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Objectives. Guidelines of the European Society of Cardiology (ESC) recommend that ferritin and transferrin saturation should be tested in chronic heart failure (HF) and state that iron treatment with ferric carboxymaltose should be considered in HF patients with iron deficiency to alleviate symptoms and improve exercise tolerance and quality of life. This study evaluates the cost effectiveness of

Date palm oases in North Africa have historically supported agriculture through indigenous irrigation techniques such as foggaras and tabias, made possible by a relatively stable water supply. However, the sustainability of these systems is increasingly threatened by irrational water use, climate change and environmental resources degradation. In response to these challenges, we introduced and eva

The effects of possible climate changes on a cold attic performance are considered in this work. The hygro-thermal responses of the attic to different climate data conditions are simulated using a numerical model, which has been made using the IBPT. Cold attic, which is the most exposed part of the building to the environment, is classified as a risky construction in Sweden. Mould growth on intern

Accurate reservoir dynamics, particularly water storage and inflow, are crucial for release decisions and operation rule assessments. However, the lack of sufficient monitoring data has hindered the accurate representation of reservoir behavior in hydrological models. While the increasing availability of satellite imagery provides unprecedented opportunities for dynamic reservoir monitoring, its p

While a naive algorithm for multiplying two 2 × 2 matrices requires eight multiplications and four additions, Strassen showed how to compute the same matrix product using seven multiplications and 18 additions. Winograd reduced the number of additions to 15, which was assumed to be optimal. However, by introducing a change of basis, Karstadt and Schwartz showed how to lower the number of additions

Objectives: Our aim was to compare direct costs for single pill combinations (SPCs) and free-drug combinations for hypertension treatment. Methods: We focused on Australia as a case study and reviewed total costs, and for the patient and government. We reviewed the Australian “Pharmaceutical Benefits Scheme item drug map” considering different thresholds for the government safety net. Total costs

The paper is a keynote talk, introducing the problem with texts that are not finished - or maybe not even written at all but - but still haunts the imagination of the writer, specifically the creative writing student.

Background: The role of cystectomy in synchronous oligometastatic bladder cancer is unclear. Objective: To describe a population-based consecutive cohort with primary oligometastatic bladder cancer (M1a or M1b) treated with curative intent. Methods: Twenty consecutive patients with primary stage M1a or M1b bladder cancer subjected to induction chemotherapy and radical cystectomy 2013–2024 in the S

Purpose: To define the curriculum content for two interactive learning courses on age-related macular degeneration (AMD): (1) an advanced course tailored for general ophthalmologists and (2) a basic course for non-ophthalmologist healthcare staff. This initiative aims to establish a national consensus on the educational framework for AMD management among general ophthalmologists in Denmark. Method

Few existing studies have delved into individual-level attitudes towards the exchange of sexual services for payment, leaving a significant gap in our understanding. Various studies have speculated about how certain demographic factors and attitudes may shape people's perceptions of causes and consequences relating to such exchanges, but none have directly investigated this topic. To bridge this g

Background: Neoadjuvant cisplatin-based combination chemotherapy (NAC) is standard perioperative treatment of patients with muscle-invasive urothelial bladder cancer (MIBC); however, about half of the patients experience recurrence of the disease. Biomarkers for response and survival represent an unmet medical need. We used tumor specimens from transurethral resections of the bladder to explore ge

A transcriptional reporter fusion has been introduced into the chromosomal ftsZ locus in such a way that all transcription that normally reaches ftsZ can be monitored. The new Φ(ftsZ-lacZ) fusion yields four times more β-galactosidase activity than a ddlB-ftsQAZ-lacZ fusion on a lambda prophage vector. A strongly polar ddlB::Ω insertion prevents contributions from signals upstream of the ftsQAZ pr

Background and purpose: The study aims to evaluate dosimetric properties of hypofractionated treatment plans integrating focal boost, using registered whole-mount histopathology (WMHP) as reference standard. Methods: Fifteen men from the PAMP trial (EudraCT: 2015-005046-55) were included. Participants had ≥ 1 ISUP Grade group ≥ 4 lesion and underwent [68Ga]prostate-specific membrane antigen (PSMA)

This study introduces the concept of Collective Permanent Supportive Housing (CPSH), tailored for older adults with histories of homelessness and long-term substance use. CPSH offers residents individual apartments and secure tenures, using a harm reduction approach. The study, being designed to identify the benefits and risks of CPSH, was based on (i) a quantitative dataset with a national survey

We present the CH4 and N2O budgets for anthropogenic and natural sources and sinks of Australasia (Australia and New Zealand) from 2010 to 2019 using bottom-up and top-down methods, in line with the RECCAP-2 initiative, with extensions to 2022. We show that the bottom-up CH4 budget for Australasia (2010–2019) was a net source of 14.1 ± 5.5 Tg CH4 yr−1, with Australia and New Zealand contributing 8

Background: Minimising time from injury to hospital admission is considered a key factor in trauma. Trauma care is often centralised to hospitals, which, because of their urban location, make treatment more accessible to patients in densely populated areas. If prehospital time increases with declining population density, an effect on mortality could hence be present. The primary aim of this study