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Numerical simulations coupled with LDV experiments were carried out to investigate a slot jet issued into a cross flow, which is relevant in the film cooling of gas turbine combustors. The film cooling fluid injection from slots or holes into a cross-flow produces highly complicated flow fields. In this paper, the time-averaged Navier-Stokes equations were solved on a collocated body-fitted grid s
This article outlines how conceptual spaces theory applies to modeling changes of scientific frameworks when these are treated as spatial structures rather than as linguistic entities. The theory is briefly introduced and five types of changes are presented. It is then contrasted with Michael Friedman’s neo-Kantian account that seeks to render Kuhn’s “paradigm shift” as a communicatively rational
Popular Abstract in Swedish Avhandlingens syfte är att genom en empirisk undersökning öka förståelsen av tidigt föräldraskap till barn med Downs syndrom. Jag utgår ifrån föräldrarnas livsvärld och utvecklar ett medföljande arbetssätt. Tio familjer med nyfödda barn med Downs syndrom följs genom regelbundna hembesök under det första året med barnet. Tillsammans med en medarbetare samtalar jag med föThe purpose of this dissertation was to increase - through an empirical investigation - our understanding of early parenthood in relation to children with Down syndrome. My point of departure has been the parents’ life-worlds, and I have developed an accompanying working method. Ten families with newborn infants with Down syndrome were followed through regular home visits during the first year of
Abstract in UndeterminedSubject-specific finite element models have been used to predict stress-state and fracture risk in individual patients. While many studies analysed quasi-axial loading configurations, only few works simulated sideways load configurations, such as those arising in a fall. The majority among these latter directly predicted bone strength, without assessing elastic strain predi
In marked contrast with the ideal error-free feedback assumption that is common in the literature, practical systems are likely to have severely bandwidth-limited, error-prone feedback channels. We consider the scenario where feedback from the receiver is used by the transmitter to select the best antenna, out of many available antennas, for data transmission. Feedback errors cause the transmitter
Poor survival and differentiation of grafted dopamine neurons limits the application of clinical transplantation in Parkinson’s disease. The survival of grafted dopamine neurons is only improved by a factor of 2–3 by adding neuroprotectants during tissue preparation. We used dye exclusion cell viability and electron microscopy to investigate the effects of the caspase inhibitor ac-YVAD-cmk and the
Popular Abstract in Swedish Genom att studera forna inlandsisar kan vi få en inblick i hur en inlandsis påverkar och påverkas av till exempel klimatförändringar och havsnivåvariationer i tidsperspektiv från hundratals till hundratusentals år. I Skandinavien är det framförallt spåren efter nedisningar under den senaste istiden, Weichsel-istiden, som bevarats. I den här studien fokuserar vi på ÖstIn this thesis the Weichselian glaciation history of southernmost Sweden and the southwestern Baltic Basin is discussed, with special emphasis on Middle and Late Weichselian ice advances and subsequent deglaciations. The main study area was Kriegers Flak in the southwestern Baltic Sea where pre-Late Weichselian sediments were identified. We suggest that the lowermost till on Kriegers Flak, dated t
Hyperresponsiveness and inflammation are major pathophysiological features of both allergic rhinitis and asthma. The mechanisms behind these are not fully understood. The aims of this thesis were to investigate if cytokines involved in the allergic response can induce airway hyperreactivity by affecting the airway smooth muscle directly and to identify novel mediators involved in allergic airway i
One major concern with adaptive designs, such as the sample size adjustable designs, has been the fear of inflating the type I error rate. In (Stat Med 23:1023-1038, 2004) it is however proven that when observations follow a normal distribution and the interim result show promise, meaning that the conditional power exceeds 50%, type I error rate is protected. This bound and the distributional assu
Introduction: Individuals with severe alpha-1-antitrypsin (AAT) deficiency have a well-known risk of developing emphysema but it is not known at which age the first symptoms occur and lung function declines. The aim of this study was to examine the prevalence of smoking, respiratory symptoms and lung function at the age of 30 in AAT-deficient individuals (PiZ and PiSZ) identified by neonatal scree
BACKGROUND: Development of proximal and distal colorectal cancers involve partly different mechanisms associated with the microsatellite instability (MSI) and the chromosomal instability (CIN) pathways. Colorectal cancers in patients under 50 years of age represent about 5% of the total number of tumors and have been associated with an increased frequency of MSI tumors. However, MSI and CIN may pl
During the spring of 2003 ninety-five water bodies in southeastern Estonia were surveyed for chrysophytes. The sampling was carried out as the ice broke up, when, within two weeks, the water temperature rose from 3 degrees C to 13 degrees C. Large lakes to small pools of different water chemistry were investigated. The plankton collected was studied alive within a few hours after sampling. Prepara
Purpose We investigated if early intensive care unit (ICU) scoring with the Simplified Acute Physiology Score (SAPS 3) could be improved using artificial neural networks (ANNs). Methods All first-time adult intensive care admissions in Sweden during 2009-2017 were included. A test set was set aside for validation. We trained ANNs with two hidden layers with random hyper-parameters and retained the
This paper adopts an inductive case study to examine the role of family resilience in the immigrants’ opportunity creation process. We employ family resilience (Walsh, 2002) and the opportunity creation process (Alvarez and Barney, 2007). We conducted an inductive case study on four cases of immigrant entrepreneurs who established businesses in Sweden and who have their origins in Lebanon and Syri
PURPOSE: Aortic aneurysms have a high fatality rate that could be reduced with control of risk factors and use of available screening methods for detection of early changes in aortic walls. The available data on familial risks, a potential indication for screening, are mainly limited to abdominal aortic aneurysms.METHODS: A nationwide Swedish cohort was constructed by linking the Multigeneration R
The stress response is governed by automatic neurological and hormonal processes that occur before we become consciously aware of a dangerous situation. If stress ensues for 15-30 seconds, the hormonal processes may have progressed so far that recovery takes an hour or longer instead of minutes. Stress can affect our behavior and in certain professions, such as the police force and emergency servi
The optical properties of monolayer molybdenum disulfide (MoS2)/Ag nanoparticle (NP) hybrids and their application to surface catalytic reactions were studied by transmission, photoluminescence (PL) and Raman spectroscopies. The local surface plasmon resonance (LSPR) of Ag nanoparticles was tuned to better match the exciton energy of monolayer MoS2. The PL of the hybrids was enhanced by more than
