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System Thinking is the mindset of defining and confining a problem and its symptoms as well as a method for communicating system understanding. System Analysis is taking that problem apart to understand its causalities and structural arrangement. System Dynamics is the use of the results of System Analysis in order to reconstruct the system of causalities. Modelling is used for understanding comp
Objective: To study the effects and serum levels of glibenclamide (Gb) and its active metabolites in patients on chronic Gb medication on different daily doses. Material and methods: Fifty patients with type 2 diabetes on regular Gb therapy (1.75-14.0 mg daily). Blood samples were taken immediately before and 90 min after regular Gb intake. A standardized breakfast was served 30 min after drug int
The dynamic nature of human working memory, the general-purpose system for processing continuous input, while keeping no longer externally available information active in the background, is well captured in immediate free recall of supraspan word-lists. Free recall tasks produce several benchmark memory phenomena, like the U-shaped serial position curve, reflecting enhanced memory for early and la
The development towards total offers; integrated product and service offers, is a trend in industry, particularly in business to business relations. This strive towards more extended offers can be noticed in a wide range of companies from different branches, and it has important implications on management. Today there is no established method available to handle the extended risks associated with
Abstract Work on the design, synthesis, and biological evaluation of galectin inhibitors is presented. The most significant results relate to the development of galactose-based arginine “tweezers” and taloside-based galectin inhibitors. The galectins are a β-galactoside binding protein family. They are involved in cancer and inflammation, thus comprising interesting pharmaceutical targets. Galact
The walrus (Odobenus rosmarus) is in some current systematic schemes divided into three subspecies: O. r. rosmarus in the North Atlantic, O. r. divergens in the North Pacific and O. r. laptevi in the Laptev Sea. These three subspecies have been described as differing in body size, but the taxonomic status of O. r. laptevi is disputed. The current study applies molecular and morphometric methods to
Timber structures and wooden element are in general affected by moisture and moisture variation in different ways. Their hygroscopic properties result in adsorption of water when wetted and in desorption when dried. Because the volume of wood is not constant but varies with the moisture content, uneven distribution of moisture will result in induced eigen-stresses because of internal restraint hyg
Specific parameters of the neuronal tissue microstructure, such as axonal diameters, membrane permeability and intracellular water fractions are assessable using diffusion MRI. These parameters are commonly estimated using analytical models, which may introduce bias in the estimated parameters due to the approximations made when deriving the models. As an alternative to using analytical models, a
Den svenska lagen på upphandlingsområdet för den klassiska sektorn, lagen om offentlig upphandling (LOU), bygger på upphandlingsdirektiv grundande på EU-fördragets bestämmelser om fri rörlighet för varor och tjänster. Rättsmedelsdirektivet, direktiv 89/665/EEG, som syftar till att säkerställa efterlevanden av upphandlingsreglerna, tillkom i början av 90-talet. Direktivet lämnade dock stort utrymmeThe Swedish law on procurement is based on Community Directives on public procurement establishing fundamental EU Treaty principles such as the principles of free movement of goods and services. The Remedies Directive (89/665/EEC), entering into force in the beginning of the 90´s, was adopted to ensure that effective and rapid remedies are available to aggrieved bidders. However, the directive let
State-sponsored cyber groups have long utilized spear phishing to pierce government networks. Spear phishing relies on social engineering to trick individuals into revealing sensitive information or downloading malicious software, rather than hacking into a system vulnerability by force. While email remains the preferred medium to conduct spear phishing attacks, social m
New Information Systems Development Methodologies (ISDMs) are suggested in the belief that their deployment would be beneficial to consultants in their work. A large number of ISDMs already exist but their value has been questioned and at the same time new methodologies continue to be introduced in an attempt to support and improve the practice of information systems development work. What is not
One of the basic principles of Swedish law is that everyone is entitled to have his/her claims determined by a court and that the judgment should be given after a hearing. The main rule is that the plaintiff can claim whatever he/she wants, even if it seems absurd. This is a right also given by the European Convention of the human rights article 6:1, which says that everyone is entitled to a publi
Biodegradation rate is an important index to evaluate the environmental risk of chemicals, which is usually determined by measuring oxygen consumption through respirometer in a biodegradation test. However, atmospheric pressure variations affect reactor oxygen concentration and oxygen volume recorded by respirometer in biodegradation test, and the parameters of reactor volume and test material amo
With the vast amount of data available, and its increasing complexity in manufacturing processes, traditional statistical approaches have started to fall short. This is where machine learning plays a key role, addressing the challenges by bringing the ability to analyse large and complex datasets from multiple sources, finding non-linear and intricate patterns on data, relationships between severa
In this study an algorithm was developed for calculating maximum detectable distance (MDD) for mobile gamma-ray detection of lost sources in-situ for some common mobile spectrometer systems and gamma sources (137Cs and 60Co). The MDD is a function of detector efficiency, vehicle speed, acquisition time interval, radiation background level and accepted frequency of false alarms. To test its accurac
Objective: Cognitive workload monitoring (CWM) can enhance human-machine interaction by supporting task execution assistance considering the operators cognitive state. Therefore, we propose a machine learning design methodology and a data processing strategy to enable CWM on resource-constrained wearable devices. Methods: Our CWM solution is built upon edge computing on a simple wearable system, w
Core-shell nanoparticles have gathered much attention of the scientific community owing to their potential applications in various fields including biomedical imaging and catalysis. Predicting core-shell preference1-3 is, however, still largely based on a few experimental observations and limited theorical studies, and hence development of new core-shell nanoparticles is normally built on a trial-
Despite the availability of methods for analyzing protein complexes, systematic analysis of complexes under multiple conditions remains challenging. Approaches based on biochemical fractionation of intact, native complexes and correlation of protein profiles have shown promise. However, most approaches for interpreting cofractionation datasets to yield complex composition and rearrangements betwee
The Millennium Development Goals (MDGs) were an important precursor to the Sustainable Development Goals (SDGs). Hence, identifying the conditions that made the MDGs successful enhances our understanding of global goal-setting and informs the global endeavour to achieve the SDGs. Drawing on a comprehensive review of 316 articles published between 2009 and 2018, we identify six factors that have en
