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Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to the decrease in the quality of life, DN accounts for a large proportion of the excess mortality associated with type 1 diabetes (T1D). Whereas the degree of glycemia plays a pivo
Paleomagnetic results are presented for two Paleoproterozoic mafic dykes in the Taivalkoski area in northern Karelia Province of the Fennoscandian shield where, based on K-Ar data, the crust has seen minimal effects of the otherwise pervasive 1.8-1.9 Ga Svecofennian orogeny. Within this study a new U-Pb baddeleyite age of 2339 +/- 18 Ma has been determined for one of the E-W trending dykes (dyke A
Real-time rendering is increasingly being performed on battery powered devices, such as laptops and mobile phones. As a result, performance in rendering time is not the only important factor, but the energy consumption is also becoming more and more important, as a lower energy usage directly translates to longer battery time. The main topic of this thesis is energy consumption of graphics process
Fruit fly (Drosophila melanogaster) deoxyribonucleoside kinase (DmdNK; EC: 2.7.1.145) was characterized for its substrate specificity towards natural and non-natural nucleosides, confirming its potential in the enzymatic synthesis of modified nucleotides. DmdNK was adsorbed on a solid ion exchange support (bearing primary amino groups) achieving an expressed activity >98%. Upon cross-linking with
Background: Although both labour dystocia and domestic violence during pregnancy are associated with adverse maternal and fetal outcome, evidence in support of a possible association between experiences of domestic violence and labour dystocia is sparse. The aim of this study was to investigate whether self-reported history of violence or experienced violence during pregnancy is associated with in
This study examined age differences in phasic heart rate in response to neutral, negative and positive pictures. Heart rate changes and subjective ratings were analyzed in 22 middle-aged (40-55 years) and 30 older (56-78 years) participants. The effects of valence on the HR pattern across time were similar to that obtained by Bradley and co-workers. Conversely to previous studies, we did not repor
Regular physical activity is understood to be an essential prerequisite for human health for both psychological and physiological well-being. However, there are differences in participation in physical activity among different groups in society, and participation in physical activity can also change over a lifetime. The general aim of this thesis was to investigate how different life-change events
This paper discusses Fair Trade and analyses its impact on producers and producer organisations. Fair trade was developed in reaction to the situation on the market for conventional coffee. Coffee prices on the international market fluctuate sharply and have shown a decreasing trend. In 2001 prices reached their lowest level in 30 years. The decline in prices received by producers has increased ru
The purpose of this report is to examine whether there is any connection between the multi-storey wooden buildings, industrial construction and environmental impact. In the early 1960’s prefabricated parts were used to build “Miljonprogrammet”. This led to the streamlining of the construction process but the houses were often ill-suited for those who would live in them. Traditional building became
As a complementary product to the Tetra Brik Aseptic packaging system, Tetra Pak is about to introduce a new, value added, aseptic packaging system called SCAP. The SCAP packages consists of a lower part made of carton and an upper part made of plastic, similar to a PET-bottle, resulting in a bottle shaped package. The purpose of this thesis is to design a logistical- and material-handling system
Att företag köper upp andra företag är en viktig del av näringslivet. Det är ett sätt för företag att snabbt växa och tillskansa sig värden som gör företaget starkare. En företagsöverlåtelse är dock inte riskfri. Den är ofta kostsam och det finns inga garantier för att köpet lönar sig. Det köpande företaget kan dock till viss del skydda sin investering genom att i överlåtelseavtalet föra in en konCorporate acquisitions are a vital part of the business world. They are a way to ensure growth. They are also a good way of adding values to the company, which in turn makes the company stronger. However, an acquisition is not risk free. It is often expensive and there are no guarantees that the acquisition will be profitable in the end. The buyer can to some extent protect its investment with a n
ZnO-water nanofluid in an inner pipe was experimentally investigated to improve the thermal efficiency of double-pipe heat exchangers. In this work, a 57.6% increase in the Nusselt number was obtained at Re = 14,340 when the ZnO-water nanofluid flowed through a helically corrugated tube. It was found that helical corrugation played a more important role in heat transfer enhancement than thermophys
Background/objectives: Diet is an important factor that can exacerbate or ameliorate chronic inflammation, which has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, no prospective study has yet investigated the relation between the inflammatory potential of diet and NAFLD. The aim of this study was to investigate the association between the inflammatory po
We performed the largest genome-wide meta-analysis (GWAMA) (Max N=26,494) of the levels of 184 cardiovascular-related plasma protein levels to date and reported 592 independent loci (pQTL) associated with the level of at least one protein (1308 significant associations, median 6 per protein). We estimated that only between 8-37% of testable pQTL overlap with established expression quantitative tra
Background: With advances in clinical genetic testing, associations between genetic neurodevelopmental disorders and parkinsonism are increasingly recognized. In this review, we aimed to provide a comprehensive overview of reports on parkinsonism in genetic neurodevelopmental disorders and summarize findings related to genetic diagnosis, clinical features and proposed disease mechanisms. Methods:
Conservation programmes for endangered, long-lived and migratory species often have to target multiple life stages. The bottlenecks associated with the survival of juvenile anguillid eels migrating into inland waters, the survival and growth of the freshwater life stage, as well as the recruitment and survival of silver eels, migrating back to the ocean to spawn, must be resolved. In this study, w
In agro-ecosystems, environmental monitoring is fundamental to detect and survey changes related to land use change and management practices. Butterflies and moths have often been suggested as suitable indicators for monitoring environmental effects on biodiversity in farmlands. Here, we estimated the required sample size and monitoring effort necessary to run a Lepidoptera survey in European farm
Background: Behavioral testing provides an essential approach in further developing our understanding of brain structure and function. The aim of our study was to outline a more expanded approach to cognition- and anxiety-related behavior in the rabbit. Methods: Twenty-one 70-day old rabbits (13 female, 8 male) were exposed to open field test, dark-light box test and object recognition testing wit
1. The effects of anandamide on K+ currents and membrane potential have been examined in freshly-isolated smooth muscle cells from rat hepatic artery and the results compared with the effects of this arachidonic acid derivative on tension and membrane potential changes in segments of whole artery. 2. In the presence of 0.3 mM L-NOARG and 10 μM indomethacin, anandamide (0.1-100 μM) and endothelium-
In order to investigate whether oxidative damage is associated with differences in antioxidant intake, we measured the levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) in lymphocytes and α-tocopherol and several carotenoids in plasma of women with different dietary habits. We found that women from Granada (Spain), a region with a typically Mediterranean diet, had significantly higher leve
