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Protein homeostasis in cells, proteostasis, is maintained through several integrated processes and pathways and its dysregulation may mediate pathology in many diseases including Duchenne muscular dystrophy (DMD). Oxidative stress, heat shock proteins, endoplasmic reticulum (ER) stress and its response, i.e. unfolded protein response (UPR), play key roles in proteostasis but their involvement in t

Autoantibody-mediated diseases comprise a heterogeneous group of disorders in which the pathogenic potential of autoantibodies has been clearly demonstrated. In general, their treatment relies on the long-term use of systemic corticosteroids and other immunosuppressants that are associated with considerable adverse reactions. EndoS, an endoglycosidase derived from Streptococcus pyogenes, specifica

Fluxes of methane, CH4, were measured with the eddy covariance (EC) method at a small boreal lake in Sweden. The mean CH4 flux during the growing season of 2013 was 20.1 nmol m−2 s−1 and the median flux was 16 nmol m−2 s−1 (corresponding to 1.7 mmol m−2 d−1 and 1.4 mmol m−2 d−1). Monthly mean values of CH4 flux measured with the EC method were compared with fluxes measured with floating chambers (

https://www.cec.lu.se/sites/cec.lu.se/files/2022-03/Adm%20Guide%202022%20English%20v2.xlsx - 2026-07-19

The goal of this study is to investigate the applicability of asymmetrical flow field-flow fractionation (AsFlFFF)–multi angle laser light scattering (MALLS), and to develop a method for analysis of cationic potato amylopectin (CPAP) having ultrahigh molecular mass (UHMr). Use of the aqueous carrier having low salt content (3 mM NaN3) resulted in a distortion in AsFlFFF fractograms of CPAP with a

Background and purpose: Cone Beam Computed Tomography (CBCT) based online adaptive radiotherapy (oART) has been clinically implemented for several anatomical sites worldwide. However, random and abrupt anatomical changes with large density alterations can occur in lung patients, leading to uncertainties with synthetic computed tomography (sCT) and dose calculation. The anatomical changes could be

Vid en gäldenärs insolvens fungerar konkursinstitutet som ett fördelningsinstrument av dennes tillgångar. Konkurrerande betalningsanspråk hos borgenärerna kommer att tvångsvis rangordnas efter sin karaktär. Förmånsrättslagen SFS 1970:979. spelar härvid en framträdande roll. Genom möjligheten till återvinning av betalning och andra rättshandlingar gjorda inom en viss kritisk tidsrymd före konkursan

Purpose: The purpose of this thesis is to create an integrative understanding of how OBCs are fostered by developing a framework for strategic implementation. Methodology: The chosen method is of an explorative nature with an abductive approach. The authors will develop an integrated OBC framework by synthesising relevant brand community literature. This OBC framework will then be scrutinized by e

The internet has had an impact on public relations that goes well beyond significant adjustments in practice made in response to technological change. Mirroring the emergence of ”Web 2.0” platforms, the discipline is increasingly articulating its purpose and culture through discourse associated with social media. Concepts such as transparency, authenticity, conversation and engagement can be inext

This study introduces a corpus of 260 naturalistic human nonlinguistic vocalizations representing nine emotions: amusement, anger, disgust, effort, fear, joy, pain, pleasure, and sadness. The recognition accuracy in a rating task varied greatly per emotion, from <40% for joy and pain, to >70% for amusement, pleasure, fear, and sadness. In contrast, the raters’ linguistic–cultural group had no effe