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The nervous system is constantly infiltrated by blood-derived sentinels known as perivascular macrophages. Their immediate precursors have not yet been identified in situ and the mechanism that governs their recruitment is mostly unknown. Here, we provide evidence that CD68 (+)GR(-) monocytes can give rise to perivascular macrophages in mice suffering from endotoxemia. After adhesion to the endoth

Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.

Streptococcus pyogenes (group A streptococcus) causes a variety of diseases, including acute pharyngitis, impetigo, rheumatic fever and the streptococcal toxic shock syndrome. Moreover, S. pyogenes was responsible for the classical example of a nosocomial infection, the epidemics of puerperal fever (childbed fever) that caused the death of numerous women in earlier centuries. The most extensively

Disturbed haemostasis is a central finding in severe Streptococcus pyogenes infection. In particular, microthrombi are found both at the local site of infection and at distant sites. Platelets are responsible for maintaining vascular function and haemostasis. We report here that M1 protein of S. pyogenes triggers immune-mediated platelet activation and thrombus formation. M1 protein is released fr

The gene for an IgA-binding protein from a group A streptococcal strain was cloned and expressed in Escherichia coli. The IgA-binding protein, called protein Arp, was purified on IgA-Sepharose, allowing complete purification in a single step. Analysis of protein Arp by Western immunoblotting demonstrated a major IgA-binding band, with an apparent molecular weight of 42 kD. The purified protein was

Recently, to reach zero emission levels, some new energy systems based on fuel cells have been developed. This paper presents a review of investigations of these systems by thermodynamics performance, mainly, energy and exergy analysis. With energy analysis, the performance of an energy conversion system cannot be effectively and accurately evaluated. But exergy analysis complements and reinforces

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https://www.jur.lu.se/kontakt/oppettider-och-allman-kontaktinformation - 2026-10-05

Popular Abstract in Swedish Denna avhandling handlar om arbetarförfattaren Ivar Lo-Johanssons modernitet, sådan den kommer till uttryck i de sk. statarromanerna: Godnatt, jord (1933), Bara en mor (1939) och Traktorn (1943). Först undersöks hur modernisering och modernitet skildras i romanerna och därefter hur författaren förhåller sig till den litterära riktning som kommit att symbolisera den esteThis dissertation examines the modernity of the Swedish proletarian author Ivar Lo-Johansson (1901-1990), as manifested in the so-called 'statare' novels: Godnatt, jord (Breaking Free, 1933), Bara en mor (Only a Mother, 1939), and Traktorn (1943). The dissertation examines, on the one hand, modernisation and modernity as the topoi of these novels, and on the other, how the author relates to the li

NYTT FRÅN LUNDS UNIVERSITET Mejlutskick på svenska och engelska som vänder sig till fakultetskommunikatörer vid Lunds universitet för vidarespridning i fakultets- och institutionskanaler - Nr 22 v 25 - 2020. Nytt om LU@ScienceVillage Under våren har arbetet med utformning av verksamhetsbeskrivningar fortsatt tillsammans med berörda avdelningar och institutioner som är aktuella för en etablering i

https://www.cec.lu.se/sites/cec.lu.se/files/lu-gemensamt_mejlutskick_nr_22-2020-_v25.pdf - 2026-10-06

https://www.msf.lu.se/research/mr-physics-group/software/lupe-lund-perfusion-program - 2026-10-05

This thesis is about autistic women. It is about how we, as a society, construct and perceive normality and motherhood as a normative ideal for women. It is also about a dis/ability that often goes unnoticed since autism is not defined by any visible markers. Rather, autism is categorized by behaviour considered atypical through the medical gaze. How to make visible the invisible, the in-between