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BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are persistent substances with surfactant and repellent properties. Municipal drinking water contaminated with PFAS had been distributed for decades to one third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from December 16, 2013.AIMS: The purpose was
BACKGROUND: Screening immigrant mothers for postpartum depression has been shown to be challenging for health care professionals in handling cultural implications of postpartum depression, communicating through interpreter and applying translated versions of the screening scale.AIM: The aim of the study was to test the feasibility of an evidence-based educational intervention for Child Health Serv
Assessing the causal effects of individual dietary macronutrients and cardiometabolic disease is challenging owing to the complexity to distinguish direct effects from those mediated or confounded by other factors. To estimate these effects, intake of protein, carbohydrate, sugar, fat, and its subtypes were obtained using food frequency data derived from a Swedish population-based cohort (n~60,000
There is a large interest in predicting high-pressure homogenizer (HPH) valve hydrodynamics using CFD, in academic research and industrial R&D. Most of these studies still use two-equation RANS turbulence models, whereas only a few have used LES formulations. From a theoretical perspective, LES is known to be more accurate than RANS, especially in terms of estimating the dissipation rate of tuThere is a large interest in predicting high-pressure homogenizer (HPH) valve hydrodynamics using CFD, in academic research and industrial R&D. Most of these studies still use two-equation RANS turbulence models, whereas only a few have used LES formulations. From a theoretical perspective, LES is known to be more accurate than RANS, especially in terms of estimating the dissipation rate of tu
Using multilayer zone plates (MZPs) as two-dimensional optics, focal spot sizes of less than 10 nm can be achieved, as we show here with a focus of 8.4 nm × 9.6 nm, but the need for order-sorting apertures prohibits practical working distances. To overcome this issue, here an off-axis illumination of a circular MZP is introduced to trade off between working distance and focal spot size. By this, t
Purpose: The application of automated image analyses could improve and facilitate standardization and consistency of quantification in [18F]DCFPyL (PSMA) PET/CT scans. In the current study, we analytically validated aPROMISE, a software as a medical device that segments organs in low-dose CT images with deep learning, and subsequently detects and quantifies potential pathological lesions in PSMA P
The prevalence of type 2 diabetes (T2D) is increasing worldwide, but current treatments have limitations. miRNAs may play a key role in the development of T2D and can be targets for novel therapies. Here, we examined whether T2D is associated with altered expression and DNA methylation of miRNAs using adipose tissue from 14 monozygotic twin pairs discordant for T2D. Four members each of the miR-30
Background: Radical prostatectomy reduces mortality among patients with localised prostate cancer. Evidence on whether different surgical techniques can affect mortality rates is lacking. Objective: To evaluate functional and oncological outcomes 8 yr after robot-assisted laparoscopic prostatectomy (RALP) and open retropubic radical prostatectomy (RRP). Design, setting, and participants: We enroll
Background and aims: Ethnicity influences the prevalence of gestational diabetes (GDM) and its progression to manifest diabetes postpartum, being higher in non-European populations. This may partly be explained by differences in insulin secretion and action. Aims of the present study were to evaluate glucose homeostasis after GDM, the impact of ethnicity and other determinants of glucose toleranceBackground and aims: Ethnicity influences the prevalence of gestationaldiabetes (GDM) and its progression to manifest diabetes postpartum, beinghigher in non-European populations. This may partly be explained by differences in insulin secretion and action. Aims of the present study were toevaluate glucose homeostasis after GDM, the impact of ethnicity and otherdeterminants of glucose tolerance pos
Astrocytes are essential cells for normal brain functionality and have recently emerged as key players in many neurological diseases. However, the limited availability of human primary astrocytes for cell culture studies hinders our understanding of their physiology and precise role in disease development and progression. Here, we describe a detailed step-by-step protocol to rapidly and efficientl
Supercritical n-decane is applied in the regenerative cooling system of scramjet engines while scramjets are always in various irregular movements. With the desire to explore heat transfer performance of supercritical n-decane under actual flight conditions, numerical simulations and analysis of different states during the accelerated flight process are carried out under three different heat fluxe
Well-characterized archival formalin-fixed paraffin-embedded (FFPE) tissues are of much value for prospective biomarker discovery studies, and protocols that offer high throughput and good reproducibility are essential in proteomics. Therefore, we implemented efficient paraffin removal and protein extraction from FFPE tissues followed by an optimized two-enzyme digestion using suspension trapping
At the 100 years anniversary in 2020 of the Reunion around 650 memorials have been protected. The memorials are to be found all over Denmark, where they constitute the largest group. The time of their erection, the localization, design, inscriptions, pictures and initiators are relatively well known. The article investigates two main questions. Firstly, why have so many memorials for the Reunion b
Efficient and robust control strategies can greatly contribute to the reliability of fuel cell systems, and a stable output voltage is a key criterion for evaluating a fuel cell system's reliability as a power source. In this study, a polymer electrolyte fuel cell (PEFC) system model is developed, and its performances under different operating conditions are studied. Then two different novel contr
Background: This study investigates the patterns of PET-positive lymph nodes (LNs) in anal cancer. The aim was to provide information that could inform future anal cancer radiotherapy contouring guidelines. Methods: The baseline [18F]-FDG PET-CTs of 190 consecutive anal cancer patients were retrospectively assessed. LNs with a Deauville score (DS) of ≥3 were defined as PET-positive. Each PET-posit
Risk factors for ischemic stroke is suggested to differ by etiologic subtypes. The purpose of this study was to examine the associations between modifiable and non-modifiable risk factors and atherothrombotic stroke (i.e., excluding cardioembolic stroke), and to examine if the potential benefit of modifiable lifestyle factors differs among subjects with and without predisposing comorbidities. Afte
Patient associations for cancer patients (PACPs) are increasing in number as well as in the number of members. We utilised a questionnaire to investigate how members of 13 PACPs motivated their memberships. The study included 1,810 individuals who had been treated for breast cancer, gynaecological cancer, or prostate cancer. Through questionnaires these individuals were asked to articulate why the
Abstract. Wigren M, Kolbus D, Dunér P, Ljungcrantz I, Söderberg I, Björkbacka H, Fredrikson GN, Nilsson J. (Malmö University Hospital, Lund University; Malmö University, Malmo; Sweden) Evidence for a role of regulatory T cells in mediating the atheroprotective effect of apolipoprotein B peptide vaccine. J Intern Med 2010; doi: 10.1111/j.13 65-2796.2010.02311.x. Objectives. Autoimmune responses aga
Aim: This study evaluates if accelerometer measured physical activity is related to higher composite risk factor scores for cardiovascular disease (CVD) in children. Methods: Cross-sectional study that included 223 children aged 7.9-11.1 years (boys n=123, girls n=100). Daily physical activity was assessed by accelerometers for four days. Body fat was quantified by dual x-ray absorptiometry. Maxim
Little is known concerning the amount of time doctors spend doing different work tasks. A comparative study between four surgical departments in Sweden and England was performed. The time study shows that doctors in Sweden spent around 37% of working hours on administration and 40% on patient work. The numbers in England were 15% and 66% respectively. From the survey, only performed in Sweden, it
