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Voorhees et al. (Reports, 5 November 2010, p. 835) determined the structure of elongation factor Tu (EF-Tu) and aminoacyl-transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog. However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely
This review article focuses on advances and technical developments of the realm of membrane extraction techniques for the analytes that are (made) amenable to gas chromatographic analysis, and sheds light on the analytical applications to biological and environmental samples. In this review, the state of the art in this growing area of membrane extraction for gas chromatography is presented and se
Objective:To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies. Methods:In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 with clinical dementia with Lewy bodies (DLB), 181 with multiple system atrophy (M
We present a new high delay resolution method to detect ultra-wideband (UWB) scatterers when using frequency domain measurements. Our approach makes use of the impulse response envelope amplitudes and delays measured over a distance that is larger than the region of stationarity, and detects the 2D coordinates of the channel scatterers, assuming that only single-scattering (single-interaction) pro
The paper reports a study involving the use of Halomonas boliviensis, a moderate halophile, for co-production of compatible solute ectoine and biopolyester poly(3-hydroxybutyrate) (PHB) in a process comprising two fed-batch cultures. Initial investigations on the growth of the organism in a medium with varying NaCl concentrations showed the highest level of intracellular accumulation of ectoine (0
OBJECTIVE - Insulinoma-associated protein 2 (IA-2) is a major autoantigen in type I diabetes, and IA-2 autoantibodies are routinely detected by a liquid-phase radioimmunoprecipitation assay. The present experiments were initiated to develop a new assay that does not require the use of radioisotopes or autoantigens prepared in bacteria or by in vitro transcription/translation. RESEARCH DESIGN AND M
BACKGROUND: : Atherosclerosis is considered to be an inflammatory disease. Infections are a significant cause of inflammation. Acute infections might precipitate acute coronary syndromes (ACS) whereas chronic infections might be stimuli for the development of atherosclerosis. METHODS: : Coronary angiograms were done on 211 of 335 patients with ACS and the percentage of coronary obstruction was det
Denna studie har syftat till att undersöka effekten av ökat socialt ansvar bland realityprogram på tittarnas attityder. För att undersöka syftet har vi genomfört en fallstudie som studerar realityprogrammet Paradise Hotel. Programmet har antagit ett mer socialt ansvarsfullt koncept i deras nya format Paradise. I studien har semistrukturerade intervjuer genomförts för att undersöka hur tittarnas atThis study has aimed to examine the impact of increased social responsibility among reality shows on viewer attitudes. In order to investigate the aim we have conducted a case study examining the reality show Paradise Hotel. The program has adopted a more socially responsible concept in its new format called Paradise. Semi-structured interviews have been conducted in order to explore how viewers’
The purpose of this paper is to analyse the phenomenon of country branch’s communication alignment between the corporate and country-specifics, based on the example of the German development organisation GIZ and its country branch GIZ Pakistan. This includes how the communication strategy and concepts are aligned and how the alignment is negotiated and decided. The analysis is guided by the interp
An investigation into the use of statistical texture analysis in combination with ultra high-frequency ultrasound for diagnosing Hirschsprung’s disease (HD); An illness that manifests itself through the absence of ganglia cells in lower parts of the intestine. Current diagnostic techniques carry a higher risk of long-term consequences in newborns and children which enables a new avenue of research
Elförsörjningen som till huvuddel kommer från fossila bränslen uppfyller vanligen inte efterfrågan i Irak. Samtidigt som det finns goda förutsättningar och stor potential för att installera och utnyttja solel som en lösning för den bristande elförsörjningen men med omtanke som värnar om miljön. Idag har cirka 20 procent av den irakiska befolkningen ingen tillgång till el, de återstående 80 procentThe main supply of electricity from fossil fuels does not usually meet demand in Iraq. At the same time, there are good conditions and great potential for installing and utilizing environmental friendly electricity from solar energy as a solution to the lack of power supply. Today, about 20 percent of the Iraqi population has no access to electricity, the remaining 80 percent have no continuous el
In this thesis the WKB-approximation is used to simulate the tunneling current for an Esaki nanowire diode and the result is compared to data from Esaki nanowire diodes grown with MOVPE. The WKB-approximation with triangular potential barrier predicts a strong increase of the tunneling current as a function of the doping densities and at the highest doping levels it gives lower tunneling distances
This thesis examines a local low-carbon energy transition in an urban context with regard to energy justice. It takes the Vauban district in Freiburg (Germany) as a case study which has been described as a successful case of energy transition and a model for sustainable urban development. From a theoretical point of view, energy justice encompasses a fair distribution of costs and benefits of an e
Tidigare studier indikerar att ooider har förutsättningar att användas som naturliga arkiv för att undersöka variationer i oceankemin samt klimatförändringar som sträcker sig hundratals år tillbaks. Ooider är sfäriska eller ellipsoidformade karbonatkorn med en medelstorlek mellan 0.25 och 2 millimeter. Ooidens struktur kan variera, men gemensamt för dem är att de utgörs av en kärna som kan vara en
Det finns åtta dämmen och tre aktiva vattenkraftverk i Kävlingeån, som är ett av Skånes största samt fiskrikaste vattendrag. Då dämmena segmenterar ån skapar detta miljöproblem; organismer förhindras migration för bland annat fortplantning och födosök. Arter såsom öring och den akut hotade ålen lever i Kävlingeån och är beroende av framkomliga vandringsvägar samt lekplatser. Syftet med denna studi
Det finns åtta dämmen och tre aktiva vattenkraftverk i Kävlingeån, som är ett av Skånes största samt fiskrikaste vattendrag. Då dämmena segmenterar ån skapar detta miljöproblem; organismer förhindras migration för bland annat fortplantning och födosök. Arter såsom öring och den akut hotade ålen lever i Kävlingeån och är beroende av framkomliga vandringsvägar samt lekplatser. Syftet med denna studi
The observed and expected changes in the environment due to human actions implies risks that future food production will be insufficient. Pre- dicting the impact these changes have on the agricultural system could be beneficial by allowing for proactive mitigating efforts. The prediction of these impacts often involve large computer programs that simulate the behavior of the environment. By implem
Accurate quantitative protein analysis is crucial to identify proteins that are differentially abundant between samples, to provide clues about disease mechanisms or act as biomarkers. However, in most workflows, proteins are digested to peptides, and the resulting peptides are quantified as proxies for proteins. No consensus method for going from peptide to protein level quantification exist, and
Syftet med denna uppsats är att se huruvida de svenska bestämmelserna rörande lagöverträdare under 15 år stämmer överens med Europakonventionen och Barnkonventionen. Konventionerna är ratificerade och Sverige är således förpliktade att följa dess bestämmelser. Europakonventionen har en starkare ställning än Barnkonventionen eftersom den är del av svensk lag. Europakonventionen innehåller, till skiThe purpose of this essay is to compare the Swedish regulation regarding offenders under the legal age of criminal responsibility, with the European Convention on Human Rights, ECHR, and the United Nations Convention on the Rights of the Child, UNCRC. Sweden has ratified the conventions which makes Sweden obliged to follow their regulations. The ECHR is part of Swedish legislation, but the UNCRC i
