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In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results. This was done for natural splice sites of clinically relevant genes in hereditary breast/ovarian cancer (HBOC) and Lynch syndrome.
Title: A Case Study of Motivators Behind The Use of Social Networking Sites Purpose: The purpose of this study is to gain in-depth understanding of the motivating factors behind the target groups engagement with company profiles within Social Networking sites. Furthermore the aim is to gain knowledge about what content is attractive on a company profile within a Social Networking site and the wome
Purpose – The purpose of this master thesis is to examine the profile of contemporary skills and knowledge provided in Logistics and Supply Chain Management (LSCM) postgraduate programs offered by Swedish universities and compares them with job requirements. Design/methodology/approach – This master thesis employs the desk-based research involving content analysis based on 14 postgraduate LSCM pro
Many primates produce copulation calls, but we have surprisingly little data on what human sex sounds like. I present 34 h of audio recordings from 2239 authentic sexual episodes shared online. These include partnered sex or masturbation, but each recording has only one main vocalizer (1950 female, 289 male). Both acoustic features and arousal ratings from an online perceptual experiment with 109
Experiences of intoxication elude scientific research because of their immediate and ‘inner’ nature for the intoxicated individual. In this chapter, we show how ‘trip reports’ – reports of psychedelic intoxication – from online drug information forums and libraries allow for further understanding the experience of psychedelic intoxication from LSD, DMT and psilocybin by examining psychonauts’ (i.e
Denna uppsats utgår från premissen att barns rätt till integritet är en del av barns rätt till deltagande online. Barnrättslagstiftning presenterar i sig ett di-lemma som rör barns rätt till delaktighet och skydd, där en rättighetsbaserad strategi anses vara det mest effektiva sättet att ta itu med dilemmat. En rättig-hetsbaserad strategi förespråkar en balans mellan barns behov av skydd online ocThis thesis starts from the premise that children’s right to privacy is a part and parcel for children’s right to participation online. Children’s rights law inher-ently presents a dilemma relating to children’s right to participation and protec-tion, where a rights-based approached is considered the most effective way to address the dilemma. A rights-based approach is legal framework that can bal
In 1997, the concept of personal branding was popularized. Since then our world has changed, and is still changing, with the use of technology, digitization and so-cial media. Constructing and managing one's personal brand is something that to-day largely occurs in the online environment. Those who are considered comfor-table in, and accustomed to, the social media environment are referred to
There are many projects in Mozambique for poverty reduction. One of these projects is funded by Millennium Challenge Account (MCA) and is aimed to install a total of 600 rural water points in the provinces of Nampula and Cabo Delgado. Each water point consists of a drilled well, a water pump and a communal washing basin. Vertical Electrical Sounding (VES) was used for assessing the uitability of
With their highly sensitive visual systems, the arthropods have evolved a remarkable capacity to orient and navigate at night. Whereas some navigate under the open sky, and take full advantage of the celestial cues available there, others navigate in more difficult conditions, such as through the dense understory of a tropical rainforest. Four major classes of orientation are performed by arthropo
Popular Abstract in Swedish Ofrivilligt urinläckage, urininkontinens, omfattar mer än 50 miljoner människor i världen, varav cirka 500 000 i Sverige. Av dessa beräknas 2/3 vara kvinnor. Ofrivilligt urinläckage är ett medicinskt och socialt handikapp för den drabbade, operation och hjälpmedel förorsakar samhället stora kostnader. Risken för urininkontinens ökar med stigande ålder. I svenska studierAbstract Pelvic floor disorders (PFD) represent a major public health issue worldwide. Aims of this work Study I: to investigate associations between preoperative resting urethral parameters (MUCP, FL and CA) and objective outcome of laparoscopic colposuspension and, if possible, to identify cutoff values useful in clinical practice. Study II: to investigate a group of perimenopausal women reporti
Melanoma is an aggressive disease that arises from deregulated signaling events in melanocytes. The KIT receptor tyrosine kinase and the Microphthalmia-associated transcription factor (MITF) are two essential components that are required for the normal physiology of melanocyte development and function. Consequently, aberrant activities of these factors are involved in the development of melanoma.
Popular Abstract in Swedish Immunsystemet är ett invecklat och komplext system som finns överallt i kroppen och som inte är begränsat till ett enda organ. Vi utsätts hela tiden för ”angrepp” från mikro-organismer (t.ex. bakterier eller virus) men också för främmande ämnen som kan vara skadliga eller giftiga. Immunsystemets huvudfunktion är att hjälpa kroppen att känna igen dessa ”angripare” och atThe overall aim of this PhD project was to gain insight into the incidence of primary immunodeficiency (PID) in southern Sweden and to optimize diagnostic and treatment measures for these patients. We estimated the occurrence rate of PID in the pediatric population of southern Sweden during a period of 4 years and described the demographic, clinical and immunological characteristics of the identif
The use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. In the present thesis I studied the silencing of transgenes induced upon differentiation of neural pro
Popular Abstract in Swedish Som en blixt från klar himmel drabbas en ung, och till synes frisk person, av hjärnblödning. Denna stroke leder till demens och efterföljande nya blödningar leder slutligen till en för tidig död. Man har kunnat visa att denna sjukdom beror på att en variant av ett visst protein, cystatin C, tvinnar ihop sig till rep-liknande långa fibriller. Dessa fibriller ansamlas sedAmyloidosis is a group of diseases characterized by a change in protein conformation resulting in aggregation and tissue deposition of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic and persons carrying the corresponding gene suffer from massive cerebral amyloidosis leading to brain hemorrhage and death. Amyloidogenic proteins like cystatin C and prion protein
Fourteen tree-ring chronologies developed from 788 peatland Scots pines sampled at sites in Estonia, Belarus and Sweden were compared for common growth trends and possible links to regional climate dynamics. Several synchronous growth release events were detected, especially during the 1910s, 1930s, and around 1970 and 1990, indicating that hydrological shifts and associated tree growth responses
The purpose with this study is to enhance our knowledge about virtual co-creation by investigating in the underlying role of the co-creating consumer and how companies manage co-creation as well as studying how power is distributed within this consumer- company relationship. The research undertakes a qualitative research strategy with an abductive methodological approach. Netnography is the chosen
Primär hyperparathyroidism, pHPT, är en relativt vanlig endokrinologisk sjukdom som karaktäriseras av förhöjd utsöndring av bisköldkörtelhormon, PTH, i förhållande till kalciumnivån i blodet. Sjukdomen är vanligast hos äldre och kvinnor, och orsakas oftast av en godartad tumör i en bisköldkörtel (80–85% av fallen) eller mer diffus förstoring av flera bisköldkörtlar. Bisköldkörtlarnas fysiologiska
Brevmall Postal address P.O.Box 196, SE-221 00 Lund, Sweden Visiting address Tegnérsplatsen 4 Telephone +46 46-222 00 00 Telefax +46 46-222 02 30 Internet www.iiiee.lu.se August 2017 Masters Programme in Environmental Management and Policy (EMP) It is no longer possible to be admitted to the below programme outline with the two different entry tracks for the basic block of courses. Students admitt
https://www.iiiee.lu.se/sites/iiiee.lu.se/files/emp_programme_outline_with_last_admission_in_academic_year_2017.pdf - 2026-07-13
In this thesis, the GW approximation (GWA, Green's function G times screened interaction W) and the Hubbard I approximation (HIA) are combined in a non-self-consistent one-shot calculation to determine the electronic structure of a one-dimensional strongly-correlated model. The scheme was chosen to incorporate both screening effects through the GWA and strong on-site correlations through the a
Recent urban development has serious consequences such as limited space and expanded urban sprawl which lead to complex problems on the edge. Also, there is large number of urbanization where people from rural areas try to find better opportunities by moving to big cities. Furthermore, fringe area seems like an unplanned area which lose its identity and do not optimize its potentials. Those situat
