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Liquid crystalline nanoparticles (LCNPs), e.g. cubosomes and hexosomes, are receiving more and more attraction as drug delivery vehicles. Dry powder formulation that forms LCNPs upon hydration can be advantageous to make new routes of administration accessible. In this work, we investigate use of three disaccharides (lactose, trehalose and sucrose) as protective matrices for glycerol monooleate ba
The coefficient of friction (COF) and wear are critical parameters in assessing disc brake performance. However, their study is challenging due to their interdependence on contact pressure, sliding velocity, temperature, and material composition. The complex contact interactions between brake pads and discs involve the continuous formation and destruction of mesoscopic contact plateaus, which
Software is at the core of digitalisation and is often claimed to play a central role in innovation and in shaping competition across industries and firms. There are yet few studies of the extent and nature of software development across firms. We employ a unique firm-level survey comprising 3,929 firms across Sweden to analyse the distribution and characteristics of firms that invest in software
On the 4th of July 2024 the Swedish government decided to assign the Agency for Digital Government and the Swedish Authority for Privacy Protection to give guidelines for increasing use of generative artificial intelligence in the public sector. One year later, on the 10th of September 2025, the government released their budget proposition for the year 2026. Here the National Archives of Sweden (N
Denna studie undersöker hur olika grader av gränssnittsanpassning i smarttelefoner påverkar seniorers upplevelse med avseende på mental ansträngning, självständighet och social acceptans. Studien genomfördes med en kvalitativ metod där fem respondenter vid minst 67 års ålder utförde praktiska arbetsuppgifter på tre smarttelefoner med varierande anpassningsnivåer: en icke-anpassad, en mjukvaruanpas
Bakgrund: Svårigheter med sensorisk modulering är vanligt förekommande vid psykisk ohälsa och kan medföra olika negativa effekter i vardagen. Inom dagens psykiatri fokuseras det på personlig återhämtning inom rehabiliteringsinsatser, där man bl.a. fokuserar på att skapa ett meningsfullt liv för individen trots sin psykiska ohälsa. Den arbetsterapeutiska interventionen Sensory Awareness Program (SA
I denna studie undersöker vi upplevelser och effekter av vårt eget nyskrivna metodmaterial för körer. Tidigare forskning har visat att många körer idag ger uttryck för restriktiva könsnormer vilket gör verksamheten mindre inkluderande för de som bryter mot dessa normer, särskilt transpersoner. Vi har därför konstruerat ett metodmaterial med syfte att tillgängliggöra normkritiskt och normkreativt aIn this study, we investigate the experiences and effects of our own original pedagogical material for choirs. Previous research has shown that many choirs today still hold onto restrictive gender norms that make the activity less inclusive for people who do not fit into these norms, especially transgender people. We have therefore constructed a pedagogical material with the aim of making norm-cri
Small interfering RNAs (siRNAs) are a rapidly growing class of oligonucleotide therapeutics that modulate gene expression by inducing targeted mRNA degradation. siRNAs are potent and their effect is long-lasting, making them promising candidates for chronic neurodegenerative disease. However, siRNAs can elicit both on- and off-target toxicity, and while acute neurotoxicity has been characterized,
Objectives To investigate how patients undergoing allo-HCT experience preparedness for self-care and the transition to post-hospital recovery, after using the Assessment of Rehabilitation Needs Checklist (ARNC) in combination with a conversation in a nurse-led intervention. Methods Patients were recruited between March and September 2023, at two allo-HCT centres in Sweden. A convergent parallel mi
Despite generous welfare and family policies, Sweden has a sizeable positive socioeconomic gradient in fertility; those with higher incomes have more children than those with lower incomes. While this positive socioeconomic gradient in fertility is not a new phenomenon in Sweden, a similar shift towards a positive fertility gradient is more recently seen in other high-income countries as well. Amo
The contemporary crisis of public discourse is routinely misdiagnosed as a post-truth disregard for facts. This presentation argues that the deeper pathology is a hyper-eikotic environment: a flood of weaponised plausibilities resulting from the historical schism between demonstrable evidence and persuasive reasoning. To navigate this environment, citizens and critics need more than factchecking;
Byggsektorn står för en betydande del av Sveriges resursförbrukning och klimatpåverkan, vilket gör omställningen till en cirkulär ekonomi central för att nå miljö- och klimatmål. Arkitekten har en nyckelroll i denna omställning eftersom många avgörande beslut om materialval, bevarande och byggnaders livscykel fattas i de tidiga projektskeden. Samtidigt är det oklart hur arkitekter i Sverige faktThe construction sector in Sweden accounts for a significant share of resource use and climate impact, making circular economy a key strategy for reducing waste and achieving sustainability goals. This thesis investigates swedish architects and their role in promoting circular construction in Sweden, focusing on strategies, barriers, and opportunities. The study applies a qualitative method based
The aim of this study was to evaluate the performance of an artificial intelligence (AI)-based method for automated segmentation of total metabolic tumor volume (TMTV) in 18F-FDG PET/CT scans of patients with lymphoma, using an independent, publicly available benchmark dataset curated and segmented by expert readers in a previously published study. Methods: The AI model, based on a 3-dimensional U
Most retrograde signalling research in plants was performed using Arabidopsis, so an evolutionary perspective on mitochondrial retrograde regulation (MRR) is largely missing. Here, we used phylogenetics to track the evolutionary origins of factors involved in plant MRR. In all cases, the gene families can be traced to ancestral green algae or earlier. However, the specific subfamilies containing f
Background: Optimal reconstruction of the perineal defect after extended abdominoperineal excision remains uncertain, and randomized comparisons between biological mesh and myocutaneous flaps are lacking. This trial assessed whether an acellular porcine collagen implant (APCI) is non-inferior to a gluteus maximus myocutaneous flap (GMF) for pelvic floor reconstruction. Methods: NEAPE was a multice
Polysaccharide degradation by microorganisms is essential in driving global nutrient cycling, developing renewable fuels or chemicals, and promoting human gut health. However, complex polysaccharides are often insoluble, making it challenging to study degradation with soluble enzymes or to measure microbial growth. Several protocols exist to address this challenge, including 3D-printed biomass con
This thesis explores possibilities and challenges for urban planners to contribute to a degrowth transformation. Degrowth calls for a reduction of production and consumption, a redistribution of wealth and a shift in societal norms and values to address the current environmental crises. According to the existing literature, urban planners may be able to help advance and implement degrowth. To expl
Adrenal incidentalomas are seen in about five percent of abdominal CT examinations, and in most cases represent non-hormone-producing adrenocortical adenomas, but hormone-producing or malignant lesions occur. Revised Swedish guidelines for the evaluation and management of adrenal incidentalomas based on recently published European guidelines are presented. The importance of a thorough radiological
Objective To establish which risk factors are predictive for sudden death in hypertrophic cardiomyopathy (HCM) diagnosed in childhood. Methods A Swedish national cohort of patients with HCM diagnosed <19 years of age was collected between 1972 and 2014, consisting of 155 patients with available ECGs, with average follow-up of 10.9±(SD 9.0) years, out of whom 32 had suffered sudden death or cardiac
