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Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis
Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe
Potentialities of manganese ore and iron-carbon particles for pharmaceuticals and personal care products removal in electroactive constructed wetland
This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo
Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome
INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w
Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology
Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi
The Playing Field for Change: Exploring Football as a Social Intervention in Recovery and Reintegration
Lær dansk online!
https://www.css.lu.se/article/laer-dansk-online/ - 2026-04-27
Energy Storage & Conversion
Sustainable energy storage and conversion explores innovative methods to efficiently store and transform energy from various renewable sources. It focuses on technologies like advanced batteries, hydrogen production, fuel cells, and thermochemical systems as well as safety aspects of battery storage systems. Research aims to enhance energy density, reduce costs, and improve scalability, enabling r
https://www.energy.lth.se/research/energy-storage-conversion - 2026-04-29
Finansieringsmetoder-for-excellens
Checklista för uppdragsavtal Forskningsservice Sophie Hydén Picasso Finansieringsmetoder för excellens PLANERA EN AKADEMISK KARRIÄR En akademisk karriär är ofta mångfacetterad, och dess olika delar ställer krav på olika typer av egenskaper och färdigheter. Olika karriärprofiler och vägar framåt kan överlappa och kombineras, alternativt så rör man sig mer etappvis längst karriärvägen. Forskning, un
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/finansieringsmetoder-for-excellens.pdf - 2026-04-30
The myth of ACGN nationalism in China : animation, audiences, and nationalism
Monte Carlo simulations of a clay inspired model suspension: the role of rim charge
We present a theoretical investigation of a model clay dispersion in 1-1 salt solutions by varying the particle volume fraction and ionic strength as well as the charge distribution on the clay platelets. The platelets are modeled as discs with charged sites distributed on a hexagonal lattice. The edge sites can be positively charged while the remaining sites are negative giving rise to a strong c
Evolutionary and functional studies of protein H: a surface molecule of Streptococcus pyogenes
Popular Abstract in Swedish Protein H - ett bakteriellt ytprotein med förmåga att binda till olika proteiner hos människa Bakgrund I vårt dagliga liv omges vi av bakterier av många olika slag. Flertalet av dessa är normalt ofarliga och många utgör den så kallade normalfloran hos människa. En del bakterier kan under vissa förhållanden ge upphov till infektion och sjukdom, men för att åstadkomma d
Disputation och examen externa antagna doktorander lucris 2016
Brevmall Konstnär l iga fakulteten i Malmö Disputation och examen inom forskarutbildning Denna guide är framtagen som stöd under disputationsprocessen för doktorander antagna enligt särskild överenskommelse om forskarutbildning mellan Konstnärliga fakulteten, Lunds universitet och - doktorander som antagits inom Konstnärliga forskarskolans (KF) ram, - doktorander i musikpedagogik vid Kungl. Musikh
Dosing regimens, FVIII levels and estimated haemostatic protection with special focus on rFVIIIFc.
Disputation och examen externa antagna doktorander lucris 2017
Brevmall 1 Konstnärliga fakulteten i Malmö Disputation och examen inom forskarutbildning Denna guide är framtagen som stöd under disputationsprocessen för doktorander antagna enligt särskild överenskommelse om forskarutbildning mellan Konstnärliga fakulteten, Lunds universitet och - doktorander som antagits inom Konstnärliga forskarskolans (KF) ram, - doktorander i musikpedagogik vid Kungl. Musikh
Anti-herpes simplex type 1 activity in IgG subclasses produced systemically and intrathecally in patients with herpes encephalitis
High Affinity Antibodies to Plasmodium falciparum Merozoite Antigens Are Associated with Protection from Malaria
Background: Malaria kills almost 1 million people every year, but the mechanisms behind protective immunity against the disease are still largely unknown. Methodology/Principal Findings: In this study, surface plasmon resonance technology was used to evaluate the affinity (measured as kd) of naturally acquired antibodies to the Plasmodium falciparum antigens MSP2 and AMA1. Antibodies in serum samp
Proteolysis of purified IgGs by human and bacterial enzymes in vitro and the detection of specific proteolytic fragments of endogenous IgG in rheumatoid synovial fluid
A comparative in vitro survey of physiologically relevant human and microbial proteinases defined a number of enzymes that induced specific hinge domain cleavage in human IgG1. Several of these proteinases have been associated with tumor growth, inflammation, and infection. A majority of the identified proteinases converted IgG to F(ab')(2), and a consistent feature of their action was a transient
A Heterobimetallic FeIIIMnII Complex of an Unsymmetrical Dinucleating Ligand: A Structural and Functional Model Complex for the Active Site of Purple Acid Phosphatase of Sweet Potato
The heterodinuclear mixed-valence complex [FeMn(ICIMP)(OAc)(2)Cl] (1) {H2ICIMP = 2-(N-carboxylmethyl)-[N-(N-methylimidazolyl-2-methyl)aminomethyl]-[6-(N-isopropylmethyl)-[N-(N-methylimidazolyl-2-methyl)]aminomethyl-4-methylphenol], an unsymmetrical N4O2 donor ligand} has been synthesized and fully characterized by several spectroscopic techniques as well as by X-ray crystallography. The crystal st
Intercomparison of C-14 Analysis of Carbonaceous Aerosols: Exercise 2009
Radiocarbon analysis of the carbonaceous aerosol allows an apportionment of fossil and non-fossil sources of airborne particulate matter (PM). A chemical separation of total carbon (TC) into its subfractions organic carbon (OC) and elemental carbon (EC) refines this powerful technique, as OC and EC originate from different sources and undergo different processes in the atmosphere. Although C-14 an
