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This paper presents and discusses results from the research project LETS 2050 that studies the governance challenges of a transition to a low-carbon transport and energy system in Sweden by 2050 (www.lets2050.se ). A key starting point of the project was that a low carbon transition is technically possible and economically feasible, while the main challenge is political. At the moment there is an
Amyloid-β (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial temporal lobe. However, there is evidence that, independently of Aβ, age-related tau pathology might be present outside of the medial temporal lobe. We therefore aimed to study age-related Aβ-independent tau deposition outside the medial temporal lobe in two large cohorts and to investigate potential downstr
Human activities in coastal areas have intensified over the last 200 years, impacting also high-latitude regions such as the Baltic Sea. Benthic foraminifera, protists often with calcite shells (tests), are typically well preserved in marine sediments and known to record past bottom-water conditions. Morphological analyses of marine shells acquired by microcomputed tomography (µCT) have made signi
So far, no common environmental and/or phenotypic factor has been associated with melanoma and renal cell carcinoma (RCC). The known risk factors for melanoma include sun exposure, pigmentation and nevus phenotypes(1); risk factors associated with RCC include smoking, obesity and hypertension(2). A recent study of coexisting melanoma and RCC in the same patients supports a genetic predisposition u
Neurofibromatosis-Noonan syndrome (NFNS) is a rare condition with clinical features of both neurofibromatosis type 1 (NF1) and Noonan syndrome (NS). All three syndromes belong to the RASopathies, which are caused by dysregulation of the RAS-MAPK pathway. The major gene involved in NFNS is NF1, but co-occurring NF1 and PTPN11 mutations in NFNS have been reported. Knowledge about possible involvemen
In northern Sweden, plants growing in association with the clonal dwarf shrub Empetrum hermaphroditum usually exhibit limited growth and are N-depleted. Previous studies suggest that this negative effect by E. hermaphroditum may be explained, at least in part, by the release of phenolic compounds, particularly the dihydrostilbene, batatasin-III from foliage to soil. In the present work, we investi
Cognitive Behavioral Therapy (CBT) is the most frequently delivered psychological intervention for adults with chronic pain. The treatment yields modest effect sizes and the mechanisms of action remain understudied and unclear. Efforts are needed to identify treatment mediators that could be used to refine CBT and improve outcomes. The primary aim of this study is to investigate whether pain-relat
Popular Abstract in Swedish Syftet med denna studie var att kartlägga kvinnligt skolledarskap. En enkät sän-des till 235 kvinnliga rektorer. Av dem hade 204 tjänst som skolledare under den tid då undersökningen genomfördes och 173 av dem besvarade enkäten. Det externa bortfallet var alltså ca 15 procent. I den fortsatta framställningen avses med bortfall det interna. Nedan ges en sammanfattning avThe purpose of this study was to chart the situation of women principals. By the time the in-vestigation was made the whole amount of women principals in compulsory school was about 16 percent (90/91). Of 235 contacted women, 204 were serving as principals. 173 responded which means 85 percent. The study shows that responsibility rationality are important in women principals' work. They look afte
This thesis consists of a collection of essays on endogenous trade policies and may briefly be summarized as follows. The first essay empirically examines determinants of bilateral trade protection originating from normative trade theory, endogenous trade-policy studies, and political arguments put forward in the public debate. Overall protection level measures are constructed and the data sample
Popular Abstract in Swedish Svensk populärvetenskaplig sammanfattning Kvartärtidens avlagringar döljer mycket och detaljerad information om palaeoklimatet och de lämpar sig därför väl för att modellera palaeoklimatets förändringar. Inlandsisar är av avgörande betydelse för klimatet under kvartärtiden. Deras tillväxt och avsmältning beror till stor del på klimatiska faktorer, såsom temperatur, nedeThis thesis presents results from studies on geomorphology, lithostratigraphy and ice flow patterns during the final termination and deglaciation of the last Scandinavian Ice Sheet in NE Germany. Ice flow patterns derived from till fabrics and glaciotectonical data indicate that short-lived marginal domes had formed during the advance and the retreat of the last Scandinavian Ice Sheet in NE German
Popular Abstract in Swedish Vad innebär det att muta någon? Vad är egentligen en muta? Denna studie har motiverats av sådana frågor. Det centrala argumentet är att mutor och korruption inte enbart tillhör ett samhälles juridiska sfär utan även dess sociala och moraliska. Om ett agerande ska anses korrupt eller hederligt, klandervärt eller klanderfritt (eller någonting däremellan) avgörs inte enbarWhat does it mean to bribe someone? What is the meaning of bribes? Questions like these have motivated this study. Its central argument is that the folk meanings of “bribes” and “corruption” depend on people’s symbolic demarcations and definitions. Corruption is something we actively define as well as something through which we define ourselves. A specific case has been used: stories about bribes
ABSTRACT Titel: Music teachers’ discretionary power – possibilities and limitations. According to previous research in music education, during recent decades the working conditions for professional music teachers in schools have changed radically. The aim of this thesis is to investigate the working conditions of music teachers by focusing on their experiences of and ideas about discretionary pow
Ever since Brunnby Church was first erected it has been altered and it has crossed boundaries in terms of both religious and national affiliation - from a Catholic to a Lutheran place of worship and from being a Danish to being a Swedish church. The boundaries around and within the church itself have changed, and have become displaced as new forms of worship have been introduced. Boundaries and in
Popular Abstract in Swedish Professionella balettdansare börjar vanligtvis dansa balett redan vid 8–10 års ålder; pojkar ett par år senare än flickor. Det finns flera utbildningsvägar både i Sverige och utomlands. De flesta börjar sin yrkeskarriär vid 18–20 års ålder. I Sverige är pensionsåldern för institutionsdansare 41–44 år, då man efter 20 års anställning vid svenska institutioner kan få maxiBallet dancers have been shown to have frequent problems with the musculoskeletal system, but little is generally known about the prevalences of musculoskeletal disorders and about working conditions of professional ballet dancers in Sweden. The aims of the thesis were: to analyse the prevalence, location and recurrence of self-reported musculoskeletal disorders (pain) in professional ballet danc
Popular Abstract in Swedish Vid många industriella processer bildas olika typer av biprodukter, som kan vara mer eller mindre giftiga. En ovarsam hantering av de giftiga ämnena, eller en olycka, kan lätt leda till att den omgivande miljön blir förorenad. Förr, när man var mindre medveten om riskerna med de här ämnena hamnade de ofta i marken kring anläggningarna. Det har resulterat i många förorenBioremediation of soils is considered a low-cost alternative to other remediation techniques. Its ability to remove a number of different pollutants has been demonstrated, relying mainly on the activities of indigenous soil bacteria. The polycyclic aromatic hydrocarbons (PAHs) are considered major environmental pollutants in soil, some of them being toxic and others carcinogenic. Since high-molecu
Popular Abstract in Swedish Blodet består av olika typer av celler med olika funktioner. De röda blodkropparna transporterar syre till alla delar av kroppen, blodplättar stoppar blödningar och en rad olika vita blodkroppar försvarar oss från olika typer av angrepp från till exempel virus eller bakterier. Generellt för alla dessa olika typer av celler är att de är kortlivade och måste ersättas kontMature blood cells are crucial for life, but they have a short lifetime and thus have to be replaced. These mature blood cells are produced by lineage restricted progenitors, which themselves are generated by rare multipotent hematopoietic stem cells (HSCs) in a highly dynamic process called hematopoiesis. In addition to the ability of HSCs to generate all blood cell lineages, they possess the uni
Aims Biogeographical evidence suggests a strong link between climate and patterns of species diversity, and climate change is known to cause range shifts. However, there is little understanding of how shifts affect community composition and we lack empirical evidence of recent impacts of climate change on the diversity of vertebrates. Using a long-term comprehensive dataset on bird abundance, we e
Estrogens contribute to the development and growth of the prostate and are implicated in prostate tumorigenesis. In their target tissues, estrogens mediate their effects via estrogen receptor alpha (ER alpha (ESR1)) and beta (ER beta (ESR2)). Hyperplasia and decreased differentiation of epithelial cells in the prostate have been reported in ER beta knockout (BERKO) mice. Herein, we studied the eff
BACKGROUND: It has been assumed that gastrin stimulates the growth of pancreatic cancer in an autocrine way through co-expression of gastrin and the cholecystokinin-B receptor (CCK-BR). However, pancreatic cancer cell lines established directly from patients have revealed a great heterogeneity in cell proliferation when exposed to CCK, gastrin and their receptor antagonists. The aim of this study
Primary headaches such as migraine and cluster headache are neurovascular disorders. Migraine is a painful, incapacitating disease that affects a large portion of the adult population with a substantial economic burden on society. The disorder is characterised by recurrent unilateral headaches, usually accompanied by nausea, vomiting, photophobia, and/or phonophobia. A number of hypothesis have em
