains unknown, however, to what degree the grafted human induced pluripotent stem cells (hiPSCs) differentiate into a functional neuronal phenotype and if they integrate into the host circuitry. Here we pre

A model for evolution of cracks as a result of strain-assisted corrosion is presented. The considered cracks possess a realistic geometry, where the tip region is an integral part of the crack surface instead of being a singular point. This geometry is either implicitly defined or is a consequence of crack nucleation from surface irregularities. The evolution model poses a moving boundary value pr

Popular Abstract in Swedish Stärkelse är en miljövänlig och naturlig produkt som kan framställas ur växtriket. Stärkelse har många användningsområden inom livsmedelsindustrin såsom förtjockningsmedel och fettersättning men har även många icke livsmedelsindustriella användningsområden bl. a. i pappers-, kosmetika-, lim-, textil-, oljeborrning- och läkemedelsindustrin. Med kemiska, fysikaliska samt Starch is a plant-derived polysaccharide with many uses in different food and non-food applications. In this thesis, the production of two novel potato starch qualities, amylopectin and high-amylose, and the modifications and the characteristics of the produced plants and starches are described. The novel potato starch qualities will find uses in e.g. the paper, adhesive, textile and packing indus

Popular Abstract in Swedish Gränsvärden för NOX-utsläppen i avgaserna från tunga dieselmotorer kommer att minskas i den Europeiska Unionen från 3,5 g/kWh (Euro IV) idag till 2,0 g/kWh (Euro V) år 2008. I USA och Japan är trenden likadan och utveckling av ett avgassystem för tunga dieselfordon verkar oundviklig. I detta arbetet har en motorrigg byggts upp som bestod av en 11 l dieselmotor och ett aThe legislative limits for NOX emissions in the exhaust gas from heavy-duty diesel engines will be decreased in the European Union from today 3.5 g/kWh (Euro IV) to 2.0 g/kWh in 2008 (Euro V). In the USA and Japan a similar trend can be seen. Accordingly, the development of an exhaust aftertreatment system for heavy-duty trucks seems unavoidable. In this work, an 11 l diesel engine rig has been bu

Popular Abstract in Swedish Årligen diagnostiseras cirka 60 000 nya fall av cancer i Sverige (Socialstyrelsen, 2015), och var tredje person beräknas få en cancerdiagnos under sin livstid. Trots stora framsteg inom forskning och utveckling är cancer, näst efter hjärt- och kärlsjukdomar, den vanligaste dödsorsaken i vårt samhälle. Bland de tio vanligaste formerna av cancer hör lymfom, vilket är etMantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. The aim has been to identify novel targets with the potential to eradicate malignant cel

Background Analysis of the Swedish Farmacotherapy (Swefot) trial at 12 months showed that the addition of an anti-tumour-necrosis-factor agent gave an improved clinical outcome compared with the addition of conventional disease-modifying antirheumatic drugs in patients with methotrexate-refractory early rheumatoid arthritis. Here we report the 2 year follow-up assessment. Methods In this randomise

OBJECTIVE: The influence of the gastrointestinal (GI) microflora in patients with irritable bowel syndrome (IBS) has not been clearly elucidated. This study was undertaken to see if patients with IBS have an imbalance in their normal colonic flora, as some bacterial taxa are more prone to gas production than others. We also wanted to study whether the flora could be altered by exogenous supplement

Popular Abstract in Swedish Tekniken för vitreoretinal kirurgi har utvecklats betydligt de senaste åren, både vad gäller metodik och instrumentering. Allt fler sjukdomstillstånd i näthinnan kan nu behandlas. För att utveckla dessa metoder vidare, och även öka kunskapen bakom verkningsmekanismen för deras effektivitet, är standardiserade djurmodeller där både funktion och histologi kan utvärderas aThe field of vitreoretinal surgery has expanded greatly over the last decades. A continuous refinement of surgical methods and instruments has increased the number of treatable retinal disorders. Vitrectomy, retinectomy and laser treatment are all part of the modern surgical arsenal. In order to further develop and refine these methods, and also to improve the knowledge of the mechanisms behind th

Popular Abstract in Swedish Kritiskt sjuka patienter på intensivvårdsavdelningar (IVA) har ofta störningar i blodets levringsförmåga (koagulation). Kliniska tecken som blodpropp (djup ventrombos eller blodpropp i lungorna) och/eller blödning kan vara resultatet av aktivering och konsumtion av koagulationsfaktorer och koagulationshämmare. Disseminerad intravaskulär koagulation (DIC, som är en samtiCritically ill patients in intensive care units (ICU) often have coagulation disturbances. Clinical manifestations such as thromboembolism and/or bleeding may result from activation and consumption of coagulation factors and inhibitors. Disseminated intravascular coagulation (DIC) is a severe condition with an often-poor prognosis. Global haemostatic tests are inexpensive, widely available, and ma

Popular Abstract in Swedish Avregleringen av elmarknaden uppmuntrar kraftbolag och oberoende kraftproducenter till att driva sina kraftverksanläggningar på ett marknadsorienterat sätt. För att behålla de ekonomiska marginalerna på plussidan så har de mest populära åtgärderna varit att förbättra elverkningsgraden genom ändringar i hårdvaran samt höja totalverkningsgraden genom till exempel samproduThe deregulation of the electricity market drives utilities and independent power producers to operate heat and power plants as profit centers. In order to keep the economic margins on the credit side, the preferred measures have been to improve the electrical efficiency through changes in the hardware and boost the overall efficiency through e.g. combined heat and power (CHP) generation. The bett

The purpose of this dissertation is to study the concept of autism from a socio-legal perspective and to analyze the actual use of law in an area where knowledge rivalry is present, as in the case of autism. The ambition is to illustrate how law reacts to, and deals with, rivalry fields of knowledge within the system of decision-making. During the last decades, research on autism has been intense

Background, In adults, it has been shown that the pharmacokinetics of doxorubicin are highly variable, despite standardization of the dose based on body surface area (BSA). The purpose of this study was to determine the plasma concentrations of doxorubicin and its active metabolite doxorubicinol in children treated for acute lymphoblastic leukemia (ALL). Procedure. Children, 107 in number, aged 1.

Popular Abstract in Swedish Många åtminstone i min generation kommer säkert ihåg att de under gymnasiets biologilektioner fick lära sig att vatten diffunderade fritt över cellens membran ? osmos och fri diffusion var ledorden. Jag vet inte hur läroböckerna är utformade idag, men efter att Nobelpriset i kemi år 2003 tilldelades Peter Agre för upptäckten av att aquaporiner fungerar som vattenkanalerIn order to identify integral and peripheral proteins associated with the plasma membrane (PM), highly purified Arabidopsis PMs were analyzed by mass spectrometry. In total, 238 putative PM proteins were identified, of which 114 were predicted to have transmembrane domains or to be PM-anchored. Identified proteins were involved in transport, signal transduction, membrane trafficking and stress res

Popular Abstract in Swedish Ett material som utsätts för varierande last, även under gränslasten för statisk kollaps, riskerar att utveckla sprickor som i sin tur kan orsaka brott. Denna typ av materialnedbrytning kallas utmattning och är ett ständigt aktuellt forskningsområde. Väldigt korta sprickor är kända för att växa på ett sätt som avviker från hur längre utmattningssprickor beter sig, ävenThe growth of short fatigue cracks deviates from the behaviour of long fatigue cracks even if subjected to the same nominal driving force. The influence from the microstructure is pronounced, while crack closure effects may not be that important as for longer cracks. The objective of this thesis is to study the local conditions for crack growth for two different short crack problems, and to develo

Study Design. Multicenter randomized controlled trial.Objective. To compare the efficacy and safety of balloon kyphoplasty (BKP) to non-surgical management (NSM) over 24 months in patients with painful vertebral compression fractures (VCF).Summary of Background Data. Recently, several large randomized controlled trials have been conducted and reported how vertebral augmentation compares with NSM f

Popular Abstract in English Huntingtons sjukdom (HS), även kallad danssjukan, är en ärftlig och dödlig sjukdom som leder till ofrivilliga motoriska rörelser. Personer med HS får vanligtvis symtom i medelål- dern och avlider efter 15–20 år. Diagnosen ställs klinisk när de första ofrivilliga rörelserna uppträder. Dessa symtom kan kopplas till celldöd i de delar av hjärna som styr vår rörelse. SjukdoHuntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. The hypothalamus is an area in the brain involved in the regulation of emotions and m

Objective: Transcatheter valve-in-valve implantation has emerged as an option, in addition to reoperative surgical aortic valve replacement, to treat failed biologic heart valve substitutes. However, the clinical experience with this approach is still limited. We report the comprehensive experience of transcatheter valve-in-valve implantation in the Nordic countries from May 2008 to January 2012.