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Gene therapy approaches using viral vectors for the overexpression of target genes have been for several years the focus of gene therapy research against neurological disorders. These approaches deliver robust expression of therapeutic genes, but are typically limited to the delivery of single genes and often do not manipulate the expression of the endogenous locus. In the last years, the advent o
Large drop towers let you experience a couple of seconds of nearly free fall before stopping gracefully in magnetic brakes or bouncing a number of times on compressed air, as in the Turbo Drop tower considered in this work, where many complementary representations are used. An accelerometer taken along on the ride captured the forces experienced by the body, and a pressure sensor provided a simult
Pandemics such as Covid-19 have posed a set of questions concerning safe space usage given the risk of virus transmission in confined and open spaces. In this context, this report presents a risk analysis methodology for the use of crowd modelling tools as an aid to assess safety in confined and open spaces. Crowd models can be used to investigate people movement in the built environment, thus the
Background: Diastasis of the rectus abdominis muscle is a common condition. There are no generally accepted criteria for diagnosis or treatment of diastasis of the rectus abdominis muscle, which causes uncertainty for the patient and healthcare providers alike. Methods: The consensus document was created by a group of Swedish surgeons and based on a structured literature review and practical exper
Magnetic resonance spectroscopy (MRS) is a non-invasive technique that can be used to detect and quantify multiple metabolites. This chapter will review some of the applications of MRS to the study of brain functions. Typically, (1)H-MRS can detect metabolites reflecting neuronal density and integrity, markers of energy metabolism or inflammation, as well as neurotransmitters. The complexity of th
For developing countries like Pakistan, in the absence and scarcity of trust-worthy solar radiation data, the need for an empirical model to predict global solar radiation seems inevitable. Various climatological parameters can be used to develop such models. In this study, linear regression models are developed to estimate the monthly average daily global radiation using cloudiness data for Karac
A delay in surgery due to laboratory abnormalities may increase mortality in patients with hip fracture. In order to optimize the logistics for urgent surgery in patients with hip fractures and anti-vitamin K treatment, individualized doses of a Prothrombin Concentrate were guided by a bedside whole blood prothrombin time test. Thirty patients with emergency hip fracture and preoperative anti-vit
PURPOSE: This study aimed to determine if there are any associations between serum levels of inflammatory markers and proliferative retinopathy (PDR) in type 1 diabetic patients. DESIGN: A cross-sectional design was utilized for this study. METHODS: One hundred twenty-eight type 1 diabetic patients underwent stereo fundus photography according to the Early Treatment Diabetic Retinopathy Study and
Abstract in Russian В данной работе был использован фантом Алдерсон-РАНДО для экспериментального определения коэффициентов перехода для условий внешнего облучения. Были смоделированы следующие конфигурации облучения: ротационная геометрия облучения с использованием различных точечных источников (99mTc, 131I + 133Ba, 137Cs, 60Co); передне-задняя и задне-передняя геометрия облучения источником 137CsIn the present paper the Alderson RANDO phantom have been used to experimentally determine conversion coefficients. A limited number of exposure situations were investigated for this purpose: rotational-geometry with different radiation point sources (99mTc, 131I+133Ba, 137Cs, 60Co), AP- and PA-geometry with 137Cs and a special pocket-geometry with 137Cs. All experiments were carried out on a larg
The Lake Poopo basin, located on the Bolivian Altiplano, is extremely vulnerable to environmental degradation. The basin displays extreme spatial and temporal variations of water resources and rapidly decreasing water quality due to anthropogenic and natural pollution. The region’s population lives in extreme poverty, and the authorities’ efforts to manage the water resources efficiently have been
Summary: Polymethylmethacrylate, as a widely used material for vertebroplasty, has several drawbacks such as heat development and high allergenic potential. In order to avoid these drawbacks ceramic cement materials have been developed. The purpose of this study was to evaluate a new biointegrative material for vertebroplasty in osteoporotic vertebral fractures regarding pain relief, safety aspect
A modified Delphi method was used to determine thresholds for Minimum Data Set quality indicators for Icelandic nursing homes. The thresholds were then applied to quality outcomes in Icelandic nursing homes for the year 2009. The thresholds indicate areas of good or poor care and can be used for planning services. Icelandic nursing homes seem to be doing best in incontinence and nutritional care.
It is well known that user proximity introduces absorption and impedance mismatch losses that severely degrade multiple-input multiple-output (MIMO) performance of handset antennas. In this work, we experimentally verified the potential of adaptive impedance matching (AIM) to mitigate user interaction effects and identified the main AIM gain mechanism in realistic systems. A practical setup includ
Consider a reflected random walk Wn+1 = (W-n +X-n)(+), where X-o, X-1,... are i.i.d. with negative mean and subexponential with common distribution F. It is shown that the probability that the maximum within a regenerative cycle with mean mu exceeds x is approximately mu (F) over bar(x) as x --> infinity, and thereby that max (W-o,..., W-n) has the same asymptotics as max(X-o,...,X-n) as n --> inf
Soft-input/soft-output symbol decoding plays a significant role in iterative decoding. We propose a simple optimal soft-input/soft-output symbol decoding algorithm for linear block codes which requires one forward recursion using a trellis. For many codes the decoding complexity is lower than previous methods, such as the algorithm by Bahl et al. (1974), and the decrease is shown at its most when
