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Cancer mortality is exacerbated by late-stage diagnosis. Liquid biopsies based on genomic biomarkers can noninvasively diagnose cancers. However, validation studies have reported ~10% sensitivity to detect stage I cancer in a screening population and specific types, such as brain or genitourinary tumors, remain undetectable. We investigated urine and plasma free glycosaminoglycan profiles (GAGomes
The objective of this article was to assess the cost-effectiveness of screening strategies for cardiovascular diseases (CVD). A decision analytic model was constructed to estimate the costs and benefits of one-off screening strategies differentiated by screening age, sex and the threshold for initiating statin therapy (“uniform” or “age-adjusted”) from the Spanish NHS perspective. The age-adjusted
A tight control over AKT/PKB activation is essential for cells, and they realise this in part by regulating the phosphorylation of Ser473 in the "hydrophobic motif" of the AKT carboxy-terminal region. The RICTOR-mTOR complex (TORC2) is a major kinase for AKT Ser473 phosphorylation after stimulation by several growth factors, in a reaction proposed to require p21-activated kinase (PAK) as a scaffol
Agency theory describes the conflict of interest between the principal (stockholders) and the agent (CEO). Aligning the incentives of executives with those of the owners is the most direct way to mitigate the agency problem. If there is no meaningful link between CEO compensation and company performance, it is doubtful that the large sums of assets in public corporations are being managed efficien
Appraisal is assuredly one of the most important archival practices. The decision whether to preserve or destroy a collection of archival material, or parts thereof, has direct implications for multiple societal aspects, including the cultural heritage aspect, citizens’ ability to exercise their civil rights, and access to source material for legal and research purposes. Archival appraisal within
Our aim was to identify the best diagnostic test sequence for predicting Alzheimer's disease (AD)-type dementia in subjects with mild cognitive impairment (MCI) using cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) biomarkers. We selected 153 subjects with mild cognitive impairment from a multicenter memory clinic-based cohort. We tested the CSF beta amyloid (A beta)1-42/tau ratio u
Background. Cardiovascular (CVD) risk factors have been shown to cluster in some children. This has been shown in children from the age of nine years, but recently we found no clustering in six-year old children. It is uncertain when clustering develops and which parameters are related to the development of clustered CVD risk. Methods. A longitudinal study including 484 children aged six years. Th
Objective: The aim of this study was to investigate whether self-administered Emotional Freedom Techniques (EFT) lead to reduced pain perception, increased acceptance and coping ability, and better health-related quality of life in individuals with fibromyalgia. Methods: Eighty-six women, diagnosed with fibromyalgia and on sick leave for at least 3 months, were randomly assigned to a treatment gro
1 We investigated morphological responses of the submerged macrophyte Myriophyllum spicatum L. to water depth and wave exposure when grown in the same substrate at two sites in two eutrophic lakes. Periphyton production was 4-8 times higher at sheltered than at wave-exposed sites and its influence was further investigated in a glasshouse experiment. Morphological responses in both experiments were
Nanowires were grown by means of a novel aerosol-based method called Aerotaxy. Here an aerosol of Au catalyst nanoparticles in N-2 is mixed with MOVPE precursors in a flow-through reactor at atmospheric pressure, whereby nanowires are produced continuously in high concentrations. We demonstrate the possibility of in situ doping of the NWs and the realization of well-controlled p-type GaAs nanowire
Type 1 diabetes is characterized by autoimmurte destruction of pancreatic beta-cells in genetically susceptible individuals. Triggers of islet autoimmunity, time course, and the precise mechanisms responsible for the progressive beta-cell failure are not completely understood. The recent escalation of obesity in affluent countries has been suggested to contribute to the increased incidence of type
PURPOSE: Professional electricians are highly subjected to electrical injuries. Previous studies describing symptoms after electrical injury have not included people with less severe initial injuries. The purpose of the present study was to describe symptoms at different time points after electrical injury, the impact of "no-let-go" phenomenon and different electrical potential [high voltage (HV)
På senare år har korruption i internationella affärstransaktioner blivit till ett växande problem. Den internationella viljan att förebygga korruption har ökat i takt med att kunskapen om korruptionens skadliga verkningar blivit större. Detta har resulterat i en rad mellanstatliga instrument som Sverige anslutit sig till. Instrumenten ålägger medlemsstaterna att enskilt inrätta effektiva system ge
Teknisk innovation inom den finansiella sektorn och inom elektronisk han- del har växt dom senaste åren. Detta har bidragit till att nuvarande betal- ningsmarknad erbjuder allt fler digitala betalmetoder för enskilda- och juri- diska personer. En utav dessa betalmetoder är Bitcoin. Bitcoin fick sitt ge- nomslag efter finanskrisen 2009 och har sedan dess lockat användare värl- den över. Bitcoin är Technical innovation within the financial sector and electronic commerce has grown in recent years. This has contributed to the current payment mar- ket offering an increasing number of digital payment methods for individu- als and legal entities. One of these payment methods is Bitcoin. Bitcoin gai- ned prominence after the 2009 financial crisis and has since attracted users worldwide. Bitcoin is
Under de senaste åren har en rad plattformsföretag etablerat sig inom olika sektorer av samhället och vid det här laget är de flesta människor bekanta med företag som Foodora och Uber. Uppkomsten och den starka etableringen av gig-ekonomin har skapat en hel del oklarheter vad gäller arbetsrättsliga frågor. Gig-ekonomin bygger på en treparts-relation mellan tjänsteleverantören, användaren/kunden ocIn recent years, a number of platform companies have established themselves in various sectors of society and by now most people are familiar with companies such as Foodora and Uber. The rise and the big establishment of the gig economy has created a lot of uncertainty regarding labor law issues. The gig economy is based on a tripartite relationship between the service provider, the user/customer
Cities around the world are leading the race toward an environmentally sustainable future, but one of their major obstacles have been the personal automobile. The movement of people using public transportation often has a far lower impact than the personal automobile, but these systems are often rigid and expensive to build and operator. Now, with the emergence of intelligent transport systems – a
The right of public access, in Swedish called allemansrätten, gives people the opportunity to roam freely in nature. Whether one prefers to explore nature by foot, on a bike or on a pair of skis is up to the individual since the right of public access includes all the above-mentioned types of transportation. Today there seems to be a trend that the usage of cross-country skiing tracks and mountain
Aim: The aim of this paper was to shed light on the different methods/strategies that Anti-Brand Communities (ABCs) use in order to cause harm to particular brands. Purpose: The purpose of this paper is to offer assistance to brand managers through Anti-Brand Community-insights, as a means of combating the increasingly growing number of ABCs. Research Question: What methods/strategies do anti-b
