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Background: Huntington’s disease (HD) is a motor and cognitive neurodegenerative disorder due to prominent loss of striatal medium spiny neurons (MSNs). Cell replacement using human embryonic stem cells (hESCs) derivatives may offer new therapeutic opportunities to replace degenerated neurons and repair damaged circuits. Methods: With the aim to develop effective cell replacement for HD, we assess
Background: Induced hypothermia post-cardiac arrest is neuroprotective in animal experiments, but few high-quality studies have been performed in larger animals with human-like brains. The neuroprotective effect of postischemic hypothermia has recently been questioned in human trials. Our aim is to investigate whether hypothermia post-cardiac arrest confers a benefit compared to normothermia in la
Objective To elucidate experiences and coping strategies among adults in the surveillance of indeterminate pulmonary nodules detected with CT in the population-based Swedish CardioPulmonary bioImage Study (SCAPIS).Design A qualitative study of conventional content analysis.Settings The study was conducted at a university hospital in a southern region of Sweden. The SCAPIS setting is similar to the
ObjectivesThis study aimed to develop and externally validate a model for predicting insufficient future liver remnant (FLR) hypertrophy after portal vein embolization (PVE) based on clinical factors and radiomics of pretreatment computed tomography (CT)Patients and methodsClinical information and CT scans of 241 consecutive patients from three Swedish centers were retrospectively collected. One c
AimsRight ventricular (RV) failure causes high mortality in patients with pulmonary arterial hypertension (PAH). RV stroke work index (RVSWi) poses as a potential predictor of outcome. We evaluated how RVSWi by echocardiography (ECHO) or right heart catheterization (RHC) is altered following PAH treatment and if RVSWi is an indicator of outcome in PAH.Methods and resultsFifty-four patients with PA
Background: The perspectives of children with life-threatening or life-limiting (LT/LL) conditions have predominantly been conveyed through their parents rather than heard from the children themselves. Despite an increase in studies focusing on children’s perspectives in pediatric palliative care, this research remains limited, particularly in including children who are unable to express themselve
Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translation of drugs from animal testing to human treatments for TBI is 100%. While there are several potential explanations for this, previous clinical trials have reli
Introduction: The Person-Centred Care instrument for outpatient care (PCCoc) is a 36-item patient-reported experience measure with 4 ordered response categories, that aims to capture the degree of perceived person-centred care (PCC) from a patient perspective among persons with long-term conditions. The PCCoc is based on a framework that conceptualises outpatient PCC from lower to higher levels of
With the rapid process of urbanization, water conflicts between different water use industries and areas are increasing. Therefore, China has implemented the three-cordons system of water resources management since 2012, when how to make more reasonable regulation of water resources became an urgent problem in most areas of China. In this study, taking the Yuanhe River Basin as an example, an inte
This study examines carbon (C) and water dynamics in two East African dryland ecosystems: a savanna rangeland grazed by livestock and wildlife, and a rainfed cropland under minimal tillage. Over 185 days, both systems were showed a similar magnitude of C emissions with differing temporal patterns. The rangeland showed fluctuating C exchange, with losses followed by increased C uptake after rainfal
IntroductionThe DESOLINATION project, DEmonstration of concentrated SOLar power coupledwIth advaNced desalination system in the gulf regION, will demonstrate the efficientcoupling of a concentrated solar power (CSP) system to a membrane-based desalinationsystem at real environment. The waste heat from the CSP system will be used to drivethe membrane-based desalination processes. Therefore, the cos
PAM50 gene expression subtypes represent a cornerstone in the molecular classification of breast cancer and are included in risk prediction models to guide therapy. We aimed to illustrate the impact of included genes and biological processes on subtyping while considering a tumor’s underlying clinical subgroup defined by ER, PR, and HER2 status. To do this we used a populationrepresentative and cl
Work is central to people’s lives and the course of their life. The opportunities and chances an individual can have in their life are significantly connected to work. Individuals' work is also crucial for organisations, companies and for the whole of society. There is a constant need to make changes and readjustments of working life since these can deeply affect the individual and their employabi
The location of the Congo-São Francisco (CSF) craton, one of the largest cratons in Proterozoic paleogeography, has been poorly constrained for the supercontinent Nuna interval (ca. 1800–1300 Ma). Initial models of Nuna suggested that the CSF craton was part of the Atlantica continent, together with Amazonia, West Africa, and perhaps Río de la Plata, as a separate continental block from other Nuna
Recognizing individual differences is essential for creating inclusive and effective educational settings that support all children's learning and school success and that are considerate of their varying needs. The primary aim of this work was to help uncover some of the influencing factors and underlying dynamics that affect children’s individual educational attainment. Through brain imaging and
PAM50 gene expression subtypes represent a cornerstone in the molecular classification of breast cancer and are included in risk prediction models to guide therapy. We aimed to illustrate the impact of included genes and biological processes on subtyping while considering a tumor’s underlying clinical subgroup defined by ER, PR, and HER2 status. To do this we used a population-representative and c
BACKGROUND: Guidelines recommend measuring blood pressure (BP) in both arms, adopting the higher arm readings for diagnosis and management. Data to support this recommendation are lacking. We evaluated associations of higher and lower arm systolic BPs with diagnostic and treatment thresholds, and prognosis in hypertension, using data from the Inter-arm Blood Pressure Difference - Individual Partic
Urbanisation drives overall declines in insect pollinators. Although urban green spaces can provide suitable habitat for pollinators much remains to be learned about how urban landscapes either promote or negatively impact pollinators. We investigated how backyard design, local (100 m) and landscape (500 m) scale vegetation cover and human population density were associated with non-eusocial nativ
Clinical pain is often linked to poor body mechanics, with individuals sometimes presenting multiple painful disorders. Such disorders may be influenced by behaviors that affect the general resiliency and health of the musculoskeletal system. We aimed to develop a self-reported scale using the Malmö Diet and Cancer Study questions on work-related body mechanical exposures. An expert panel identifi
