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The recent development of several tau positron emission tomography (PET) tracers represents a major milestone for the Alzheimer's disease (AD) field. These tau PET tracers bind tau neurofibrillary tangles, a key neuropathological characteristic of AD that is tightly linked to synaptic loss, brain atrophy, and cognitive decline. It is notable that these tau PET tracers show low uptake in most non-A
The study of a turbulent premixed flame often involves analysing quantities conditioned to different iso-surfaces of a reactive scalar field. Under the influence of turbulence, such a surface is deformed and translated. To track the surface motion, the displacement speed of the scalar field respective to the local flow velocity is widely used and this quantity is currently receiving growing attent
(KxNa1-x)NbO3 (KNN) and its solid solutions are considered as potential alternatives to traditional Pb-based piezoelectric materials. Recent investigations indicated that the local structure in KNN is much more complex than its long-range average structure. Here, we have undertaken a systematic investigation of the temperature-dependent evolution of local and average structures of KNN5 [(KxNa1-x)N
Purpose: Although tumor infiltrating lymphocytes (TIL) assessment has been acknowledged to have both prognostic and predictive importance in triple negative breast cancer (TNBC), it is subject to inter and intra-observer variability that has prevented widespread adoption. Here we constructed a machine-learning based breast cancer TIL scoring approach and validated its prognostic potential in multi
Objective To compare the performance of the bias-adjusted meta-analysis to the conventional meta-analysis assessing seasonal influenza vaccine effectiveness among community-dwelling elderly aged 60 years and older. Study Design and Setting Systematic literature search revealed 14 cohort studies that met inclusion and exclusion criteria. Laboratory-confirmed influenza, influenza-like illness, hos
At present, the prevalence of electric vehicles is increasing continuously. In particular, there are promising applications for commercial vehicles transfering from conventional to full electric, due to lower operating costs and stricter emission regulations. Thus, cost analysis from the fleet perspective becomes important. The study of cost competitiveness of different drivetrain designs is neces
Over the past couple of decades, increased interdependencies between and institutional defragmentation of, our Critical Infrastructures (CIs) have created a setting were traditional risk management might no longer suffice. In particular, analysis and management of risks have evolved from being a predominantly intra-organisational task towards a process that also requires inter-organisational coord
Background: The incidence of invasive cutaneous melanoma (CM) is increasing in Sweden. The aim was to present age-and sex-specific trends of the age-standardised incidence and the average annual percentage change (AAPC) for in situ and invasive CM. Methods: Joinpoint regression models were used to analyse data from the Swedish Cancer Register and the Swedish Melanoma Registry 1997–2018 (N = 35,350
The focus of this study was the empirical modelling of the high-speed bearings life and failure modes of a through-flow universal motor. An approach was used facilitating predictions of the life through-range of various conditions. The model estimates bearing life for the survival probability of 50% – L50. It influences parameters such as bearing temperature, speed factor, equivalent load, grease
Purpose: Monte Carlo (MC) modelling techniques can assess the quantitative accuracy of both planar and SPECT Nuclear Medicine images. It is essential to validate the MC code's capabilities in modelling a specific clinical gamma camera, for radionuclides of interest, before its use as a clinical image simulator. This study aimed to determine if the SIMIND MC code accurately simulates emission image
Our aesthetic response to the Universe, and the complexity of concepts through which we understand it, are inherently bound together in how we meaningfully interpret its nature. Over millennia the abstracted and intangible concepts of science have been developed and communicated through a rich array of representations across a variety of modes. The interpretation of such representations is a compl
We present a dual-wavelength polarimetric measurement method to distinguish species and sexes of disease transmitting mosquitoes in flight. By measuring co- and de-polarized backscattered light at 808 and 1550nm, the degree of linear polarization, wingbeat frequency, reflectance, spectral ratio and glossiness of mosquitoes can be retrieved. Body and wing contributions to these signals can be separ
Objective: To identify circulating angiogenic and inflammatory biomarkers with potential in screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc), and in early diagnosis and determination of treatment response in PAH. Method: Plasma samples were taken at the time of PAH diagnosis and at treatment follow-up after a median (interquartile range) of 4 months (3–9.8 months) in
Conodonts have been a key tool for biostratigraphical, evolutionary and palaeobiogeographical studies, and the GermanicBasin has been one of the most important regions for these studies. However, few modern studies provide systematic data onthe mainly endemic conodonts of the Middle Triassic Germanic Basin. Here we document conodonts from two sections inGermany, one Bithynian in age and the other
The cause of the Triassic-Jurassic (Tr-J) boundary biotic crisis, one of the ‘Big Five’ mass extinctions of the Phanerozoic, remains controversial. In this study, we analyzed multiple sulfur-isotope compositions (δ33S, δ34S and δ36S) of pyrite and Spy/TOC ratios in two Tr-J successions (Mariental, Mingolsheim) from the European Epicontinental Seaway (EES) in order to better document ocean-redox va
3D-macroporous chitosan-based scaffolds (cryogels) were produced via growth of metal-polymer coordinated complexes and electrostatic interactions between oppositely charged groups of chitosan and metal ions under subzero temperatures. A mechanism of reduction of noble metal complexes inside the cryogel walls by glutaraldehyde is proposed, which produces discrete and dispersed noble metal nanoparti
A supervisory observer is a multiple-model architecture, which estimates the parameters and the states of nonlinear systems. It consists of a bank of state observers, where each observer is designed for some nominal parameter values sampled in a known parameter set. A selection criterion is used to select a single observer at each time instant, which provides its state estimate and parameter value
Novel Sm2O3−NiO composite was prepared as the functional electrolyte for the first time. The total electrical conductivity of Sm2O3−NiO is 0.38 S cm−1 in H2/air condition at 550 °C. High performance, e.g. 718 mW cm−2, was achieved using Sm2O3−NiO composite as an electrolyte of solid oxide fuel cells operated at 550 °C. The electrical properties and electrochemical performance are strongly depended
Background: As a renewable energy solution, photovoltaics (PVs) are crucial in the transition to a more sustainable energy system. Besides large PV installations, household adoption of PVs will be an important contribution to this transition. However, the adoption of PVs on a household level faces many barriers, with gathering and understanding information being one of the major barriers. The aim
