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Background: Overdiagnosis and subsequent overtreatment are important side effects of screening for, and early detection of, prostate cancer (PCa). Active surveillance (AS) is of growing interest as an alternative to radical treatment of low-risk PCa. Objective: To update our experience in the largest worldwide prospective AS cohort. Design, setting, and participants: Eligible patients had clinical
Development of B-lymphoid cells in the bone marrow is a process under strict control of a hierarchy of transcription factors. To understand the development of a B-lymphoid-restricted functional network of transcription factors, we have investigated the cell autonomous role of the transcription factor EBF1 in early B cell development. This revealed that even though transplanted EBF1-deficient fetal
Food security can be defined as stable access to food of good nutritional quality. In Sub Saharan Africa access to food is strongly linked to local food production and the capacity to generate enough calories to sustain the local population. Therefore it is important in these regions to generate not only sufficiently high yields but also to reduce interannual variability in food production. Tradit
If water stays on wood surfaces or is trapped in gaps, the wood is supplied with water for a long period of time and high local moisture contents are reached. This can lead to decay by rot fungi, and it is therefore important to avoid such water traps in order to limit the decay rate. This paper presents two methods: one for determination of duration of surface moisture on wood surfaces and one fo
The rate coefficients for the chemical reactions (species loss rates, quenching excluded) of the refrigerants CH2F2 (HFC-32), CHClF2 (HFC-22) and CH2FCF3 (HFC-134a), and the solvent CH3CCl3 with O(D-1) are determined relative to CH4 + O(D-1) at 298 K. The resulting rates k(CH2F2 + O(D-1)) = (4.78 +/- 1.03) x 10 (11) cm(3) molecule (1) s (1), k(CHClF2 + O(D-1)) = (8.69 +/- 1.72) x 10 (11) cm(3) mol
Eae5 in rats was originally identified in two F-2 intercrosses, (DA x BN) and (E3 X DA), displaying linkage to CNS inflammation and disease severity in experimental autoimmune encephalomyelitis (EAE), respectively. This region overlaps with an arthritis locus, Pia4, which was also identified in the (E3 X DA) cross. Two congenic strains, BN.DA-Eae5 and BN.DA-Eae5.R1, encompassing the previously des
The purpose of this thesis is to provide insight into the recruitment and selection processes of high-tech companies in China and to advice returning Chinese overseas students on these recruitment and selection processes. We collected empirical data from respondents by using semi-structured interviews for the following qualitative analysis. Interview guide, selection of respondents, conduction of
Property rights systems and their relationship to the informal spaces are a contested and highly relevant part of contemporary development discourse. This study explores the reproduction of the concept of the informal in urban space. The central problematic of this study then departs by asking in what ways does the debate on property rights and the informal economy emerge as a representation of sp
Secondary packaging solutions presently used to package food goods in e-commerce supply chain are either taken from old supply chains, or sub-optimally developed in a non-holistic manner. Due to the increase use of the Internet in Europe to perform online food purchases, secondary packaging must be adapted to meet these new needs. Therefore, a secondary packaging solution for a Dutch e-grocer was
In the last few decades, researchers have identified many systematic errors – cognitive biases – in the human mind. The predominant notion of human beings as rational have gradually been flawed, in one context after another. In the last few years scholars have approached the question of what policy implications should be derived from these findings and what solutions there might be. Three main phi
For this research, two satellite products were used to see if it was possible to improve the resolution and quality of the global radiation interpolation in the Netherlands. The first data source was from the Climate Monitoring Satellite Application Facility (CM-SAF). The second data source was the Surface Insolation under Clear and Cloudy Skies (SICCS) from the KNMI. Both products were available f
Problem discussion: Uptime availability is an essential parameter in profitable production within the oil and gas industry. Several installations have a problem achieving their uptime availability target as platforms stand still for shorter or longer periods of time. A reduced uptime availability can cause significant losses for the platform. The power supply is a constant subject within the indus
The health and environmental impacts of food consumption are increasingly recognized as sustainability issues in developed countries. Therefore, promotion of sustainable diets is becoming more popular among governments and International NGOs. However, the question persists of how best to do this. While the determinants of behavioural change have been studied extensively, the motivations behind beh
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Personal computers (PC) have become an indispensable product in modern life. Along with the growing volume of computers, the environmental burden and impact at the end-of-life phase known as e-waste become significant. Considering the material-intensive nature of the production of computers, and the environmental burdens caused by landfills, incinerations and improper recycling activities, persona
Title: Default Risk in Equity Returns: a Study on Augmentation of the Three-Factor Model of Fama and French with Default Risk Factor Seminar date: June 7th, 2010 Course: Master Degree Project in Finance, 15 ECTS, BUSM65 Authors: Holst, Aracelly and Martynenko, Olena Supervisor: Forssbaeck, Jens Key words: ASSET PRICING, DEFAULT RISK, FACTOR MIMICKING PORTFOLIO, FACTOR RISK PREMIUM Purpose: T
Cross-border integration between Greece, Turkey and Bulgaria has been recently dominated by traditional perception of political diplomacy that overrides the considerations for economic cooperation. This project suggests that more in-depth case analysis of the Evros-Maritza-Meric Euroregion will elucidate the evolution of this concept. The existence of long-term barriers in the cross-border region
Key words: Corporate environmentalism, ecologic-economic decision-making, CSR worldviews Purpose: To explore environmental decision-aming processes at managers at Skanska, also with regard to enviornmental decison-making conceptualizations in theory. Method: The research of the thesis is based on a qualitative approach through the use of semi-structured and open interviews. Furthermore an interpre
"The technology for planning and delivering radiotherapy has in the last decade undergone some revolutionary development and it is now possible to perform complex treatments such as stereotactic treatments and treatments using dynamic wedges, multileaf collimator and intensity modulation. The more precise limits surrounding the PTV have made it of utmost interest to be able to verify calculat
Climate change has emerged as the most prominent of the global environment issues and there is a need to evaluate its impact on the agriculture. General Circulation Models (GCMs) which are considered as the most advance tools for estimating future climate change scenarios operate on coarse resolutions. It is for this reason the climate change model MAGICC coupled to SCENGEN developed by the IPCC w
