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Molecular Classification of Bladder Cancer

Popular Abstract in Swedish Cancer i urinblåsan är ett stort hälsoproblem i Sverige och världen. Det är den femte vanligaste cancerformen i Sverige och är den som belastar sjukvården med högst kostnader per patient. Ungefär tre fjärdedelar av de drabbade är män och patienterna är oftast kring 60-80 år gamla. Den behandling vi idag kan erbjuda en person som drabbas av blåscancer har inte förändratsDecisions in the treatment of bladder cancer today are based on clinical and pathological risk variables such as tumor stage and tumor grade. The importance of these conventional risk variables is well documented since more than 10 years, and they are used routinely in the clinics. Over the last ten years, cancer research has seen a gradual transition towards personalized medicine, i.e. the exploi

Professionalizzazione, Gender, e Animato nelle Comunità di File Sharing Globale

Abstract in Italian Nell’aprile 2011, al famoso logo della community di file sharing globale The Pirate Bay fu aggiunta l’immagine di una lente di ingrandimento e il nome del sito cambiò in The Research Bay. Gli utenti che cliccarono sul nuovo logo furono reindirizzati su un sondaggio online; durante le 72 ore di svolgimento dello studio, 75.000 file-sharer compilarono il questionario preparato da

Privatizing an Uncontested Public Good - The Rise of Transnational Corporate Military Service Provision

The provision of military and armed security services typically is the monopoly domain of the state. With the end of the Cold War legitimate private firms, however, expanded as worldwide providers of military and security services. The proliferation of private military companies echoes back to pre-modern eras when it was customary for state rulers to allocate force and security through the market.

The Evolution of ESDP: Recent Political Developments and Social Constructivism

The formation of ESDP (European Security and Defense Policy) is one of the most important building blocks shaping the European security structure and the European integration process since the beginning of the 21st century. Even though the integration engine was injured by the rejection of the European Constitutional Treaty in France and the Netherlands, the ESDP can be seen as currently one of th

Utrymningshiss som utrymningsväg – En analys av möjligheten att använda hissar vid utrymningsdimensionering

Elevators has for a long period of time been regarded as unsafe to use as a means of egress. This is an opinion that has shifted in the last couple of years as technical solutions has been found to the initial problems when using elevators as an escape route. This report investigates the possibility to replace a staircase with emergency elevators as a means of egress in a buildning. The report als

BNP-prognoser och mål för inflationsprognoser - Sannolikhetsskattningar av framtida vändningspunkter i amerikansk och svensk BNP

Svensson (1997) föreslår att centralbanker på grund av implementerings- och utvärderingssvårigheter hos inflationsmål även bör ha ett mål för inflationsprognoser. Han argumenterar för detta med hjälp av en teoretisk modell som antar att den korta räntan, som centralbanken kontrollerar, påverkar BNP-gapet med en periods fördröjning, vilket sedan påverkar inflationen efter ännu en period. För att ma

Management of hydrogen sulfide in anaerobic digestion of enzyme pretreated marine macro-algae

Enzymatic pretreatment of algae by means of cellulose degrading enzyme was evaluated through lab-scale and pilot-scale experiments. The degradation efficiency of the enzyme depended on the initial physical quality of the algae. Lab-scale batch anaerobic digestion experiments showed comparatively low methane potential for the pretreated algae at both mesophilic and thermophilic temperatures. Howeve

Food security and climate change in drought-sensitive savanna zones of Ghana

Desertification, climate variability and food security are closely linked through drought, land cover changes, and climate and biological feedbacks. In Ghana, only few studies have documented these linkages. To establish this link the study provides historical and predicted climatic changes for two drought sensitive agro-ecological zones in Ghana and further determines how these changes have influ

Integration study on a two-stage fermentation process for the production of biohydrogen

In order to make the hydrogen economy fully sustainable, renewable resources have to be employed for its production. Simulation models, developed with Aspen Plus to calculate mass and energy balances, will be used to integrate the process steps necessary to produce pure hydrogen from biomass in a 2-stage fermentation process. The main challenge is the reduction of water and heat demand connected t

Stadsplaneringens betydelse för segregation i svenska städer - en kartläggning av kommunernas arbete mot segregation

Segregation är ett föränderligt tillstånd som är komplext och påverkar såväl enskilda individer som samhället i stort. Exempelvis är stadsplaneringen en bakomliggande orsak som kan påverkar segregationen i en stad. För att det verkligen ska kunna ske en förbättring är det emellertid av stor vikt att åtgärder vidtas på olika plan och av olika aktörer. Det ursprungliga syftet bakom arbete är att utSegregation is a changing condition that is complex and affects individuals but also the society. Urban planning is for example an underlying cause that can affect segregation in a city. However, in order for an improvement, it is of great importance that measures are taken at different levels and by different actors. The primary purpose of the report was to study the impact that urban planning h

Bioactive adrenomedullin in sepsis patients in the emergency department is associated with mortality, organ failure and admission to intensive care

BackgroundAdrenomedullin is a vasoactive hormone with potentially prognostic and therapeutic value, which mainly has been investigated in intensive care unit (ICU) settings. The triaging in the emergency department (ED) of patients to the right level of care is crucial for patient outcome.ObjectivesThe primary aim of this study was to investigate the association of bioactive adrenomedullin (bio-AD

Is frailty associated with long-term survival, neurological function and patient-reported outcomes after in-hospital cardiac arrest? – A Swedish cohort study

Background: Frailty is associated with poor 30-days survival after in-hospital cardiac arrests (IHCA). The aim was to assess how pre-arrest frailty was associated with long-term survival, neurological function and patient-reported outcomes in elderly survivors after IHCA. Methods: Patients aged ≥ 65 years with IHCA at Karolinska University Hospital between 2013–2021 were studied. Frailty was asses

A robust Bayesian bias-adjusted random effects model for consideration of uncertainty about bias terms in evidence synthesis

Meta-analysis is a statistical method used in evidence synthesis for combining, analyzing and summarizing studies that have the same target endpoint and aims to derive a pooled quantitative estimate using fixed and random effects models or network models. Differences among included studies depend on variations in target populations (ie, heterogeneity) and variations in study quality due to study d

Iterative importance sampling with Markov chain Monte Carlo sampling in robust Bayesian analysis

Bayesian inference under a set of priors, called robust Bayesian analysis, allows for estimation of parameters within a model and quantification of epistemic uncertainty in quantities of interest by bounded (or imprecise) probability. Iterative importance sampling can be used to estimate bounds on the quantity of interest by optimizing over the set of priors. A method for iterative importance samp

Pulseless electrical activity is associated with improved survival in out-of-hospital cardiac arrest with initial non-shockable rhythm

Objective: To describe the prevalence, baseline characteristics and factors associated with survival in out-of-hospital cardiac arrest (OHCA) with initial non-shockable rhythm sub-grouped into pulseless electrical activity (PEA) and asystole as presenting rhythm. Methods: The Swedish Registry of Cardiopulmonary Resuscitation is a prospectively recorded nationwide registry of modified Utstein param

Flammability limits of Low Btu gases : Computations in a perfectly stirred reactor and experiments

The demand for gas turbines suitable for Low Btu gases is increasing worldwide. This paper presents a theoretical and experimental investigation of the flammability limits of Low Btu gases for gas turbine applications. Most modern gas turbines utilize premixed combustion, making it important to know at which fuel-air ratio the flame extinguishes. The flammability limit for a gaseous fuel is a prop

High-sensitivity troponin T is an important independent predictor in addition to the Simplified Acute Physiology Score for short-term ICU mortality, particularly in patients with sepsis

Purpose: Elevated cardiac troponin levels have been shown to be associated with a poor prognosis under some intensive care conditions. This study investigated whether inclusion of high-sensitivity troponin T (hsTnT) increased the prognostic accuracy of the Simplified Acute Physiology Score (SAPS 3) for general intensive care unit (ICU) patients, cardiac arrest patients, or patients with a non-card