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Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The most widespread underlying genetic deficiency is a heterozygous deficiency of the serine protease inhibitor Cl esterase inhibitor (C1-Inh). In addition to low C4 levels, the most important laboratory parameter for correct diagnosis of HAE or angioedema du

Popular Abstract in Swedish Kring familjeproblematiken och för behandlingen av familjekonflikter har det svenska samhället organiserat olika sociala verksamheter som traditionellt regleras av Socialtjänstlagen. Familjerådgivningen är en av dessa verksamheter och definieras som en psykoterapeutisk behandling, till vilken en eller båda parter vänder sig oftast på frivillig basis när de upplever att

Objective: Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men. Design: Community-based, cross-sectional study of 3369 men aged 40-79 years. Methods: Cognition tests were the Rey-Osterrieth Complex Figure, Camden Topo

Antikroppar har ett brett användningsområde med stor potential men det är svårt att skapa stabila lösningar. Den strukturella stabiliteten är en viktig faktor när man väljer läkemedelskandidater, och i de tidiga utvecklingsstadierna görs prediktiva undersökningar för att ta reda på varje kandidats stabilitet och utvecklings-potential. Därmed är det av största intresse att utvärdera hur antikropparA great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. The stability of the candidates can be estimated using different orthogonal techniques and the aim of this investigation was thus to use orthogonal techniques for the investigation of conformationa

Questions about institutional stability and change are critically important for any understanding of political institutions. The field of Historical institutionalism in political science has described, studied and theorized institutions for decades. One of the most recurring concepts utilized in the explanation of institutional stability is path dependence, describing theoretical and empirical mec

The spontaneous open-field behavioural effects of 10 days of chronic treatment with two clinical doses (10 and 20 mg/kg daily) and one high/toxic dose (100 mg/kg daily) of the selective serotonin reuptake inhibitor citalopram (delivered subcutaneously by implanted osmotic pumps) were examined in rats. Central and peripheral arena locomotor and rearing activities were recorded simultaneously, and t