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Abstract: The influence of brain ischemia on the subcellular distribution and activity of Ca2+/calmodulin‐dependent protein kinase II (CaM kinase II) was studied in various cortical rat brain regions during and after cerebral ischemia. Total CaM kinase II immunoreactivity (IR) and calmodulin binding in the crude synaptosomal fraction of all regions studied increase but decrease in the microsomal a
Abstract: Casein kinase II (CKII) is a protein kinase acting in the intracellular cascade of reactions activated by growth factor receptors, and that has a profound influence on cell proliferation and survival. In this investigation, we studied the changes in the activity and levels of CKII in the rat brain exposed to 10. 15 and 20 min of transient forebrain ischemia followed by variable periods
A brief period of sublethal cerebral ischemia, followed by several days of recovery, renders the brain resistant to a subsequent lethal ischemic insult, a phenomenon termed ischemic preconditioning or tolerance. Ischemic tolerance was established in the rat two-vessel occlusion model of ischemia, induced by occlusion of both carotid arteries in combination with hypotension. Ischemic preconditionin
A short period of sublethal preconditioning ischemia (3 min) followed by two days of reperfusion provides almost complete protection against ischemic cell death induced by a second (9 min) lethal ischemic episode. Here, we have investigated the extracellular signal-regulated protein kinase kinase and extracellular signal-regulated protein kinase, two kinases known to activate gene transcription an
A brief, 3 min period of global forebrain ischemia in the rat, induced by bilateral common carotid occlusion combined with hypotension, confers resistance to hippocampal pyramidal neurons against a subsequent 10 min ischemia, which is normally lethal to these cells. The molecular mechanisms underlying this ischemic preconditioning, or tolerance, are poorly understood. The tumor suppressor p53 is a
The changes in extracellular Ca2+ (Cae) and K+ (Ke) activities were studied in the rat brain during insulin-induced hypoglycemia. At about the time of onset of isoelectric EEG in severe insulin-induced hypoglycemia (300-g male Wistar rats under 70% N2O anaesthesia), there was an increase in Ke which, at ∼13 mM, was associated with a fall in Cae. Ke peaked at 48 ± 12 mM, and Cae at 0.18 ± 0.28 mM.
The protective effect of the α2-receptor antagonist idazoxan against neuronal damage in the neocortex and in the hippocampal CA1 region was studied in rats exposed to 10 min of incomplete forebrain ischemia. When administered i.v. immediately after ischemia (0.1 mg/kg) and subsequently for 6 h (10 μg/kg/min), idazoxan significantly reduced neuronal damage in the hippocampus (from 84 to 26%) and in
Next generation targeted sequencing of HLA-DRB1, -DRB3, -DRB4 and -DRB5 (abbreviated as DRB345) provides high resolution of functional variant positions to investigate their associations with type 1 diabetes risk and with autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 (ZnT8A). To overcome exceptional DR sequence complexity due to high polymorphisms and extended linkage-di
Background: Proton beam therapy (PBT) offers dosimetric advantages in pediatric radiotherapy by reducing radiation exposure to healthy tissues. However, broad implementation raises important ethical, logistical, and equity considerations, especially in settings with limited access to advanced technologies. Procedure: This position paper by the Paediatric Radiation Oncology Society (PROS) reviews t
The paper analyses the legal framework for the collection and distribution of remote sensing data, particularly in the field of sustainable development and environmental protection at the European level. The research firstly focuses on the historical evolution of space law at the international, European, and national levels, starting from the 1970s. In parallel, environmental law has rapidly devel
A search is performed for dark matter particles produced in association with a resonantly produced pair of (Formula presented)-quarks with (Formula presented) using (Formula presented) of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector at the LHC. This signature is expected in extensions of the standard model predicting the production of dark matter par
A search for T and Y vector-like quarks produced in proton-proton collisions at a centre-of-mass energy of 13 TeV and decaying into Wb in the fully hadronic final state is presented. The search uses 139 fb−1 of data collected by the ATLAS detector at the LHC from 2015 to 2018. The final state is characterised by a hadronically decaying W boson with large Lorentz boost and a b-tagged jet, which are
The anticipated climate changes are predicted to alter the precipitation patterns in Sweden. Increased episodes of intense short-duration rainfall and higher intensities of day long-duration rainfall are expected. Road sections are often a target of flooding, causing impassable roads, due to the lack of capacity of drainage systems. One of the factors determining the water flow to a depression is
A search for R-parity-conserving supersymmetry in events with large missing transverse momentum, jets and at least one hadronically decaying τ-lepton is presented. Both gluino and squark pair production are considered, with the cascade decay of each gluino or squark producing either a τ-slepton or a τ-sneutrino. Three channels are examined, requiring either exactly one hadronically decaying τ-lept
PowerPoint-presentation 2019-05-29 1 Hjärnligen Neurologiska Kliniken-Lund Skånes universitetssjukhus Huntingstons sjukdom Symtom och nuvarande behandlingar Håkan Widner Professor, överläkare Neurologiska kliniken Skånes universitetssjukhus hakan.widner@skane.se Hjärnligen Neurologiska Kliniken-Lund Skånes universitetssjukhus Behandlingar Kunskap Strategier Läkemedel Behandlingar – träning – kost-
https://www.huntington-research.lu.se/sites/huntington-research.lu.se/files/symtom_och_behandlingar.pdf - 2026-07-21
Konsthögskolans galleri, KHM2, Bergsgatan 29, 3 våning Kontakta Sophie eller respektive tekniker om utrustning du vill låna. Kontakta Kristian i god tid för att planera transporten till lokalen. Samtransport från Khm till Galleriet och lastning av föregående utställningar för tillbakatransport till Khm, på måndag f.m. För att få tillträde till byggnaden, hissen och gallerirummet måste du ha ett LU
https://www.khm.lu.se/sites/khm.lu.se/files/infogallerikhm2svenska.pdf - 2026-07-21
Microsoft Word - ECOSIMP verktyg för EbA.2019-04-16.docx Författare: Christine Wamsler och Ebba Brink Lunds universitets centrum för samhällsuthålliga studier (LUCSUS), Lund, Sweden University College London (UCL) Hazard Centre – Disaster Studies and Management Working Paper No. 32, September 2016 Integrering av ekosystembaserad klimatanpassning (EbA) i kommunal verksamhet och planering EN GUIDE F
Universitetsgemensamma medel Ansökan om finansiering av forskningsinfrastruktur från universitetsgemensamma medel Ansökan ska skrivas på engelska. Punkterna 1-14 får omfatta max 5 sidor exklusive budgettabeller. Använd 12 pt och Times New Roman. Alla delar av ansökan (inklusive bilagor) ska sammanfogas till ett sökbart PDF-dokument med filnamn efter huvudsökande, t ex nn.pdf. 1. Titel ( Title ) 2.
