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The flexibility demands in manufacturing are severe, e.g., for rapid-change-over to new product variants, while robots are flexible machines that potentially can be adapted to a large variety of production tasks. Task definitions such as explicit robot programs are hardly reusable from an application point-of-view. To improve the situation, a knowledge-based approach exploiting distributed declara

Agile has been touted as a concept to deal with and succeed in the fast-paced environment in which companies operate today. Based on this concept, practitioners have created frameworks and practices that have proven to bring benefits in software development. Looking to extend these benefits beyond software development, companies are launching large-scale agile transformation initiatives, however,

Background: The open abdomen is an innovation that greatly improved surgical understanding of damage control, temporary abdominal closure, staged abdominal reconstruction, viscera and enteric fistula care, and abdominal wall reconstruction. This article provides an evidence-informed, expert, comprehensive narrative review of the open abdomen in trauma, acute care, and vascular and endovascular sur

Background: Lead exposure is associated with cardiovascular disease. Atherosclerosis has been hypothesized to be one of the underlying mechanisms behind this association. Aim: To investigate whether lead exposure is associated with an increased risk of atherosclerosis in the carotid arteries in a large Swedish population-based cohort. Methods: We performed a cross-sectional study using data from t

This report examines developments since 2000 in relation to the areas covered by the four Danish EU opt-outs, including developments that can be assumed to be consequences of the Lisbon Treaty. The report also evaluates the impact on Denmark within each opt-out area as well as on Denmark’s position in EU.Since 1993, Denmark has had four opt-outs covering defence policy, the Economic and Monetary U

INTRODUCTION:  BAY 81-8973, a full-length recombinant factor VIII for hemophilia A treatment, has been extensively evaluated in previously treated patients in the LEOPOLD (Long-Term Efficacy Open-Label Program in Severe Hemophilia A Disease) clinical trials.AIM:  To assess BAY 81-8973 efficacy and safety when used for bleed prophylaxis and treatment in previously untreated/minimally treated patien

This interdisciplinary thesis examines the nexus of memory, war, and digitality inthe context of the Russian invasion of Ukraine. Since 2014, the unfolding Russianwar against Ukraine has epitomised how rapid technological developments haveprofoundly altered the ways in which warfare is depicted, perceived, and waged intoday’s world. These transformations have enabled new forms of engagement withwa

Background: During the transition to parenthood, fathers face psychosocial changes that are accompanied by uncertainty and insecurity. Feelings of insecurity may affect fathers’ experiences of pregnancy and childbirth, adjustment to the paternal role, and bonding with their child. There is a need to better understand fathers’ experiences of security and the causal and constitutional factors involv

Enzymes, as efficient and environmentally friendly catalysts, have gainedsignificant scientific and industrial attention for their mild operating conditions,high substrate selectivity and reusability when immobilized. Among them, lipasesdominate the global industrial enzyme market, catalyzing various reactions with afocus on substrate specificity and selectivity. This thesis investigates theoptimi

The thesis addresses the question of how to mitigate climate change by studying the emergence of solar photovoltaic energy as an example of a low carbon industry. By outlining the social conditions behind the growth of that industry, I aim to further the understanding of low carbon industrial development in general. The dissertation is a historical comparative study of solar photovoltaic developme

Background: People with intellectual disabilities (ID) may be at higher risk of psychiatric disorders than the general population. However, few studies investigate the role of demographic factors.Methods: This register-based study includes all people living in Skåne, Sweden, on January 1st, 2014. The ID cohort comprises those who received support and service for people with functional impairments

While numerous membrane-bound complement inhibitors protect the body's cells from innate immunity's autoaggression, soluble inhibitors like complement factor I (FI) are rarely produced outside the liver. Previously, we reported the expression of FI in non-small cell lung cancer (NSCLC) cell lines. Now, we assessed the content of FI in cancer biopsies from lung cancer patients and associated the re

Background. The links between chronic kidney disease (CKD) and the high burden of cardiovascular disease remain unclear. We aimed to explore the association between selected inflammatory and angiogenic biomarkers, kidney function and long-term outcome in patients with an acute coronary syndrome (ACS) and to test the hypothesis that CKD status modifies this association. Methods. A total of 1293 ACS

Treatment with the anti-angiogenic drug bevacizumab in addition to chemotherapy has shown efficacy for breast cancer in some clinical trials, but better biomarkers are needed to optimally select patients for treatment. Here, we present an omics approach where DNA methylation profiles are integrated with gene expression and results from proteomic data in breast cancer patients to predict response t

Breast cancer and type 2 diabetes are major health concerns worldwide. This thesis has focused on novel non-canonical roles of two complement inhibitors, which led to the discovery of new mechanisms and factors at play in these diseases. The sushi domain-containing protein 4 (SUSD4) was previously portrayed as a breast cancer suppressor, but no mechanism was identified. In paper I, using a syngene

Generally speaking, Computer based numerical hydrological models have been playing a very central role during the last decades in dealing with water resources related problems. Various kinds of conceptual, physical and stochastical models have been developed. Perhaps the most important contribution of those models is the ability of simplifying and schematizing a complex problem in the nature and s

Background: National stroke clinical quality registries/audits support improvements in stroke care. In a 2016 systematic review, 28 registries were identified. Since 2016 there have been important advances in stroke care, including the development of thrombectomy services. Therefore, we sought to understand whether registries have evolved with these advances in care. The aim of this systematic rev

OBJECTIVES: The Apollo study was designed to support the clinical performance verification of the adjusted cutoffs of the Elecsys® β-Amyloid(1-42) (Aβ42) cerebrospinal fluid (CSF) II, β-Amyloid(1-40) (Aβ40) CSF, Phospho-Tau (181P) (pTau) CSF and Total-Tau (tTau) CSF immunoassays (Roche Diagnostics International Ltd) for measuring fresh CSF samples, and assess the concordance of the Elecsys CSF pTa

Pharmaceutical manufacturing of parenteral injections must be fine-tuned to yield a stable API through efficient production methods. Assessing a products processability is essential to ensure consistent manufacturing and safe drug administration, of which powder flowability and dissolution both have a direct impact. Spray drying is a particle engineering technique to modify these parameters, howev