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The importance of lung microenvironment

A microenvironment is an area with a specific composition of mainly extracellular matrix (ECM) components surrounding the cells. The tight interactions between matrix molecules and cells are very important, and it is now well known that the ECM components direct cell activity and function and regulate remodeling processes during both homeostasis and pathological conditions. The lung is a very comp

Reversing the Fuel-Electricity System Provides for Complete Fossil Fuel Replacement and a Stable Grid

As the total cost of renewable electricity falls lower than the price of fossil fuel, not only can electricity be used to replace fossil fuels using batteries in vehicles but it can also be used to produce fuels. This makes it possible to replace fuels in sectors not easily directly electrified. It also provides new ways of balancing the electricity system. When renewable electricity is cheap a lo

Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease

Mouse embryonic stem cell (mESC) lines were derived by crossing heterozygous transgenic (tg) mice expressing green fluorescent protein (GFP) under the control of the rat tyrosine hydroxylase (TH) promoter, with homozygous alpha-synuclein (aSYN) mice expressing human mutant SNCAA53T under the control of the mouse Prion promoter (MoPrP), or wildtype (WT) mice. The expression of GFP and human aSYN wa

Bedömning av neurologisk prognos efter hjärtstopp : Uppdaterade rekommendationer från Svenska HLR-rådets expertgrupp

European Resuscitation Council (ERC) issued updated guidelines for postresuscitation care in 2015. This paper provides updated Swedish recommendations for neurological prognostication of patients remaining unconscious after cardiac arrest (CA). The prognostication should be based on independent methods; clinical and neurophysiological examinations, imaging and biomarkers. It should not be performe

The new EU rules on electronic insolvency registers

This paper deals with those provisions of the new EU Regulation No. 2015/848 on Insolvency Proceedings (Recast) that create a system of national insolvency registers and establish a decentralized system for the interconnection of such registers by means of the European e-Justice Portal.

Constructing social identity through multiple "us and them" : a grounded theory study of how contextual factors are manifested in the lives of residents of a vulnerable district in Brazil

The association between contextual factors and health inequalities is well documented, also in Brazil. However, questions about how contextual factors actually affect health and well-being persist. The aim of this qualitative study was to explore how contextual factors-i.e., social stratification and neighborhood opportunity structures-are manifested in the lives of the residents of a vulnerable d

Implementation of an economic model to simulate manufacturing costs

An economic model describing manufacturing costs is implemented within the frame of a case study. The implemented economic model is developed to enable analyses of the cost items and parameters influencing the cost of a part or a batch and also to make simulations for the purpose of investigating the economic outcome of future development activities. The aim of the case study was to identify activ

Software code generation for dynamic dataflow programs

In this paper we address the problem of generating efficient software implementations for a large class of dataflow programs that is characterized by highly data-dependent behavior and which is therefore in general not amenable to compile-time scheduling. Previous work on implementing dataflow programs has emphasized classes of stream processing algorithms that exhibit sufficiently regular behavio

Energy use and carbon emissions: From decoupling and transitions to sufficiency?

The paper examines and illustrates different trends in relation to historical energy use-related intensities and corresponding CO2 emission trends. The methodology encompasses a decomposition quantitative approach for estimating decoupling trends to energy use and economic and demographic parameters driving CO2 emission levels. The analysis covers both global and regional trends for the period 197